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Imitation learning holds tremendous promise in learning policies efficiently for complex decision making problems. Current state-of-the-art algorithms often use inverse reinforcement learning (IRL), where given a set of expert…

Robotics · Computer Science 2023-02-22 Siddhant Haldar , Vaibhav Mathur , Denis Yarats , Lerrel Pinto

Gene regulation is a series of processes that control gene expression and its extent. The connections among genes and their regulatory molecules, usually transcription factors, and a descriptive model of such connections, are known as gene…

Molecular Networks · Quantitative Biology 2017-04-24 Yasser Abduallah , Turki Turki , Kevin Byron , Zongxuan Du , Miguel Cervantes-Cervantes , Jason T. L. Wang

Optimal transport (OT) is a widely used technique in machine learning, graphics, and vision that aligns two distributions or datasets using their relative geometry. In symmetry-rich settings, however, OT alignments based solely on pairwise…

Machine Learning · Computer Science 2025-09-26 Annabel Ma , Kaiying Hou , David Alvarez-Melis , Melanie Weber

Recently, deep learning approaches for accelerated MRI have been extensively studied thanks to their high performance reconstruction in spite of significantly reduced runtime complexity. These neural networks are usually trained in a…

Image and Video Processing · Electrical Eng. & Systems 2020-09-01 Gyutaek Oh , Byeongsu Sim , Hyungjin Chung , Leonard Sunwoo , Jong Chul Ye

Gene Regulatory Network (GRN) plays an important role in knowing insight of cellular life cycle. It gives information about at which different environmental conditions genes of particular interest get over expressed or under expressed.…

Computational Engineering, Finance, and Science · Computer Science 2013-10-10 Chanda Panse , Dr. Manali Kshirsagar

From ecology to atmospheric sciences, many academic disciplines deal with data characterized by intricate spatio-temporal complexities, the modeling of which often requires specialized approaches. Generative models of these data are of…

Machine Learning · Computer Science 2021-10-01 Konstantin Klemmer , Tianlin Xu , Beatrice Acciaio , Daniel B. Neill

We introduce the Approximated Optimal Transport (AOT) technique, a novel training scheme for diffusion-based generative models. Our approach aims to approximate and integrate optimal transport into the training process, significantly…

Computer Vision and Pattern Recognition · Computer Science 2024-03-11 Daegyu Kim , Jooyoung Choi , Chaehun Shin , Uiwon Hwang , Sungroh Yoon

Detecting Out-of-Distribution (OOD) inputs is crucial for improving the reliability of deep neural networks in the real-world deployment. In this paper, inspired by the inherent distribution shift between ID and OOD data, we propose a novel…

Computer Vision and Pattern Recognition · Computer Science 2024-10-11 Ao Ke , Wenlong Chen , Chuanwen Feng , Yukun Cao , Xike Xie , S. Kevin Zhou , Lei Feng

Network modeling is a key enabler to achieve efficient network operation in future self-driving Software-Defined Networks. However, we still lack functional network models able to produce accurate predictions of Key Performance Indicators…

Networking and Internet Architecture · Computer Science 2021-06-15 Krzysztof Rusek , José Suárez-Varela , Paul Almasan , Pere Barlet-Ros , Albert Cabellos-Aparicio

In this work, we develop an optimal transport (OT) based framework to select informative prototypical examples that best represent a given target dataset. Summarizing a given target dataset via representative examples is an important…

Machine Learning · Computer Science 2021-04-06 Karthik S. Gurumoorthy , Pratik Jawanpuria , Bamdev Mishra

Determining gene regulatory network (GRN) structure is a central problem in biology, with a variety of inference methods available for different types of data. For a widely prevalent and challenging use case, namely single-cell gene…

Molecular Networks · Quantitative Biology 2024-10-14 Yue Wang , Peng Zheng , Yu-Chen Cheng , Zikun Wang , Aleksandr Aravkin

Learning representations that capture both intrinsic data geometry and target-relevant structure remains a fundamental challenge, particularly in settings where data reduction must balance compression with predictive fidelity. While…

Machine Learning · Computer Science 2026-05-28 Sai-Aakash Ramesh , Archit Sood , Andrew Corbett , Tim Dodwell

Gene regulatory network (GRN) modeling is a well-established theoretical framework for the study of cell-fate specification during developmental processes. Recently, dynamical models of GRNs have been taken as a basis for formalizing the…

Molecular Networks · Quantitative Biology 2015-10-15 Jose Davila-Velderrain , Luis Juarez-Ramiro , Juan C. Martinez-Garcia , Elena R. Alvarez-Buylla

Predicting genetic perturbations enables the identification of potentially crucial genes prior to wet-lab experiments, significantly improving overall experimental efficiency. Since genes are the foundation of cellular life, building gene…

Quantitative Methods · Quantitative Biology 2025-05-09 Changxi Chi , Jun Xia , Jingbo Zhou , Jiabei Cheng , Chang Yu , Stan Z. Li

During the last decade, incremental sampling-based motion planning algorithms, such as the Rapidly-exploring Random Trees (RRTs) have been shown to work well in practice and to possess theoretical guarantees such as probabilistic…

Robotics · Computer Science 2010-05-05 Sertac Karaman , Emilio Frazzoli

Trajectory data mining is crucial for smart city management. However, collecting large-scale trajectory datasets is challenging due to factors such as commercial conflicts and privacy regulations. Therefore, we urgently need trajectory…

Machine Learning · Computer Science 2025-02-04 Jingyuan Wang , Yujing Lin , Yudong Li

Optimal transport (OT) is a versatile framework for comparing probability measures, with many applications to statistics, machine learning, and applied mathematics. However, OT distances suffer from computational and statistical scalability…

Statistics Theory · Mathematics 2022-06-08 Ziv Goldfeld , Kengo Kato , Gabriel Rioux , Ritwik Sadhu

\textbf{Motivation:} Predicting single-cell perturbation responses requires mapping between two unpaired single-cell data distributions. Optimal transport (OT) theory provides a principled framework for constructing such mappings by…

Machine Learning · Computer Science 2025-04-22 Yanshuo Chen , Zhengmian Hu , Wei Chen , Heng Huang

Advances in optical and electrophysiological recording technologies have made it possible to record the dynamics of thousands of neurons, opening up new possibilities for interpreting and controlling large neural populations in behaving…

Neurons and Cognition · Quantitative Biology 2023-11-20 Fatih Dinc , Adam Shai , Mark Schnitzer , Hidenori Tanaka

Matching a source to a target probability measure is often solved by instantiating a linear optimal transport (OT) problem, parameterized by a ground cost function that quantifies discrepancy between points. When these measures live in the…

Machine Learning · Computer Science 2023-11-27 Othmane Sebbouh , Marco Cuturi , Gabriel Peyré