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Imaging mass spectrometry (IMS) has transformed proteomics by providing an avenue for collecting spatially distributed molecular data. Mass spectrometry data acquired with matrix assisted laser desorption ionization (MALDI) IMS consist of…

Applications · Statistics 2016-02-05 Lyron J. Winderbaum , Inge Koch , Ove J. R. Gustafsson , Stephan Meding , Peter Hoffmann

As an important application of spatial databases in pathology imaging analysis, cross-comparing the spatial boundaries of a huge amount of segmented micro-anatomic objects demands extremely data- and compute-intensive operations, requiring…

Databases · Computer Science 2012-08-02 Kaibo Wang , Yin Huai , Rubao Lee , Fusheng Wang , Xiaodong Zhang , Joel H. Saltz

Breadth-first search (BFS) is a fundamental graph algorithm that presents significant challenges for parallel implementation due to irregular memory access patterns, load imbalance and synchronization overhead. In this paper, we introduce a…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-03-04 Marati Bhaskar , Raghavendra Kanakagiri

FPGAs provide a flexible and efficient platform to accelerate rapidly-changing algorithms for computer vision. The majority of existing work focuses on accelerating image classification, while other fundamental vision problems, including…

Image and Video Processing · Electrical Eng. & Systems 2020-03-25 Qijing Huang , Dequan Wang , Yizhao Gao , Yaohui Cai , Zhen Dong , Bichen Wu , Kurt Keutzer , John Wawrzynek

Objective: Acute mountain sickness (AMS) is the most prevalent altitude illness, affecting unacclimatized individuals ascending above 2,500 m and potentially escalating to life threatening cerebral or pulmonary edema. Conventional machine…

Symbolic Computation · Computer Science 2026-05-19 Abu Masum , Mehran Moghadam , M. Hassan Najafi , Bige Unluturk , Ulkuhan Guler , Beth A. Beidleman , Sercan Aygun

Clinical ultrasound acquisition is highly operator-dependent, where rapid probe motion and brightness fluctuations often lead to reconstruction errors that reduce trust and clinical utility. We present UltrasODM, a dual-stream framework…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Mayank Anand , Ujair Alam , Surya Prakash , Priya Shukla , Gora Chand Nandi , Domenec Puig

Molecular similarity search has been widely used in drug discovery to identify structurally similar compounds from large molecular databases rapidly. With the increasing size of chemical libraries, there is growing interest in the efficient…

Hardware Architecture · Computer Science 2021-09-15 Hongwu Peng , Shiyang Chen , Zhepeng Wang , Junhuan Yang , Scott A. Weitze , Tong Geng , Ang Li , Jinbo Bi , Minghu Song , Weiwen Jiang , Hang Liu , Caiwen Ding

Large persistent memories such as NVDIMM have been perceived as a disruptive memory technology, because they can maintain the state of a system even after a power failure and allow the system to recover quickly. However, overheads incurred…

Hardware Architecture · Computer Science 2021-06-29 Jie Zhang , Miryeong Kwon , Donghyun Gouk , Sungjoon Koh , Nam Sung Kim , Mahmut Taylan Kandemir , Myoungsoo Jung

Scientific applications produce vast amounts of data, posing grand challenges in the underlying data management and analytic tasks. Progressive compression is a promising way to address this problem, as it allows for on-demand data…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-05-02 Yanliang Li , Wenbo Li , Qian Gong , Qing Liu , Norbert Podhorszki , Scott Klasky , Xin Liang , Jieyang Chen

Curating, processing, and combining large-scale medical imaging datasets from national studies is a non-trivial task due to the intense computation and data throughput required, variability of acquired data, and associated financial…

Hardware-aware Neural Architecture Search approaches (HW-NAS) automate the design of deep learning architectures, tailored specifically to a given target hardware platform. Yet, these techniques demand substantial computational resources,…

Machine Learning · Computer Science 2024-04-22 Nilotpal Sinha , Peyman Rostami , Abd El Rahman Shabayek , Anis Kacem , Djamila Aouada

The exponential growth of data-intensive machine learning workloads has exposed significant limitations in conventional GPU-accelerated systems, especially when processing datasets exceeding GPU DRAM capacity. We propose MQMS, an augmented…

Hardware Architecture · Computer Science 2024-12-10 Ayush Gundawar , Euijun Chung , Hyesoon Kim

Optical neural networks (ONNs), or optical neuromorphic hardware accelerators, have the potential to dramatically enhance the computing power and energy efficiency of mainstream electronic processors, due to their ultralarge bandwidths of…

Hardware accelerators are key to the efficiency and performance of system-on-chip (SoC) architectures. With high-level synthesis (HLS), designers can easily obtain several performance-cost trade-off implementations for each component of a…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-12-24 Luca Piccolboni , Paolo Mantovani , Giuseppe Di Guglielmo , Luca P. Carloni

Gradient-based hyperparameter optimization has earned a widespread popularity in the context of few-shot meta-learning, but remains broadly impractical for tasks with long horizons (many gradient steps), due to memory scaling and gradient…

Machine Learning · Computer Science 2021-10-01 Paul Micaelli , Amos Storkey

Small-molecule identification from tandem mass spectrometry (MS/MS) remains a bottleneck in untargeted settings where spectral libraries are incomplete. While deep learning offers a solution, current approaches typically fall into two…

Machine Learning · Computer Science 2026-03-05 Yinkai Wang , Yan Zhou Chen , Xiaohui Chen , Li-Ping Liu , Soha Hassoun

The Square Kilometre Array (SKA), which will be the world's largest radio telescope, will enhance and boost a large number of science projects, including the search for pulsars. The frequency domain acceleration search is an efficient…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-01-07 Haomiao Wang , Prabu Thiagaraj , Oliver Sinnen

In neuromorphic engineering, computation is commonly performed asynchronously, mimicking the way in which nervous systems process information: spike by spike. The Neuromorphic Auditory Sensor (NAS) has been implemented under this principle:…

Audio and Speech Processing · Electrical Eng. & Systems 2024-10-30 Angel Jimenez-Fernandez , Daniel Gutierrez-Galan , Antonio Rios-Navarro , Juan Pedro Dominguez-Morales , Gabriel Jimenez-Moreno

Scan-based operations, such as backstage compaction and value filtering, have emerged as the main bottleneck for LSM-Trees in supporting contemporary data-intensive applications. For slower external storage devices, such as HDD and SATA…

Databases · Computer Science 2025-08-19 Jianfeng Huang , Ziyao Wang , Lin Yuan , Jiajie Wen , Yihao Cao , Dongjing Miao , Yong Wang , Jiahao Zhang