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Cancer is one of the leading causes of death worldwide, making the development of rapid, minimally invasive, label-free and scalable diagnostic strategies a major challenge in modern oncology. In this context, spectroscopic liquid biopsy…

Recent neuroimaging studies that focus on predicting brain disorders via modern machine learning approaches commonly include a single modality and rely on supervised over-parameterized models.However, a single modality provides only a…

Joint embeddings between medical imaging modalities and associated radiology reports have the potential to offer significant benefits to the clinical community, ranging from cross-domain retrieval to conditional generation of reports to the…

Machine Learning · Computer Science 2018-11-28 Tzu-Ming Harry Hsu , Wei-Hung Weng , Willie Boag , Matthew McDermott , Peter Szolovits

Survival analysis, as a challenging task, requires integrating Whole Slide Images (WSIs) and genomic data for comprehensive decision-making. There are two main challenges in this task: significant heterogeneity and complex inter- and…

Image and Video Processing · Electrical Eng. & Systems 2024-06-17 Conghao Xiong , Hao Chen , Hao Zheng , Dong Wei , Yefeng Zheng , Joseph J. Y. Sung , Irwin King

Analyzing high resolution whole slide images (WSIs) with regard to information across multiple scales poses a significant challenge in digital pathology. Multi-instance learning (MIL) is a common solution for working with high resolution…

Deep learning for medical image classification faces three major challenges: 1) the number of annotated medical images for training are usually small; 2) regions of interest (ROIs) are relatively small with unclear boundaries in the whole…

Computer Vision and Pattern Recognition · Computer Science 2019-10-23 Shaohua Li , Yong Liu , Xiuchao Sui , Cheng Chen , Gabriel Tjio , Daniel Shu Wei Ting , Rick Siow Mong Goh

Automatic radiology report generation can alleviate the workload for physicians and minimize regional disparities in medical resources, therefore becoming an important topic in the medical image analysis field. It is a challenging task, as…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Xinyi Wang , Grazziela Figueredo , Ruizhe Li , Wei Emma Zhang , Weitong Chen , Xin Chen

Supervised learning tasks such as cancer survival prediction from gigapixel whole slide images (WSIs) are a critical challenge in computational pathology that requires modeling complex features of the tumor microenvironment. These learning…

Image and Video Processing · Electrical Eng. & Systems 2022-11-22 Iain Carmichael , Andrew H. Song , Richard J. Chen , Drew F. K. Williamson , Tiffany Y. Chen , Faisal Mahmood

Benefiting from the powerful expressive capability of graphs, graph-based approaches have been popularly applied to handle multi-modal medical data and achieved impressive performance in various biomedical applications. For disease…

Machine Learning · Computer Science 2022-03-14 Shuai Zheng , Zhenfeng Zhu , Zhizhe Liu , Zhenyu Guo , Yang Liu , Yuchen Yang , Yao Zhao

Breast cancer is the most common invasive cancer in women. Besides the primary B-mode ultrasound screening, sonographers have explored the inclusion of Doppler, strain and shear-wave elasticity imaging to advance the diagnosis. However,…

Image and Video Processing · Electrical Eng. & Systems 2020-08-11 Wang Jian , Miao Juzheng , Yang Xin , Li Rui , Zhou Guangquan , Huang Yuhao , Lin Zehui , Xue Wufeng , Jia Xiaohong , Zhou Jianqiao , Huang Ruobing , Ni Dong

Diagnostic prediction and clinical reasoning are critical tasks in healthcare applications. While Large Language Models (LLMs) have shown strong capabilities in commonsense reasoning, they still struggle with diagnostic reasoning due to…

Computation and Language · Computer Science 2026-04-28 Yimin Deng , Zhenxi Lin , Yejing Wang , Guoshuai Zhao , Pengyue Jia , Zichuan Fu , Derong Xu , Yefeng Zheng , Xiangyu Zhao , Li Zhu , Xian Wu , Xueming Qian

Machine learning (ML) applications in medical artificial intelligence (AI) systems have shifted from traditional and statistical methods to increasing application of deep learning models. This survey navigates the current landscape of…

Machine Learning · Computer Science 2024-01-23 Elisa Warner , Joonsang Lee , William Hsu , Tanveer Syeda-Mahmood , Charles Kahn , Olivier Gevaert , Arvind Rao

Multimodal language models (MLMs) show promise for clinical decision support and diagnostic reasoning, raising the prospect of end-to-end automated medical image interpretation. However, clinicians are highly selective in adopting AI tools;…

Artificial Intelligence · Computer Science 2025-08-06 Mahtab Bigverdi , Wisdom Ikezogwo , Kevin Zhang , Hyewon Jeong , Mingyu Lu , Sungjae Cho , Linda Shapiro , Ranjay Krishna

Advances in optical microscopy scanning have significantly contributed to computational pathology (CPath) by converting traditional histopathological slides into whole slide images (WSIs). This development enables comprehensive digital…

Image and Video Processing · Electrical Eng. & Systems 2024-11-19 Xitong Ling , Yuanyuan Lei , Jiawen Li , Junru Cheng , Wenting Huang , Tian Guan , Jian Guan , Yonghong He

We introduce a novel uncertainty-aware multimodal segmentation framework that leverages both radiological images and associated clinical text for precise medical diagnosis. We propose a Modality Decoding Attention Block (MoDAB) with a…

Computer Vision and Pattern Recognition · Computer Science 2026-02-23 Aryan Das , Tanishq Rachamalla , Koushik Biswas , Swalpa Kumar Roy , Vinay Kumar Verma

Multimodal pathology-genomic analysis is critical for cancer survival prediction. However, existing approaches predominantly integrate formalin-fixed paraffin-embedded (FFPE) slides with genomic data, while neglecting the availability of…

Computer Vision and Pattern Recognition · Computer Science 2025-06-25 Mingcheng Qu , Guang Yang , Donglin Di , Yue Gao , Tonghua Su , Yang Song , Lei Fan

Interpreting machine learning model decisions is crucial for high-risk applications like healthcare. In digital pathology, large whole slide images (WSIs) are decomposed into smaller tiles and tile-derived features are processed by…

Image and Video Processing · Electrical Eng. & Systems 2024-07-03 Tomé Albuquerque , Anil Yüce , Markus D. Herrmann , Alvaro Gomariz

The use of machine learning (ML) for cancer staging through medical image analysis has gained substantial interest across medical disciplines. When accompanied by the innovative federated learning (FL) framework, ML techniques can further…

Machine Learning · Computer Science 2024-10-10 Kasra Borazjani , Naji Khosravan , Leslie Ying , Seyyedali Hosseinalipour

In recent years, many mammographic image analysis methods have been introduced for improving cancer classification tasks. Two major issues of mammogram classification tasks are leveraging multi-view mammographic information and…

Computer Vision and Pattern Recognition · Computer Science 2023-09-08 Thanh-Huy Nguyen , Quang Hien Kha , Thai Ngoc Toan Truong , Ba Thinh Lam , Ba Hung Ngo , Quang Vinh Dinh , Nguyen Quoc Khanh Le

Fine-grained classification of whole slide images (WSIs) is essential in precision oncology, enabling precise cancer diagnosis and personalized treatment strategies. The core of this task involves distinguishing subtle morphological…

Computer Vision and Pattern Recognition · Computer Science 2025-04-07 Cheng Jin , Luyang Luo , Huangjing Lin , Jun Hou , Hao Chen
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