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Automating structured clinical interviews could revolutionize mental healthcare accessibility, yet existing large language models (LLMs) approaches fail to align with psychiatric diagnostic protocols. We present MAGI, the first framework…

Computation and Language · Computer Science 2025-04-28 Guanqun Bi , Zhuang Chen , Zhoufu Liu , Hongkai Wang , Xiyao Xiao , Yuqiang Xie , Wen Zhang , Yongkang Huang , Yuxuan Chen , Libiao Peng , Yi Feng , Minlie Huang

In this study, we propose a novel human-like memory architecture designed for enhancing the cognitive abilities of large language model based dialogue agents. Our proposed architecture enables agents to autonomously recall memories…

Human-Computer Interaction · Computer Science 2024-04-02 Yuki Hou , Haruki Tamoto , Homei Miyashita

This paper proposes a new depression detection system based on LLMs that is both interpretable and interactive. It not only provides a diagnosis, but also diagnostic evidence and personalized recommendations based on natural language…

Computation and Language · Computer Science 2023-05-10 Wei Qin , Zetong Chen , Lei Wang , Yunshi Lan , Weijieying Ren , Richang Hong

LLM-based agents have emerged as transformative tools capable of executing complex tasks through iterative planning and action, achieving significant advancements in understanding and addressing user needs. Yet, their effectiveness remains…

Human-Computer Interaction · Computer Science 2025-08-26 Mithat Can Ozgun , Jiahuan Pei , Koen Hindriks , Lucia Donatelli , Qingzhi Liu , Junxiao Wang

This study investigates clinicians' perceptions and attitudes toward an assistive artificial intelligence (AI) system that employs a speech-based explainable ML algorithm for detecting depression. The AI system detects depression from…

Human-Computer Interaction · Computer Science 2024-10-25 Kexin Feng , Theodora Chaspari

At the heart of medicine lies the physician-patient dialogue, where skillful history-taking paves the way for accurate diagnosis, effective management, and enduring trust. Artificial Intelligence (AI) systems capable of diagnostic dialogue…

Recent advances in large language models (LLMs) have accelerated the development of conversational agents capable of generating human-like responses. Since psychiatric assessments typically involve complex conversational interactions…

Computation and Language · Computer Science 2025-01-06 Jingoo Lee , Kyungho Lim , Young-Chul Jung , Byung-Hoon Kim

Objective: This paper introduces a patient simulator for scalable, automated evaluation of healthcare conversational agents, generating realistic, controllable interactions that systematically vary across medical, linguistic, and behavioral…

Modeling latent clinical constructs from unconstrained clinical interactions is a unique challenge in affective computing. We present ADAPTS (Agentic Decomposition for Automated Protocol-agnostic Tracking of Symptoms), a framework for…

Artificial Intelligence · Computer Science 2026-05-07 Alexandria K. Vail , Marcelo Cicconet , Katie Aafjes-van Doorn , Ryan Maroney , Marc Aafjes

Depression is a widespread mental disorder that affects millions worldwide. While automated depression assessment shows promise, most studies rely on limited or non-clinically validated data, and often prioritize complex model design over…

Computation and Language · Computer Science 2025-08-07 Zhuang Chen , Guanqun Bi , Wen Zhang , Jiawei Hu , Aoyun Wang , Xiyao Xiao , Kun Feng , Minlie Huang

Effective dementia caregiving requires training and adaptive communication, but assistive AI and robotics are constrained by a lack of context-rich, privacy-sensitive data on how people living with Alzheimer's disease and related dementias…

Human-Computer Interaction · Computer Science 2026-04-01 Kruthika Gangaraju , Shu-Fen Wung , Kevin Berner , Jing Wang , Fengpei Yuan

Psychological counseling faces huge challenges due to the growing demand for mental health services and the shortage of trained professionals. Large language models (LLMs) have shown potential to assist psychological counseling, especially…

Artificial Intelligence · Computer Science 2025-07-28 Yigui Feng , Qinglin Wang , Ke Liu , Xinhai Chen , Bo Yang , Jie Liu

Young people's mental well-being is a global concern, with peer support playing a key role in daily emotional regulation. Conversational agents are increasingly viewed as promising tools for delivering accessible, personalised peer support,…

Human-Computer Interaction · Computer Science 2025-12-01 Ruoyu Wen , Xiaoli Wu , Kunal Gupta , Simon Hoermann , Mark Billinghurst , Alaeddin Nassani , Dwain Allan , Thammathip Piumsomboon

Open-domain dialogue systems have seen remarkable advancements with the development of large language models (LLMs). Nonetheless, most existing dialogue systems predominantly focus on brief single-session interactions, neglecting the…

Computation and Language · Computer Science 2025-02-14 Hao Li , Chenghao Yang , An Zhang , Yang Deng , Xiang Wang , Tat-Seng Chua

Advances in large language models (LLMs) have enabled a wide range of applications. However, depression prediction is hindered by the lack of large-scale, high-quality, and rigorously annotated datasets. This study introduces DepressLLM,…

Computation and Language · Computer Science 2025-08-13 Sehwan Moon , Aram Lee , Jeong Eun Kim , Hee-Ju Kang , Il-Seon Shin , Sung-Wan Kim , Jae-Min Kim , Min Jhon , Ju-Wan Kim

Mental health challenges are rising globally, while traditional support services face limited availability and high costs. Large language models offer potential for conversational support, but often lack personalization, empathy, and…

Human-Computer Interaction · Computer Science 2026-04-24 Truong Le Minh Toan , Dieu Bang Mach , Tan Duy Le , Nguyen Tan Viet Tuyen

The development of large language models (LLMs) has brought unprecedented possibilities for artificial intelligence (AI) based medical diagnosis. However, the application perspective of LLMs in real diagnostic scenarios is still unclear…

Computation and Language · Computer Science 2024-05-21 Zhoujian Sun , Cheng Luo , Ziyi Liu , Zhengxing Huang

Rare disease diagnosis is inherently challenging due to heterogeneous symptoms, limited clinical familiarity, and fragmented evidence across specialties. Recent large language model (LLM)-based agentic systems have shown promise by…

Human-Computer Interaction · Computer Science 2026-03-31 Peng Kuai , Yukun Yang , Shaolun Ruan , Junchi Xu , Yanjie Zhang , Lin Zhang , Min Zhu , Rui Sheng

The clinical diagnosis of most mental disorders primarily relies on the conversations between psychiatrist and patient. The creation of such diagnostic conversation datasets is promising to boost the AI mental healthcare community. However,…

Computation and Language · Computer Science 2024-12-30 Congchi Yin , Feng Li , Shu Zhang , Zike Wang , Jun Shao , Piji Li , Jianhua Chen , Xun Jiang

Simulating dementia patients with large language models (LLMs) is challenging due to the need to jointly model cognitive impairment, emotional dynamics, and nonverbal behaviors over long conversations. We present DemMA, an expert-guided…

Multiagent Systems · Computer Science 2026-01-13 Yutong Song , Jiang Wu , Kazi Sharif , Honghui Xu , Nikil Dutt , Amir Rahmani