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Training segmentation models for medical images continues to be challenging due to the limited availability of data annotations. Segment Anything Model (SAM) is a foundation model that is intended to segment user-defined objects of interest…

Computer Vision and Pattern Recognition · Computer Science 2023-08-09 Maciej A. Mazurowski , Haoyu Dong , Hanxue Gu , Jichen Yang , Nicholas Konz , Yixin Zhang

The Segment Anything Model (SAM) is a deep neural network foundational model designed to perform instance segmentation which has gained significant popularity given its zero-shot segmentation ability. SAM operates by generating masks based…

Computer Vision and Pattern Recognition · Computer Science 2024-04-19 Yona Falinie A. Gaus , Neelanjan Bhowmik , Brian K. S. Isaac-Medina , Toby P. Breckon

While the Segment Anything Model (SAM) excels in semantic segmentation for general-purpose images, its performance significantly deteriorates when applied to medical images, primarily attributable to insufficient representation of medical…

Computer Vision and Pattern Recognition · Computer Science 2023-11-07 Yiming Zhang , Tianang Leng , Kun Han , Xiaohui Xie

Medical image segmentation is fundamental for biomedical discovery. Existing methods lack generalizability and demand extensive, time-consuming manual annotation for new clinical application. Here, we propose MedSAM-3, a text promptable…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Anglin Liu , Rundong Xue , Xu R. Cao , Yifan Shen , Yi Lu , Xiang Li , Qianqian Chen , Jintai Chen

Recent advances in medical image segmentation have been driven by deep learning; however, most existing methods remain limited by modality-specific designs and exhibit poor adaptability to dynamic medical imaging scenarios. The Segment…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Guoping Xu , Christopher Kabat , You Zhang

Recent domain generalized semantic segmentation (DGSS) studies have achieved notable improvements by distilling semantic knowledge from Vision-Language Models (VLMs). However, they overlook the semantic misalignment between visual and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Seogkyu Jeon , Kibeom Hong , Hyeran Byun

The Segment Anything Model (SAM) has recently emerged as a groundbreaking foundation model for prompt-driven image segmentation tasks. However, both the original SAM and its medical variants require slice-by-slice manual prompting of target…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Yichi Zhang , Shiyao Hu , Sijie Ren , Chen Jiang , Yuan Cheng , Yuan Qi

The Segment Anything Model (SAM) has recently demonstrated significant potential in medical image segmentation. Although SAM is primarily trained on 2D images, attempts have been made to apply it to 3D medical image segmentation. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Fangda Chen , Jintao Tang , Pancheng Wang , Ting Wang , Shasha Li , Ting Deng

Due to the inherent flexibility of prompting, foundation models have emerged as the predominant force in the fields of natural language processing and computer vision. The recent introduction of the Segment Anything Model (SAM) signifies a…

Image and Video Processing · Electrical Eng. & Systems 2024-01-09 Yichi Zhang , Zhenrong Shen , Rushi Jiao

The Segment Anything Model (SAM) is a powerful foundation model that introduced revolutionary advancements in natural image segmentation. However, its performance remains sub-optimal when delineating the intricate structure of biomedical…

Image and Video Processing · Electrical Eng. & Systems 2023-10-05 Xiangru Li , Yifei Zhang , Liang Zhao

Deep learning-based medical image segmentation typically requires large amount of labeled data for training, making it less applicable in clinical settings due to high annotation cost. Semi-supervised learning (SSL) has emerged as an…

Image and Video Processing · Electrical Eng. & Systems 2025-03-03 Yichi Zhang , Bohao Lv , Le Xue , Wenbo Zhang , Yuchen Liu , Yu Fu , Yuan Cheng , Yuan Qi

In digital pathology, precise nuclei segmentation is pivotal yet challenged by the diversity of tissue types, staining protocols, and imaging conditions. Recently, the segment anything model (SAM) revealed overwhelming performance in…

Image and Video Processing · Electrical Eng. & Systems 2024-02-27 Zhen Chen , Qing Xu , Xinyu Liu , Yixuan Yuan

The goal of interactive image segmentation is to delineate specific regions within an image via visual or language prompts. Low-latency and high-quality interactive segmentation with diverse prompts remain challenging for existing…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Qin Liu , Jaemin Cho , Mohit Bansal , Marc Niethammer

This paper addresses the domain adaptation challenge for semantic segmentation in medical imaging. Despite the impressive performance of recent foundational segmentation models like SAM on natural images, they struggle with medical domain…

Computer Vision and Pattern Recognition · Computer Science 2025-01-14 Javier Gamazo Tejero , Moritz Schmid , Pablo Márquez Neila , Martin S. Zinkernagel , Sebastian Wolf , Raphael Sznitman

Surgical image segmentation is highly challenging, primarily due to scarcity of annotated data. Generalist prompted segmentation models like the Segment-Anything Model (SAM) can help tackle this task, but because they require image-specific…

Computer Vision and Pattern Recognition · Computer Science 2025-07-16 Aditya Murali , Farahdiba Zarin , Adrien Meyer , Pietro Mascagni , Didier Mutter , Nicolas Padoy

With the development of Deep Neural Networks (DNNs), many efforts have been made to handle medical image segmentation. Traditional methods such as nnUNet train specific segmentation models on the individual datasets. Plenty of recent…

Computer Vision and Pattern Recognition · Computer Science 2024-07-12 Xiaobao Wei , Jiajun Cao , Yizhu Jin , Ming Lu , Guangyu Wang , Shanghang Zhang

Domain adaptive segmentation (DAS) of numerous organelle instances from large-scale electron microscopy (EM) is a promising way to enable annotation-efficient learning. Inspired by SAM, we propose a promptable multitask framework, namely…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Jiabao Chen , Shan Xiong , Jialin Peng

Domain-generalized nuclei segmentation refers to the generalizability of models to unseen domains based on knowledge learned from source domains and is challenged by various image conditions, cell types, and stain strategies. Recently, the…

Image and Video Processing · Electrical Eng. & Systems 2025-07-03 Zhenye Lou , Qing Xu , Zekun Jiang , Xiangjian He , Zhen Chen , Yi Wang , Chenxin Li , Maggie M. He , Wenting Duan

While large visual models (LVM) demonstrated significant potential in image understanding, due to the application of large-scale pre-training, the Segment Anything Model (SAM) has also achieved great success in the field of image…

Computer Vision and Pattern Recognition · Computer Science 2024-12-31 Jiaqi Yang , Yaning Zhang , Jingxi Hu , Xiangjian He , Linlin Shen , Guoping Qiu

Segmenting 3D objects into parts is a long-standing challenge in computer vision. To overcome taxonomy constraints and generalize to unseen 3D objects, recent works turn to open-world part segmentation. These approaches typically transfer…

Computer Vision and Pattern Recognition · Computer Science 2026-02-27 Zhe Zhu , Le Wan , Rui Xu , Yiheng Zhang , Honghua Chen , Zhiyang Dou , Cheng Lin , Yuan Liu , Mingqiang Wei