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Preference learning has garnered extensive attention as an effective technique for aligning diffusion models with human preferences in visual generation. However, existing alignment approaches such as Diffusion-DPO suffer from two…

Machine Learning · Computer Science 2026-05-19 Xiaomeng Yang , Mengping Yang , Junyan Wang , Zhijian Zhou , Zhiyu Tan , Hao Li

The inverse folding problem, aiming to design amino acid sequences that fold into desired three-dimensional structures, is pivotal for various biotechnological applications. Here, we introduce a novel approach leveraging Direct Preference…

Machine Learning · Computer Science 2025-06-04 Junde Xu , Zijun Gao , Xinyi Zhou , Jie Hu , Xingyi Cheng , Le Song , Guangyong Chen , Pheng-Ann Heng , Jiezhong Qiu

In the domain of complex reasoning tasks, such as mathematical reasoning, recent advancements have proposed the use of Direct Preference Optimization (DPO) to suppress output of dispreferred responses, thereby enhancing the long-chain…

Computation and Language · Computer Science 2025-10-27 Weibin Liao , Xu Chu , Yasha Wang

Direct alignment methods typically train large language models (LLMs) by contrasting the likelihoods of preferred and dispreferred responses. While effective at capturing relative preferences, these methods are widely observed to suppress…

Computation and Language · Computer Science 2025-12-04 Kaiyang Guo , Yinchuan Li , Zhitang Chen

Direct Preference Optimization (DPO) is an effective technique that leverages pairwise preference data (usually one chosen and rejected response pair per user prompt) to align LLMs to human preferences. In practice, multiple responses can…

Computation and Language · Computer Science 2024-11-11 Pulkit Pattnaik , Rishabh Maheshwary , Kelechi Ogueji , Vikas Yadav , Sathwik Tejaswi Madhusudhan

Preference optimization (PO) is indispensable for large language models (LLMs), with methods such as direct preference optimization (DPO) and proximal policy optimization (PPO) achieving great success. A common belief is that DPO is…

Machine Learning · Computer Science 2026-05-18 Yue Wang , Qizhou Wang , Zizhuo Zhang , Gang Niu , Bo Han , Masashi Sugiyama

The practical applications of diffusion models have been limited by the misalignment between generated images and corresponding text prompts. Recent studies have introduced direct preference optimization (DPO) to enhance the alignment of…

Computer Vision and Pattern Recognition · Computer Science 2025-05-29 Zijing Hu , Fengda Zhang , Kun Kuang

In large language model (LLM)-based recommendation systems, direct preference optimization (DPO) effectively aligns recommendations with user preferences, requiring multi-negative objective functions to leverage abundant implicit-feedback…

Information Retrieval · Computer Science 2026-05-04 Xingyu Hu , Kai Zhang , Jiancan Wu , Shuli Wang , Chi Wang , Wenshuai Chen , Yinhua Zhu , Haitao Wang , Xingxing Wang , Xiang Wang

Direct Preference Optimization (DPO) is a widely used reinforcement learning from human feedback (RLHF) method across various domains. Recent research has increasingly focused on the role of token importance in improving DPO effectiveness.…

Computation and Language · Computer Science 2025-12-01 Jian Li , Shenglin Yin , Yujia Zhang , Alan Zhao , Xi Chen , Xiaohui Zhou , Pengfei Xu

Direct Preference Optimization (DPO) has emerged as a simple and effective approach for aligning large language models (LLMs) with human preferences, bypassing the need for a learned reward model. Despite its growing adoption, a fundamental…

Machine Learning · Computer Science 2025-11-10 Yu Pan , Zhongze Cai , Guanting Chen , Huaiyang Zhong , Chonghuan Wang

Our goal is to enable large language models (LLMs) to balance multiple human preference dimensions; such as helpfulness, safety, and verbosity, through principled and controllable alignment. Existing preference optimization methods,…

Machine Learning · Computer Science 2026-02-03 Mete Erdogan

Direct Preference Optimization (DPO) has recently emerged as a simple and effective alternative to reinforcement learning from human feedback (RLHF) for aligning large language models (LLMs) with user preferences. However, existing DPO…

Machine Learning · Computer Science 2025-10-10 Jason Bohne , Pawel Polak , David Rosenberg , Brian Bloniarz , Gary Kazantsev

Preference learning is a key technology for aligning language models with human values. Reinforcement Learning from Human Feedback (RLHF) is a model-based algorithm to optimize preference learning, which first fits a reward model for…

Machine Learning · Computer Science 2024-03-26 Zaifan Jiang , Xing Huang , Chao Wei

In the classical Reinforcement Learning from Human Feedback (RLHF) framework, Proximal Policy Optimization (PPO) is employed to learn from sparse, sentence-level rewards -- a challenging scenario in traditional deep reinforcement learning.…

Machine Learning · Computer Science 2025-05-22 Han Zhong , Zikang Shan , Guhao Feng , Wei Xiong , Xinle Cheng , Li Zhao , Di He , Jiang Bian , Liwei Wang

Diffusion models have achieved promising results for Structure-Based Drug Design (SBDD). Nevertheless, high-quality protein subpocket and ligand data are relatively scarce, which hinders the models' generation capabilities. Recently, Direct…

Biomolecules · Quantitative Biology 2026-02-11 Xiwei Cheng , Xiangxin Zhou , Yuwei Yang , Yu Bao , Quanquan Gu

Direct preference optimization (DPO) is widely used as a simple and stable method for aligning large language models (LLMs) with human preferences. This paper investigates a generalized DPO loss that enables a policy model to match the…

Machine Learning · Computer Science 2025-10-28 Yeongmin Kim , Heesun Bae , Byeonghu Na , Il-Chul Moon

Preference alignment is pivotal for empowering large language models (LLMs) to generate helpful and harmless responses. However, the performance of preference alignment is highly sensitive to the prevalent noise in the preference data.…

Machine Learning · Computer Science 2024-05-29 Xize Liang , Chao Chen , Shuang Qiu , Jie Wang , Yue Wu , Zhihang Fu , Zhihao Shi , Feng Wu , Jieping Ye

Offline preference optimization offers a simpler and more stable alternative to RLHF for aligning language models. However, their effectiveness is critically dependent on ranking accuracy, a metric where further gains are highly impactful.…

Computation and Language · Computer Science 2025-11-18 Ruibo Deng , Duanyu Feng , Wenqiang Lei

The increasing capabilities of large language models (LLMs) raise opportunities for artificial general intelligence but concurrently amplify safety concerns, such as potential misuse of AI systems, necessitating effective AI alignment.…

Machine Learning · Computer Science 2023-09-29 Chaoqi Wang , Yibo Jiang , Chenghao Yang , Han Liu , Yuxin Chen

Direct Preference Optimization (DPO) has shown promising results in aligning generative outputs with human preferences by distinguishing between chosen and rejected samples. However, a critical limitation of DPO is likelihood displacement,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Ruojun Xu , Yu Kai , Xuhua Ren , Jiaxiang Cheng , Bing Ma , Tianxiang Zheng , Qinhlin Lu
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