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Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which pathological changes begin many years before the onset of clinical symptoms, making early detection essential for timely intervention. T1-weighted (T1w) Magnetic…
Multimodal MRI provides critical complementary information for accurate brain tumor segmentation. However, conventional methods struggle when certain modalities are missing due to issues such as image quality, protocol inconsistencies,…
Fiber orientation distribution (FOD) is an advanced diffusion MRI modeling technique that represents complex white matter fiber configurations, and a key step for subsequent brain tractography and connectome analysis. Its reliability and…
Brain network analysis is a useful approach to studying human brain disorders because it can distinguish patients from healthy people by detecting abnormal connections. Due to the complementary information from multiple modal neuroimages,…
We develop a general analytical and numerical framework for estimating intra- and extra-neurite water fractions and diffusion coefficients, as well as neurite orientational dispersion, in each imaging voxel. By employing a set of rotational…
Diffusion MRI (dMRI) is the primary imaging modality used to study brain microstructure in vivo. Reliable and computationally efficient parameter inference for common dMRI biophysical models is a challenging inverse problem, due to factors…
Fiber tracking based on diffusion weighted Magnetic Resonance Imaging (dMRI) allows for noninvasive reconstruction of fiber bundles in the human brain. In this chapter, we discuss sources of error and uncertainty in this technique, and…
Multi-modality magnetic resonance imaging (MRI) is essential for the diagnosis and treatment of brain tumors. However, missing modalities are commonly observed due to limitations in scan time, scan corruption, artifacts, motion, and…
Magnetic resonance imaging (MRI) is a powerful and versatile imaging technique, offering a wide spectrum of information about the anatomy by employing different acquisition modalities. However, in the clinical workflow, it is impractical to…
Accurate detection and segmentation of brain tumors from magnetic resonance imaging (MRI) are essential for diagnosis, treatment planning, and clinical monitoring. While convolutional architectures such as U-Net have long been the backbone…
Ill-posed imaging inverse problems remain challenging due to the ambiguity in mapping degraded observations to clean images. Diffusion-based generative priors have recently shown promise, but typically rely on computationally intensive…
This paper presents DFR (Decompose, Fuse and Reconstruct), a novel framework that addresses the fundamental challenge of effectively utilizing multi-modal guidance in few-shot segmentation (FSS). While existing approaches primarily rely on…
Using multimodal Magnetic Resonance Imaging (MRI) is necessary for accurate brain tumor segmentation. The main problem is that not all types of MRIs are always available in clinical exams. Based on the fact that there is a strong…
T2-weighted magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) are essential components for cervical cancer diagnosis. However, combining these channels for training deep learning models are challenging due to…
Vision foundation models like DINOv2 demonstrate remarkable potential in medical imaging despite their origin in natural image domains. However, their design inherently works best for uni-modal image analysis, limiting their effectiveness…
Diffusion-weighted Magnetic Resonance Imaging (dMRI) is increasingly used to study the fetal brain in utero. An important computation enabled by dMRI is streamline tractography, which has unique applications such as tract-specific analysis…
Diffusion MRI (dMRI) provides a distinctive means to probe the microstructural architecture of living tissue, facilitating applications such as brain connectivity analysis, modeling across multiple conditions, and the estimation of…
Fitting multi-exponential models to Diffusion MRI (dMRI) data has always been challenging due to various underlying complexities. In this work, we introduce a novel and robust fitting framework for the standard two-compartment IVIM…
\hspace{2mm} Diffusion-weighted magnetic resonance imaging (dMRI) of the brain offers unique capabilities including noninvasive probing of tissue microstructure and structural connectivity. It is widely used for clinical assessment of…
The complex and dynamic real-world clinical environment demands reliable deep learning (DL) systems. Out-of-distribution (OOD) detection plays a critical role in enhancing the reliability and generalizability of DL models when encountering…