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Breast cancer is the most common malignancy affecting women worldwide and is notable for its morphologic and biologic diversity, with varying risks of recurrence following treatment. The Oncotype DX Breast Recurrence Score test is an…

Clinical trials are vital for evaluation of safety and efficacy of new treatments. However, clinical trials are resource-intensive, time-consuming and expensive to conduct, where errors in trial design, reduced efficacy, and safety events…

Artificial Intelligence · Computer Science 2025-05-19 Trisha Das , Afrah Shafquat , Beigi Mandis , Jacob Aptekar , Jimeng Sun

The diagnosis of primary liver cancers (PLCs) can be challenging, especially on biopsies and for combined hepatocellular-cholangiocarcinoma (cHCC-CCA). We automatically classified PLCs on routine-stained biopsies using a weakly supervised…

Cervical Cancer is one of the most common forms of cancer in women worldwide. Most cases of cervical cancer can be prevented through screening programs aimed at detecting precancerous lesions. During Digital Colposcopy, Specular Reflections…

Computer Vision and Pattern Recognition · Computer Science 2016-11-17 Abhishek Das , Avijit Kar , Debasis Bhattacharyya

Cervical cancer is the second most common cancer type in women around the world. In some countries, due to non-existent or inadequate screening, it is often detected at late stages, making standard treatment options often absent or…

Like most global cancer registries, the National Cancer Registry in South Africa employs expert human coders to label pathology reports using appropriate International Classification of Disease for Oncology (ICD-O) codes spanning 42…

Machine Learning · Computer Science 2020-08-31 Waheeda Saib , David Sengeh , Gcininwe Dlamini , Elvira Singh

This work shows promising results using multiple instance learning on salivary gland tumours in classifying cancers on whole slide images. Utilising CTransPath as a patch-level feature extractor and CLAM as a feature aggregator, an F1 score…

Image and Video Processing · Electrical Eng. & Systems 2024-08-23 John Charlton , Ibrahim Alsanie , Syed Ali Khurram

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers all over the world. It starts as a polyp in the inner lining of the colon. To prevent CRC, early polyp detection is required. Colonosopy is used for the inspection of the…

Computer Vision and Pattern Recognition · Computer Science 2025-01-17 Alok Ranjan Sahoo , Satya Sangram Sahoo , Pavan Chakraborty

Detecting early-stage ovarian cancer accurately and efficiently is crucial for timely treatment. Various methods for early diagnosis have been explored, including a focus on features derived from protein mass spectra, but these tend to…

Applications · Statistics 2024-01-30 Raymond J. Hinton , Jihyun Byun , Dixon Vimalajeewa , Brani Vidakovic

Nucleus detection in histopathology whole slide images (WSIs) is crucial for a broad spectrum of clinical applications. The gigapixel size of WSIs necessitates the use of sliding window methodology for nucleus detection. However, mainstream…

Image and Video Processing · Electrical Eng. & Systems 2026-02-10 Zhongyi Shui , Honglin Li , Yunlong Zhang , Yuxuan Sun , Yiwen Ye , Pingyi Chen , Ruizhe Guo , Lei Cui , Chenglu Zhu , Lin Yang

Pathologists routinely alternate between different magnifications when examining Whole-Slide Images, allowing them to evaluate both broad tissue morphology and intricate cellular details to form comprehensive diagnoses. However, existing…

Screening mammography is an important front-line tool for the early detection of breast cancer, and some 39 million exams are conducted each year in the United States alone. Here, we describe a multi-scale convolutional neural network (CNN)…

Computer Vision and Pattern Recognition · Computer Science 2017-07-24 William Lotter , Greg Sorensen , David Cox

Cervical cancer is a public health problem, where the treatment has a better chance of success if detected early. The analysis is a manual process which is subject to a human error, so this paper provides a way to analyze argyrophilic…

Histopathology imaging is crucial for the diagnosis and treatment of skin diseases. For this reason, computer-assisted approaches have gained popularity and shown promising results in tasks such as segmentation and classification of skin…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Luis Carlos Rivera Monroy , Leonhard Rist , Martin Eberhardt , Christian Ostalecki , Andreas Baur , Julio Vera , Katharina Breininger , Andreas Maier

In the cancer diagnosis pipeline, digital pathology plays an instrumental role in the identification, staging, and grading of malignant areas on biopsy tissue specimens. High resolution histology images are subject to high variance in…

Image and Video Processing · Electrical Eng. & Systems 2023-08-17 Vasileios Magoulianitis , Catherine A. Alexander , C. -C. Jay Kuo

Squamous cell carcinoma (SCC) is the most common cancer subtype, with an increasing incidence and a significant impact on cancer-related mortality. SCC grading using whole slide images is inherently challenging due to the lack of a reliable…

Tissue typology annotation in Whole Slide histological images is a complex and tedious, yet necessary task for the development of computational pathology models. We propose to address this problem by applying Open Set Recognition techniques…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Adrian Galdran , Katherine J. Hewitt , Narmin L. Ghaffari , Jakob N. Kather , Gustavo Carneiro , Miguel A. González Ballester

Existing deep learning models have achieved promising performance in recognizing skin diseases from dermoscopic images. However, these models can only recognize samples from predefined categories, when they are deployed in the clinic, data…

Computer Vision and Pattern Recognition · Computer Science 2023-09-29 Wei Feng , Lie Ju , Lin Wang , Kaimin Song , Zongyuan Ge

Cell image classification methods are currently being used in numerous applications in cell biology and medicine. Applications include understanding the effects of genes and drugs in screening experiments, understanding the role and…

Quantitative Methods · Quantitative Biology 2022-03-04 Mohammad Shifat-E-Rabbi , Xuwang Yin , Cailey Elizabeth Fitzgerald , Gustavo K. Rohde

Classification of malignancy for breast cancer and other cancer types is usually tackled as an object detection problem: Individual lesions are first localized and then classified with respect to malignancy. However, the drawback of this…

Image and Video Processing · Electrical Eng. & Systems 2020-01-09 Christoph Haarburger , Michael Baumgartner , Daniel Truhn , Mirjam Broeckmann , Hannah Schneider , Simone Schrading , Christiane Kuhl , Dorit Merhof
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