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Historically employed spectroscopic architectures used for large field of view mapping spectroscopy in millimetere and sub-millimetre astronomy suffer from significant drawbacks. On-chip filterbank spectrometers are a promising technology…

Instrumentation and Methods for Astrophysics · Physics 2026-04-14 Chris S. Benson , Peter S. Barry , Patrick Ashworth , Harry Gordon-Moys , Kirit S. Karkare , Izaak Morris , Gethin Robson

Total internal reflection fluorescence (TIRF) microscopy and its variants are key technologies for visualizing the dynamics of single molecules or organelles in live cells. Yet, truely quantitative TIRF remains problematic. One unknown…

Biological Physics · Physics 2017-06-07 Maia Brunstein , Lopamudra Roy , Martin Oheim

Fourier transform spectroscopy (FTS) has been widely used in a variety of fields in research, industry, and medicine due to its high signal-to-noise ratio, simultaneous acquisition of signals in a broad spectrum, and versatility for…

The optical elements comprised of sub-diffractive light scatterers, or metasurfaces, hold a promise to reduce the footprint and unfold new functionalities of optical devices. A particular interest is focused on metasurfaces for manipulation…

Dispersive Fourier transformation is a powerful technique in which spectral information is mapped into the time domain using chromatic dispersion. It replaces a spectrometer with an electronic digitizer, and enables real-time spectroscopy.…

Optics · Physics 2009-11-13 J. Chou , D. R. Solli , B. Jalali

IR spectroscopy has been widely used for chemical identification and quantitative analysis of reactions occurring in a specific time and space domains by measuring an average signal of the entire system1. Achieving IR measurements with…

In order to efficiently image a non-absorbing sample (a phase object), dedicated phase contrast optics are required. Typically, these optics are designed with the assumption that the sample is weakly scattering, implying a linear relation…

Optics · Physics 2020-10-22 Stewart Koppell , Mark Kasevich

Resampling by interpolation is the traditional method to process interferograms from non-uniformly sampled Fourier transform spectrometers. The non-uniform fast Fourier transform (NUFFT) is an alternative approach that has been mostly…

Instrumentation and Detectors · Physics 2024-12-10 Muqian Wen , John Houlihan

Chemical imaging provides information about the distribution of chemicals within a target. When combined with structural information about the target, in situ chemical imaging opens the door to applications ranging from tissue…

Image and Video Processing · Electrical Eng. & Systems 2020-12-02 Luke Pfister , Rohit Bhargava , Yoram Bresler , P. Scott Carney

Infrared Imaging Spectrograph (IRIS) is the first light instrument for the Thirty Meter Telescope (TMT) that consists of a near-infrared (0.84 to 2.4 micron) imager and integral field spectrograph (IFS) which operates at the…

Edge-enhanced imaging is critical for visualizing weakly absorbing and transparent objects. Extending this functionality into the mid-infrared (MIR) region enables chemical sensitivity and improved imaging performance for biomedical,…

Mid-infrared spectroscopy probes molecular vibrations to identify chemical species and functional groups. Therefore, mid-infrared hyperspectral imaging is one of the most powerful and promising candidates for chemical imaging using optical…

Optics · Physics 2023-07-06 Yue Zhao , Shota Kusama , Yuji Furutani , Wei-Hong Huang , Chih-Wei Luo , Takao Fuji

We have made a preliminary analysis of the results about the eVects on tumoral cell line (lymphoid T cell line Jurkat) induced by UVB radiation (dose of 310 mJ/cm^2) with and without a vegetable mixture. In the present study, we have used…

We report on a technically simple approach to achieve high-resolution and high-sensitivity Fourier-domain OCT imaging in the mid-infrared range. The proposed OCT system employs an InF3 supercontinuum source. A specially designed dispersive…

Optics · Physics 2021-09-15 Ivan Zorin , Paul Gattinger , Andrii Prylepa , Bettina Heise

Millimetre-wave observations represent an important tool for Cosmology studies. The Line Intensity Mapping (LIM) technique has been proposed to map in three dimensions the specific intensity due to line (e.g. [CII], CO) emission, for…

Instrumentation and Methods for Astrophysics · Physics 2023-08-29 Usasi Chowdhury , Florence Levy-Bertrand , Martino Calvo , Johannes Goupy , Alessandro Monfardini

Structured illumination microscopy (SIM) has attained high spatiotemporal delineation of subcellular architecture, yet offers limited insight into chemical composition. We develop Chem-SIM, a structured-illumination fluorescence detected…

Fluorescence microscopy is a powerful tool for imaging biological samples with molecular specificity. In contrast, phase microscopy provides label-free measurement of the sample's refractive index (RI), which is an intrinsic optical…

Optics · Physics 2022-01-26 Yi Xue , David Ren , Laura Waller

This article presents a method to perform diffraction tomography in a standard microscope that includes an LED array for illumination. After acquiring a sequence of intensity-only images of a thick sample, a ptychography-based…

Optics · Physics 2015-10-30 Roarke Horstmeyer , Changhuei Yang

In this paper, the design and the characterization of a novel interrogator based on integrated Fourier transform (FT) spectroscopy is presented. To the best of our knowledge, this is the first integrated FT spectrometer used for the…

Rapid identification of bacterial species is crucial in medicine and food hygiene. In order to achieve rapid and label-free identification of bacterial species at the single bacterium level, we propose and experimentally demonstrate an…