Related papers: Beyond accuracy: quantifying the reliability of Mu…

We study a multiclass multiple instance learning (MIL) problem where the labels only suggest whether any instance of a class exists or does not exist in a training sample or example. No further information, e.g., the number of instances of…

Whole slide images, with their gigapixel-scale panoramas of tissue samples, are pivotal for precise disease diagnosis. However, their analysis is hindered by immense data size and scarce annotations. Existing MIL methods face challenges due…

Recent advances in attention-based multiple instance learning (MIL) have improved our insights into the tissue regions that models rely on to make predictions in digital pathology. However, the interpretability of these approaches is still…

We address the problem of \emph{instance label stability} in multiple instance learning (MIL) classifiers. These classifiers are trained only on globally annotated images (bags), but often can provide fine-grained annotations for image…

The comprehensive integration of machine learning healthcare models within clinical practice remains suboptimal, notwithstanding the proliferation of high-performing solutions reported in the literature. A predominant factor hindering…

In this work, we introduce a new information-theoretic perspective on Multiple Instance Learning (MIL) for parameter estimation with i.i.d. data, and show that MIL can outperform single-instance learners in low-signal regimes. Prior work…

In Multiple Instance Learning (MIL), models are trained using bags of instances, where only a single label is provided for each bag. A bag label is often only determined by a handful of key instances within a bag, making it difficult to…

Deep learning for medical image classification faces three major challenges: 1) the number of annotated medical images for training are usually small; 2) regions of interest (ROIs) are relatively small with unclear boundaries in the whole…

In digital pathology, the multiple instance learning (MIL) strategy is widely used in the weakly supervised histopathology whole slide image (WSI) classification task where giga-pixel WSIs are only labeled at the slide level. However,…

In the field of whole slide image (WSI) classification, multiple instance learning (MIL) serves as a promising approach, commonly decoupled into feature extraction and aggregation. In this paradigm, our observation reveals that…

Multiple Instance Learning (MIL) has been widely applied to medical imaging diagnosis, where bag labels are known and instance labels inside bags are unknown. Traditional MIL assumes that instances in each bag are independent samples from a…

Multiple instance learning (MIL)-based framework has become the mainstream for processing the whole slide image (WSI) with giga-pixel size and hierarchical image context in digital pathology. However, these methods heavily depend on a…

In pre-clinical pathology, there is a paradox between the abundance of raw data (whole slide images from many organs of many individual animals) and the lack of pixel-level slide annotations done by pathologists. Due to time constraints and…

Multiple instance learning (MIL) can reduce the need for costly annotation in tasks such as semantic segmentation by weakening the required degree of supervision. We propose a novel MIL formulation of multi-class semantic segmentation…

Developing self-supervised learning (SSL) models that can learn universal and transferable representations of H&E gigapixel whole-slide images (WSIs) is becoming increasingly valuable in computational pathology. These models hold the…

Histologic assessment of ulcerative colitis (UC) activity is an important endpoint in clinical trials and routine care, but manual grading with indices such as the Nancy histological index (NHI) is time-consuming and prone to observer…

Fetal abdominal malformations are serious congenital anomalies that require accurate diagnosis to guide pregnancy management and reduce mortality. Although AI has demonstrated significant potential in medical diagnosis, its application to…

Recent advancements in computational pathology and artificial intelligence have significantly improved whole slide image (WSI) classification. However, the gigapixel resolution of WSIs and the scarcity of manual annotations present…

In statistical learning, many problem formulations have been proposed so far, such as multi-class learning, complementarily labeled learning, multi-label learning, multi-task learning, which provide theoretical models for various real-world…

Multiple instance learning exhibits a powerful approach for whole slide image-based diagnosis in the absence of pixel- or patch-level annotations. In spite of the huge size of hole slide images, the number of individual slides is often…