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The principles and practice of astronomical imaging Fourier transform spectroscopy (FTS) at far-infrared wavelengths are described. The Mach-Zehnder interferometer design has been widely adopted for current and future imaging FTS…

Instrumentation and Methods for Astrophysics · Physics 2013-10-10 David A. Naylor , Brad G. Gom , Matthijs H. D. van der Wiel , Gibion Makiwa

Sensing with undetected photons has become a vibrant, application-driven research domain with a special focus on the mid-infrared (mid-IR) wavelength region. Since the mid-IR contains spectral bands with highly specific and strong molecular…

Absolute quantity imaging of biomolecules on a single cell level is critical for measurement assurance in biosciences and bioindustries. While infrared (IR) transmission microscopy is a powerful label-free imaging modality capable of…

Quantitative Methods · Quantitative Biology 2024-03-29 Yow-Ren Chang , Seong-Min Kim , Young Jong Lee

We report a broadband long-wave infrared Fourier transform spectrometer with sensitivity exceeding that of previously reported direct-detection implementations. The system combines dual-comb spectroscopy with electro-optic sampling,…

Mid-infrared photo-induced force microscopy (IR-PiFM/PiF-IR) enables high-resolution chemical imaging of surfaces with lateral resolution less than 5 nm. Here are some answers to questions about the physical background, practical handling…

Materials Science · Physics 2026-05-05 Daniela Täuber

Here, we present a diffusion transformer (DiT)-based pixel super-resolution virtual staining approach to transform low-resolution FTIR microspectroscopic images of the unstained tissues into corresponding high-resolution H&E-stained images.…

Optics · Physics 2026-03-10 Yudong Tian , Xiangyu Zhao , Yuqing Liu , Bofei Yang , Chongzhao Wu

Total Internal Reflection Microscopy (TIRM) is a sensitive non-invasive technique to measure the interaction potentials between a colloidal particle and a wall with femtonewton resolution. The equilibrium distribution of the particle-wall…

Evanescent waves are central to many technologies such as near-field imaging that beats the diffraction limit and plasmonic devices. Frustrated total internal reflection (FTIR) is an experimental method commonly used to study evanescent…

The far-infrared (FIR) regime is one of the few wavelength ranges where no astronomical data with sub-arcsecond spatial resolution exist. Neither of the medium-term satellite projects like SPICA, Millimetron nor O.S.T. will resolve this…

Spatial resolution of most imaging devices is fundamentally restricted by diffraction. This limitation is manifested in the loss of high spatial frequency information contained in evanescent waves. As a result, conventional far-field optics…

Optics · Physics 2010-03-16 Leonid Alekseyev , Evgenii Narimanov , Jacob Khurgin

We propose an on-chip mid-infrared (MIR) photonic spectroscopy platform for aerosol characterization to obtain highly discriminatory information on the chemistry of aerosol particles. Sensing of aerosols is crucial for various…

Applied Physics · Physics 2020-05-12 Robin Singh , Peter Su , Lionel Kimerling , Anu Agarwal , Brian W Anthony

We use two femtosecond Erbium-doped fiber lasers with slightly different repetition rates to perform a modern type of Fourier transform spectroscopy without moving parts. The measurements are done in real time, and it takes less than 50…

Mid-infrared (MIR) spectroscopy is a powerful technique employed for a variety of applications, including gas sensing, industrial inspection, astronomy, surveillance, and imaging. Thin-film narrowband interference filters, targeted to…

Ovarian cancer detection has traditionally relied on a multi-step process that includes biopsy, tissue staining, and morphological analysis by experienced pathologists. While widely practiced, this conventional approach suffers from several…

Near-field infrared spectroscopy by elastic scattering of light from a probe tip resolves optical contrasts in materials at dramatically sub-wavelength scales across a broad energy range, with the demonstrated capacity for chemical…

Optical spectrum analysis is the cornerstone of spectroscopic sensing, optical network performance monitoring, and hyperspectral imaging. While conventional high-performance spectrometers used to perform such analysis are often large…

Applied Physics · Physics 2018-03-19 Derek M. Kita , Brando Miranda , David Favela , David Bono , Jerome Michon , Hongtao Lin , Tian Gu , Juejun Hu

Interpreting spectroscopy data is a critical bottleneck in automating chemical research and industrial characterization. Particularly within infrared (IR) spectroscopy, identifying compounds in complex, liquid-phase chemical mixtures…

Materials Science · Physics 2026-02-26 Yannah J. U. Melle , Thanh Nguyen , Jeffrey Lopez , Daniel Schwalbe-Koda

Novel techniques are currently being developed and established for the accurate chemical analysis and detection of single cancer cells, single embryos and single seeds by Fourier Transform Near Infrared (FT-NIR) Microspectroscopy, Fourier…

Tissues and Organs · Quantitative Biology 2007-05-23 I. C. Baianu , D. Costescu , N. E. Hofmann , S. S. Korban

Owing to its capacity for unique (bio)-chemical specificity, microscopy withmid-IR illumination holds tremendous promise for a wide range of biomedical and industrial applications. The primary limitation, however, remains detection; with…

We demonstrate a new computational illumination technique that achieves large space-bandwidth-time product, for quantitative phase imaging of unstained live samples in vitro. Microscope lenses can have either large field of view (FOV) or…

Optics · Physics 2015-10-16 Lei Tian , Ziji Liu , Li-Hao Yeh , Michael Chen , Jingshan Zhong , Laura Waller