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Detecting Alzheimer's disease (AD) from narrative transcripts challenges large language models (LLMs): pre-training rarely covers this out-of-distribution task, and all transcript demos describe the same scene, producing highly homogeneous…

Computation and Language · Computer Science 2025-11-11 Puzhen Su , Haoran Yin , Yongzhu Miao , Jintao Tang , Shasha Li , Ting Wang

In recent years there has been a burgeoning interest in the use of computational methods to distinguish between elicited speech samples produced by patients with dementia, and those from healthy controls. The difference between perplexity…

Computation and Language · Computer Science 2020-06-30 Trevor Cohen , Serguei Pakhomov

Adult neurodivergence, including Attention-Deficit/Hyperactivity Disorder (ADHD), high-functioning Autism Spectrum Disorder (ASD), and Cognitive Disengagement Syndrome (CDS), is marked by substantial symptom overlap that limits the…

Neurons and Cognition · Quantitative Biology 2026-01-23 Francesco Chiappone , Davide Marocco , Nicola Milano

Early detection of Alzheimer's Disease (AD) is greatly beneficial to AD patients, leading to early treatments that lessen symptoms and alleviating financial burden of health care. As one of the leading signs of AD, language capability…

Computation and Language · Computer Science 2025-10-17 Yangyang Li

Dementia is a syndrome characterised by the decline of different cognitive abilities. Alzheimer's Disease (AD) is the most common dementia affecting cognitive domains such as memory and learning, perceptual-motion or executive function.…

Computer Vision and Pattern Recognition · Computer Science 2018-10-26 Juan Manuel Fernández Montenegro

Alzheimer's Disease (AD) is a severe brain disorder, destroying memories and brain functions. AD causes chronically, progressively, and irreversibly cognitive declination and brain damages. The reliable and effective evaluation of early…

Image and Video Processing · Electrical Eng. & Systems 2021-01-07 Kuo Yang , Emad A. Mohammed

It is acknowledged that the most common cause of dementia worldwide is Alzheimer's disease (AD). This condition progresses in severity from mild to severe and interferes with people's everyday routines. Early diagnosis plays a critical role…

Image and Video Processing · Electrical Eng. & Systems 2024-09-30 Sajjad Aghasi Javid , Mahmood Mohassel Feghhi

As artificial neural networks grow in complexity, understanding their inner workings becomes increasingly challenging, which is particularly important in healthcare applications. The intrinsic evaluation metrics of autoregressive neural…

Computation and Language · Computer Science 2024-06-06 Changye Li , Zhecheng Sheng , Trevor Cohen , Serguei Pakhomov

Speech datasets for identifying Alzheimer's disease (AD) are generally restricted to participants performing a single task, e.g. describing an image shown to them. As a result, models trained on linguistic features derived from such…

Machine Learning · Computer Science 2018-11-30 Aparna Balagopalan , Jekaterina Novikova , Frank Rudzicz , Marzyeh Ghassemi

Large language models (LLMs) can generate natural language texts for various domains and tasks, but their potential for clinical text mining, a domain with scarce, sensitive, and imbalanced medical data, is underexplored. We investigate…

Computation and Language · Computer Science 2024-02-23 Rumeng Li , Xun Wang , Hong Yu

The detection of Alzheimer's disease (AD) from spontaneous speech has attracted increasing attention while the sparsity of training data remains an important issue. This paper handles the issue by knowledge transfer, specifically from both…

Computation and Language · Computer Science 2024-04-02 Ziyun Cui , Wen Wu , Wei-Qiang Zhang , Ji Wu , Chao Zhang

Multi-modal biological, imaging, and neuropsychological markers have demonstrated promising performance for distinguishing Alzheimer's disease (AD) patients from cognitively normal elders. However, it remains difficult to early predict when…

Computer Vision and Pattern Recognition · Computer Science 2019-01-08 Hongming Li , Yong Fan

Alzheimer's Disease (AD) is the most common form of dementia in the United States. Sleep is one of the lifestyle-related factors that has been shown critical for optimal cognitive function in old age. However, there is a lack of research…

The most frequent kind of dementia of the nervous system, Alzheimer's disease, weakens several brain processes (such as memory) and eventually results in death. The clinical study uses magnetic resonance imaging to diagnose AD. Deep…

Image and Video Processing · Electrical Eng. & Systems 2023-10-30 Sarasadat Foroughipoor , Kimia Moradi , Hamidreza Bolhasani

A common neurodegenerative disease, Alzheimer's disease requires a precise diagnosis and efficient treatment, particularly in light of escalating healthcare expenses and the expanding use of artificial intelligence in medical diagnostics.…

Image and Video Processing · Electrical Eng. & Systems 2025-05-21 Soyabul Islam Lincoln , Mirza Mohd Shahriar Maswood

Cognitive decline is a sign of Alzheimer's disease (AD), and there is evidence that tracking a person's eye movement, using eye tracking devices, can be used for the automatic identification of early signs of cognitive decline. However,…

Computation and Language · Computer Science 2019-10-02 Bahman Mirheidari , Yilin Pan , Traci Walker , Markus Reuber , Annalena Venneri , Daniel Blackburn , Heidi Christensen

This paper is a submission to the Alzheimer's Dementia Recognition through Spontaneous Speech (ADReSS) challenge, which aims to develop methods that can assist in the automated prediction of severity of Alzheimer's Disease from speech data.…

Machine Learning · Computer Science 2021-06-18 Morteza Rohanian , Julian Hough , Matthew Purver

Dementia is a group of irreversible, chronic, and progressive neurodegenerative disorders resulting in impaired memory, communication, and thought processes. In recent years, clinical research advances in brain aging have focused on the…

Computation and Language · Computer Science 2021-02-25 Swati Padhee , Anurag Illendula , Megan Sadler , Valerie L. Shalin , Tanvi Banerjee , Krishnaprasad Thirunarayan , William L. Romine

Early detection is a crucial goal in the study of Alzheimer's Disease (AD). In this work, we describe several techniques to boost the performance of 3D deep convolutional neural networks (CNNs) trained to detect AD using structural brain…

Image and Video Processing · Electrical Eng. & Systems 2020-04-07 Sheng Liu , Chhavi Yadav , Carlos Fernandez-Granda , Narges Razavian

Alzheimer's disease (AD), defined as an abnormal buildup of amyloid plaques and tau tangles in the brain can be diagnosed with high accuracy based on protein biomarkers via PET or CSF analysis. However, due to the invasive nature of…

Machine Learning · Computer Science 2026-01-27 Megan A. Witherow , Michael L. Evans , Ahmed Temtam , Hamid R. Okhravi , Khan M. Iftekharuddin
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