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The notion of causal effect is fundamental across many scientific disciplines. Traditionally, quantitative researchers have studied causal effects at the level of variables; for example, how a certain drug dose (W) causally affects a…

Methodology · Statistics 2026-04-07 Junhyung Park , Yuqing Zhou

In experimental and observational data settings, researchers often have limited knowledge of the reasons for missing outcomes. To address this uncertainty, we propose bounds on causal effects for missing outcomes, accommodating the scenario…

Methodology · Statistics 2026-03-19 Max Rubinstein , Denis Agniel , Larry Han , Marcela Horvitz-Lennon , Sharon-Lise Normand

Propensity scores are often used for stratification of treatment and control groups of subjects in observational data to remove confounding bias when estimating of causal effect of the treatment on an outcome in so-called potential outcome…

Statistics Theory · Mathematics 2018-04-24 Priyantha Wijayatunga

Probabilities of causation play a crucial role in modern decision-making. Pearl defined three binary probabilities of causation, the probability of necessity and sufficiency (PNS), the probability of sufficiency (PS), and the probability of…

Artificial Intelligence · Computer Science 2022-10-18 Ang Li , Judea Pearl

Probabilities of causation (PoCs) are fundamental quantities for counterfactual analysis and personalized decision making. However, existing analytical results are largely confined to binary settings. This paper extends PoCs to multi-valued…

Artificial Intelligence · Computer Science 2026-02-02 Xin Shu , Shuai Wang , Ang Li

The propensity score is a common tool for estimating the causal effect of a binary treatment in observational data. In this setting, matching, subclassification, imputation, or inverse probability weighting on the propensity score can…

Methodology · Statistics 2018-01-03 Michael J Lopez , Roee Gutman

The current best practice approach for the retrospective diagnosis of adverse drug events (ADEs) in hospitalized patients relies on a full patient chart review and a formal causality assessment by multiple medical experts. This evaluation…

We study causal inference under case-control and case-population sampling. Specifically, we focus on the binary-outcome and binary-treatment case, where the parameters of interest are causal relative and attributable risks defined via the…

Econometrics · Economics 2023-10-24 Sung Jae Jun , Sokbae Lee

Evaluating joint probabilities of potential outcomes and observed variables, and their linear combinations, is a fundamental challenge in causal inference. This paper addresses the bounding and identification of these probabilities in…

Machine Learning · Statistics 2026-02-24 Naoya Hashimoto , Yuta Kawakami , Jin Tian

In the causal adjustment setting, variable selection techniques based on either the outcome or treatment allocation model can result in the omission of confounders or the inclusion of spurious variables in the propensity score. We propose a…

Statistics Theory · Mathematics 2014-06-06 Ashkan Ertefaie , Masoud Asgharian , David A. Stephens

Researchers are often interested in treatment effects on outcomes that are only defined conditional on a post-treatment event status. For example, in a study of the effect of different cancer treatments on quality of life at end of…

Estimation of individual treatment effects is commonly used as the basis for contextual decision making in fields such as healthcare, education, and economics. However, it is often sufficient for the decision maker to have estimates of…

Machine Learning · Computer Science 2020-08-13 Maggie Makar , Fredrik D. Johansson , John Guttag , David Sontag

Micro-randomized trials are commonly conducted for optimizing mobile health interventions such as push notifications for behavior change. In analyzing such trials, causal excursion effects are often of primary interest, and their estimation…

Methodology · Statistics 2024-08-19 Yihan Bao , Lauren Bell , Elizabeth Williamson , Claire Garnett , Tianchen Qian

This paper addresses the problem of estimating causal effects when adjustment variables in the back-door or front-door criterion are partially observed. For such scenarios, we derive bounds on the causal effects by solving two non-linear…

Methodology · Statistics 2021-06-24 Ang Li , Judea Pearl

Researchers are often challenged with assessing the impact of an intervention on an outcome of interest in situations where the intervention is non-randomised, the intervention is only applied to one or few units, the intervention is…

Attributing an observed outcome to its root cause is a central task in domains ranging from medical diagnosis to engineering fault diagnosis. Existing approaches either equate the root cause with a root node of the causal graph, as in…

Methodology · Statistics 2026-05-13 Zitong Lu , Zhi Geng , Wei Li , Min Xie

This tutorial provides a concise introduction to modern causal modeling by integrating potential outcomes and graphical methods. We motivate causal questions such as counterfactual reasoning under interventions and define binary treatments…

Methodology · Statistics 2025-06-27 Gauranga Kumar Baishya

Applied researchers in biomedicine and related fields are often interested in estimating the causal effect of a treatment or intervention. Although randomized clinical trials are considered the gold standard for establishing causal effects,…

In contrast to evaluating treatment effects, causal attribution analysis focuses on identifying the key factors responsible for an observed outcome. For two binary exposure variables and a binary outcome variable, researchers need to assess…

Applications · Statistics 2026-01-21 Shanshan Luo , Wei Li , Xueli Wang , Shaojie Wei , Zhi Geng

Instrumental variables have proven useful, in particular within the social sciences and economics, for making inference about the causal effect of a random variable, B, on another random variable, C, in the presence of unobserved…

Methodology · Statistics 2012-06-26 Roland R. Ramsahai