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The regulatory approval and broad clinical deployment of medical AI have been hampered by the perception that deep learning models fail in unpredictable and possibly catastrophic ways. A lack of statistically rigorous uncertainty…

Machine Learning · Computer Science 2022-07-07 Charles Lu , Anastasios N. Angelopoulos , Stuart Pomerantz

Semi-supervised image classification has shown substantial progress in learning from limited labeled data, but recent advances remain largely untested for clinical applications. Motivated by the urgent need to improve timely diagnosis of…

Computer Vision and Pattern Recognition · Computer Science 2021-08-03 Zhe Huang , Gary Long , Benjamin Wessler , Michael C. Hughes

Aortic stenosis (AS) is a life-threatening condition caused by a narrowing of the aortic valve, leading to impaired blood flow. Despite its high prevalence, access to echocardiography (echo), the gold-standard diagnostic tool, is often…

Computer Vision and Pattern Recognition · Computer Science 2025-09-04 Armin Saadat , Nima Hashemi , Hooman Vaseli , Michael Y. Tsang , Christina Luong , Michiel Van de Panne , Teresa S. M. Tsang , Purang Abolmaesumi

Carotid artery stenosis is the narrowing of carotid arteries, which supplies blood to the neck and head. In this work, we train a model to predict the severity of the stenosis blockage based on SRUC criteria variables and other patient…

Quantitative Methods · Quantitative Biology 2021-08-03 Yiqun Diao , Oliver Zhao , Priya Kothapalli , Peter Monteleone , Chandrajit Bajaj

How to accurately classify and diagnose whether an individual has Coronary Stenosis (CS) without invasive physical examination? This problem has not been solved satisfactorily. To this end, the four machine learning (ML) algorithms, i.e.,…

Tissues and Organs · Quantitative Biology 2021-09-08 Weijun Zhu , Fengyuan Lu , Xiaoyu Yang , En Li

Aortic stenosis (AS) is a degenerative valve condition that causes substantial morbidity and mortality. This condition is under-diagnosed and under-treated. In clinical practice, AS is diagnosed with expert review of transthoracic…

Image and Video Processing · Electrical Eng. & Systems 2024-04-08 Zhe Huang , Benjamin S. Wessler , Michael C. Hughes

We present a novel multimodal deep learning framework for cardiac resynchronisation therapy (CRT) response prediction from 2D echocardiography and cardiac magnetic resonance (CMR) data. The proposed method first uses the `nnU-Net'…

Image and Video Processing · Electrical Eng. & Systems 2021-07-23 Esther Puyol-Antón , Baldeep S. Sidhu , Justin Gould , Bradley Porter , Mark K. Elliott , Vishal Mehta , Christopher A. Rinaldi , Andrew P. King

Assessing the severity of stenoses in coronary angiography is critical to the patient's health, as coronary stenosis is an underlying factor in heart failure. Current practice for grading coronary lesions, i.e. fractional flow reserve (FFR)…

Image and Video Processing · Electrical Eng. & Systems 2024-09-24 Raffaele Mineo , Amelia Sorrenti , Federica Proietto Salanitri

The interpretation of chest radiographs is an essential task for the detection of thoracic diseases and abnormalities. However, it is a challenging problem with high inter-rater variability and inherent ambiguity due to inconclusive…

Computer Vision and Pattern Recognition · Computer Science 2019-06-20 Florin C. Ghesu , Bogdan Georgescu , Eli Gibson , Sebastian Guendel , Mannudeep K. Kalra , Ramandeep Singh , Subba R. Digumarthy , Sasa Grbic , Dorin Comaniciu

Deep neural networks are increasingly being used for computer-aided diagnosis, but erroneous diagnoses can be extremely costly for patients. We propose a learning to defer with uncertainty (LDU) algorithm which identifies patients for whom…

Machine Learning · Computer Science 2021-11-30 Jessie Liu , Blanca Gallego , Sebastiano Barbieri

Deep learning models have gained increasing adoption in medical image analysis. However, these models often produce overconfident predictions, which can compromise clinical accuracy and reliability. Bridging the gap between high-performance…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Jutika Borah , Hidam Kumarjit Singh

Predictive uncertainty-a model's self awareness regarding its accuracy on an input-is key for both building robust models via training interventions and for test-time applications such as selective classification. We propose a novel…

Machine Learning · Computer Science 2024-01-04 Nishant Jain , Karthikeyan Shanmugam , Pradeep Shenoy

The interpretation of medical images is a challenging task, often complicated by the presence of artifacts, occlusions, limited contrast and more. Most notable is the case of chest radiography, where there is a high inter-rater variability…

Evaluation of predictive deep learning (DL) models beyond conventional performance metrics has become increasingly important for applications in sensitive environments like healthcare. Such models might have the capability to encode and…

Coronary stenosis is a major risk factor for ischemic heart events leading to increased mortality, and medical treatments for this condition require meticulous, labor-intensive analysis. Coronary angiography provides critical visual cues…

Image and Video Processing · Electrical Eng. & Systems 2025-08-04 Sumin Seo , In Kyu Lee , Hyun-Woo Kim , Jaesik Min , Chung-Hwan Jung

AI-powered stethoscopes offer a promising alternative for screening rheumatic heart disease (RHD), particularly in regions with limited diagnostic infrastructure. Early detection is vital, yet echocardiography, the gold standard tool,…

2D echocardiography is the most common imaging modality for cardiovascular diseases. The portability and relatively low-cost nature of Ultrasound (US) enable the US devices needed for performing echocardiography to be made widely available.…

Computer Vision and Pattern Recognition · Computer Science 2020-05-20 Lavsen Dahal , Aayush Kafle , Bishesh Khanal

The evaluation of obstructions (stenosis) in coronary arteries is currently done by a physician's visual assessment of coronary angiography video sequences. It is laborious, and can be susceptible to interobserver variation. Prior studies…

Image and Video Processing · Electrical Eng. & Systems 2021-02-01 Chengyang Zhou , Thao Vy Dinh , Heyi Kong , Jonathan Yap , Khung Keong Yeo , Hwee Kuan Lee , Kaicheng Liang

Coronary angiography is considered to be a safe tool for the evaluation of coronary artery disease and perform in approximately 12 million patients each year worldwide. [1] In most cases, angiograms are manually analyzed by a cardiologist.…

Computer Vision and Pattern Recognition · Computer Science 2017-06-07 Stanislav Filippov , Arsenii Moiseev , Andronenko Andrey

Coronary artery disease leading up to stenosis, the partial or total blocking of coronary arteries, is a severe condition that affects millions of patients each year. Automated identification and classification of stenosis severity from…

Image and Video Processing · Electrical Eng. & Systems 2021-03-05 Dinis L. Rodrigues , Miguel Nobre Menezes , Fausto J. Pinto , Arlindo L. Oliveira
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