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Spike sorting is an essential process in neural recording, which identifies and separates electrical signals from individual neurons recorded by electrodes in the brain, enabling researchers to study how specific neurons communicate and…

Neurons and Cognition · Quantitative Biology 2025-12-23 Yimu Zhang , Dongqi Han , Yansen Wang , Zhenning Lv , Yu Gu , Dongsheng Li

Objective. Spike sorting, a critical step in neural data processing, aims to classify spiking events from single electrode recordings based on different waveforms. This study aims to develop a novel online spike sorter, NeuSort, using…

Neural and Evolutionary Computing · Computer Science 2023-09-19 Hang Yu , Yu Qi , Gang Pan

Spike sorting is a critical process for decoding large-scale neural activity from extracellular recordings. The advancement of neural probes facilitates the recording of a high number of neurons with an increase in channel counts, arising a…

Signal Processing · Electrical Eng. & Systems 2025-01-31 Yuntao Han , Yihan Pan , Xiongfei Jiang , Cristian Sestito , Shady Agwa , Themis Prodromakis , Shiwei Wang

Extracellular recordings with multi-electrode arrays is one of the basic tools of contemporary neuroscience. These recordings are mostly used to monitor the activities, understood as sequences of emitted action potentials, of many…

Computational Engineering, Finance, and Science · Computer Science 2014-12-22 Christophe Pouzat , Georgios Is. Detorakis

Reliable spike detection and sorting, the process of assigning each detected spike to its originating neuron, is an essential step in the analysis of extracellular electrical recordings from neurons. The volume and complexity of the data…

Neurons and Cognition · Quantitative Biology 2018-09-05 Matthias H. Hennig , Cole Hurwitz , Martino Sorbaro

Objective: Spike sorting is a fundamental step in analysing extracellular recordings, enabling the isolation of single-neuron activity. However, it remains a challenging problem because extracellular traces mix overlapping spikes from…

Signal Processing · Electrical Eng. & Systems 2025-06-12 Vasileios Georgiadis , Panagiotis C. Petrantonakis

Spike sorting is essential for extracting neuronal information from neural signals and understanding brain function. With the advent of high-density microelectrode arrays (HDMEAs), the challenges and opportunities in multi-channel spike…

Signal Processing · Electrical Eng. & Systems 2024-12-30 Yuntao Han , Shiwei Wang , Alister Hamilton

Spike sorting is a crucial step in decoding multichannel extracellular neural signals, enabling the identification of individual neuronal activity. A key challenge in brain-machine interfaces (BMIs) is achieving real-time, low-power spike…

Neural and Evolutionary Computing · Computer Science 2025-07-01 Alexis Melot , Sean U. N. Wood , Yannick Coffinier , Pierre Yger , Fabien Alibart

Spike sorting refers to the problem of assigning action potentials observed in extra-cellular recordings of neural activity to the neuron(s) from which they originate. We cast this problem as one of learning a convolutional dictionary from…

Methodology · Statistics 2018-06-07 Andrew H. Song , Francisco Flores , Demba Ba

Spike sorting algorithms are used to separate extracellular recordings of neuronal populations into single-unit spike activities. The development of customized hardware implementing spike sorting algorithms is burgeoning. However, there is…

Machine Learning · Computer Science 2025-01-30 Tim Zhang , Corey Lammie , Mostafa Rahimi Azghadi , Amirali Amirsoleimani , Majid Ahmadi , Roman Genov

Many previous works in spike sorting study spike classification and compression independently. In this paper, a novel algorithm is proposed called MetaSort to address these two problems. To deal with compression, a novel adaptive level…

Signal Processing · Electrical Eng. & Systems 2026-03-10 Luca M. Meyer , Majid Zamani

Extracellular recordings are transient voltage fluctuations in the vicinity of neurons, serving as a fundamental modality in neuroscience for decoding brain activity at single-neuron resolution. Spike sorting, the process of attributing…

Signal Processing · Electrical Eng. & Systems 2026-01-13 Feng Cao , Zishuo Feng , Jicong Zhang , Wei Shi

Objective. Recent advancements in electrode designs and micro-fabrication technology has allowed existence of microelectrode arrays with hundreds of channels for single-cell recordings. In such electrophysiological recordings, each…

Developing electrophysiological recordings of brain neuronal activity and their analysis provide a basis for exploring the structure of brain function and nervous system investigation. The recorded signals are typically a combination of…

Neurons and Cognition · Quantitative Biology 2019-11-01 Sahar Hojjatinia , Constantino M. Lagoa

We propose a construction for joint feature learning and clustering of multichannel extracellular electrophysiological data across multiple recording periods for action potential detection and discrimination ("spike sorting"). Our…

Spikes in the membrane electrical potentials of neurons play a major role in the functioning of nervous systems of animals. Obtaining the spikes from different neurons has been a challenging problem for decades. Several schemes have been…

Quantitative Methods · Quantitative Biology 2016-02-11 Anupam Mitra , Anagh Pathak , Kaushik Majumdar

In this paper authors have presented a power efficient scheme for implementing a spike sorting module. Spike sorting is an important application in the field of neural signal acquisition for implantable biomedical systems whose function is…

Neural and Evolutionary Computing · Computer Science 2018-02-27 Anand Kumar Mukhopadhyay , Indrajit Chakrabarti , Arindam Basu , Mrigank Sharad

Spike sorting is a fundamental preprocessing step for many neuroscience studies which rely on the analysis of spike trains. In this paper, we present two unsupervised spike sorting algorithms based on discriminative subspace learning. The…

Computer Vision and Pattern Recognition · Computer Science 2014-08-25 Mohammad Reza Keshtkaran , Zhi Yang

Extracellular recordings are severely contaminated by a considerable amount of noise sources, rendering the denoising process an extremely challenging task that should be tackled for efficient spike sorting. To this end, we propose an…

Neurons and Cognition · Quantitative Biology 2021-12-13 Christodoulos Kechris , Alexandros Delitzas , Vasileios Matsoukas , Panagiotis C. Petrantonakis

Estimating neuron location from extracellular recordings is essential for developing advanced brain-machine interfaces. Accurate neuron localization improves spike sorting, which involves detecting action potentials and assigning them to…

Neurons and Cognition · Quantitative Biology 2025-08-20 Hao Zhao , Xinhe Zhang , Arnau Marin-Llobet , Xinyi Lin , Jia Liu
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