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Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models trained for a specific task. Training such models…

Image and Video Processing · Electrical Eng. & Systems 2025-12-18 Anwai Archit , Luca Freckmann , Constantin Pape

Advances in fluorescence microscopy enable acquisition of 3D image volumes with better image quality and deeper penetration into tissue. Segmentation is a required step to characterize and analyze biological structures in the images and…

Computer Vision and Pattern Recognition · Computer Science 2019-04-16 Chichen Fu , Soonam Lee , David Joon Ho , Shuo Han , Paul Salama , Kenneth W. Dunn , Edward J. Delp

We propose a 3D convolutional neural network to simultaneously segment and detect cell nuclei in confocal microscopy images. Mirroring the co-dependency of these tasks, our proposed model consists of two serial components: the first part…

Image and Video Processing · Electrical Eng. & Systems 2018-09-07 Sundaresh Ram , Vicky T. Nguyen , Kirsten H. Limesand , Mert R. Sabuncu

Deep convolutional neural networks (CNNs) have been widely used for medical image segmentation. In most studies, only the output layer is exploited to compute the final segmentation results and the hidden representations of the deep learned…

Image and Video Processing · Electrical Eng. & Systems 2022-12-20 Sheng He , Yanfang Feng , P. Ellen Grant , Yangming Ou

In this work, we utilize image segmentation to visually identify blood vessels in retinal examination images. This process is typically carried out manually. However, we can employ heuristic methods and machine learning to automate or at…

Image and Video Processing · Electrical Eng. & Systems 2023-09-01 João Henrique Pereira Machado , Gilson Adamczuk Oliveira , Érick Oliveira Rodrigues

Medical image segmentation has become an essential technique in clinical and research-oriented applications. Because manual segmentation methods are tedious, and fully automatic segmentation lacks the flexibility of human intervention or…

Image and Video Processing · Electrical Eng. & Systems 2019-04-24 Kevin Karsch , Qing He , Ye Duan

Modeling the 3D structures of cells and tissues is crucial in biology. Sequential cross-sectional images from electron microscopy provide high-resolution intracellular structure information. The segmentation of complex cell structures…

Quantitative Methods · Quantitative Biology 2025-02-14 Jin Kousaka , Atsuko H. Iwane , Yuichi Togashi

Analyzing CT scans, MRIs and X-rays is pivotal in diagnosing and treating diseases. However, detecting and identifying abnormalities from such medical images is a time-intensive process that requires expert analysis and is prone to…

Image and Video Processing · Electrical Eng. & Systems 2025-03-14 Daniel Syomichev , Padmini Gopinath , Guang-Lin Wei , Eric Chang , Ian Gordon , Amanuel Seifu , Rahul Pemmaraju , Neehar Peri , James Purtilo

Medical image segmentation has advanced rapidly over the past two decades, largely driven by deep learning, which has enabled accurate and efficient delineation of cells, tissues, organs, and pathologies across diverse imaging modalities.…

Image and Video Processing · Electrical Eng. & Systems 2025-08-29 Guoping Xu , Jayaram K. Udupa , Jax Luo , Songlin Zhao , Yajun Yu , Scott B. Raymond , Hao Peng , Lipeng Ning , Yogesh Rathi , Wei Liu , You Zhang

Medical image segmentation assists in computer-aided diagnosis, surgeries, and treatment. Digitize tissue slide images are used to analyze and segment glands, nuclei, and other biomarkers which are further used in computer-aided medical…

Image and Video Processing · Electrical Eng. & Systems 2022-09-05 Saad Wazir , Muhammad Moazam Fraz

Fully convolutional neural networks (CNNs) have proven to be effective at representing and classifying textural information, thus transforming image intensity into output class masks that achieve semantic image segmentation. In medical…

Computer Vision and Pattern Recognition · Computer Science 2019-09-12 Ali Hatamizadeh , Demetri Terzopoulos , Andriy Myronenko

If we are ever to unravel the mysteries of brain function at its most fundamental level, we will need a precise understanding of how its component neurons connect to each other. Electron Microscopes (EM) can now provide the nanometer…

Computer Vision and Pattern Recognition · Computer Science 2016-09-28 Pascal Fua , Graham Knott

Background Analyzing images to accurately estimate the number of different cell types in the brain using automatic methods is a major objective in neuroscience. The automatic and selective detection and segmentation of neurons would be an…

Image and Video Processing · Electrical Eng. & Systems 2024-10-07 Antonio LaTorre , Lidia Alonso-Nanclares , José María Peña , Javier De Felipe

Automated cell segmentation is crucial for various biological and medical applications, facilitating tasks like cell counting, morphology analysis, and drug discovery. However, manual segmentation is time-consuming and prone to…

Machine Learning · Computer Science 2024-09-13 Aaron Rock Menezes , Bharath Ramsundar

Computer-aided medical image analysis plays a significant role in assisting medical practitioners for expert clinical diagnosis and deciding the optimal treatment plan. At present, convolutional neural networks (CNN) are the preferred…

Image and Video Processing · Electrical Eng. & Systems 2022-04-29 S Niyas , S J Pawan , M Anand Kumar , Jeny Rajan

Computer vision has shown promising results in medical image processing. Pneumothorax is a deadly condition and if not diagnosed and treated at time then it causes death. It can be diagnosed with chest X-ray images. We need an expert and…

Computer Vision and Pattern Recognition · Computer Science 2024-09-05 Karan Jakhar , Avneet Kaur , Meenu Gupta

Reconstruction of neuroanatomy is a fundamental problem in neuroscience. Stochastic expression of colors in individual cells is a promising tool, although its use in the nervous system has been limited due to various sources of variability…

Neurons and Cognition · Quantitative Biology 2017-01-24 Uygar Sümbül , Douglas Roussien , Fei Chen , Nicholas Barry , Edward S. Boyden , Dawen Cai , John P. Cunningham , Liam Paninski

Automatic detection and segmentation of objects in 2D and 3D microscopy data is important for countless biomedical applications. In the natural image domain, spatial embedding-based instance segmentation methods are known to yield…

Image and Video Processing · Electrical Eng. & Systems 2021-04-30 Manan Lalit , Pavel Tomancak , Florian Jug

Analysis of microscopy images can provide insight into many biological processes. One particularly challenging problem is cell nuclear segmentation in highly anisotropic and noisy 3D image data. Manually localizing and segmenting each and…

Computer Vision and Pattern Recognition · Computer Science 2013-09-18 Christian Widmer , Philipp Drewe , Xinghua Lou , Shefali Umrania , Stephanie Heinrich , Gunnar Rätsch

Automated sample preparation and electron microscopy enables acquisition of very large image data sets. These technical advances are of special importance to the field of neuroanatomy, as 3D reconstructions of neuronal processes at the nm…