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Reduced-order models (ROMs) allow for the simulation of blood flow in patient-specific vasculatures without the high computational cost and wait time associated with traditional computational fluid dynamics (CFD) models. Unfortunately, due…

Computational Engineering, Finance, and Science · Computer Science 2024-02-27 Natalia L. Rubio , Luca Pegolotti , Martin R. Pfaller , Eric F. Darve , Alison L. Marsden

Generally, reduced order models of fluid flows are obtained by projecting the Navier-Stokes equations onto a reduced subspace spanned by vector functions that carry the meaningful information of the dynamics. A common method to generate…

Fluid Dynamics · Physics 2023-09-22 M. Oulghelou , A. Ammar , R. Ayoub

Accurate and efficient modeling of cardiac blood flow is crucial for advancing data-driven tools in cardiovascular research and clinical applications. Recently, the accuracy and availability of computational fluid dynamics (CFD)…

Fluid Dynamics · Physics 2025-07-30 Eneko Lazpita , Jesus Garicano-Mena , Soledad Le Clainche

One possible way of making thermal processing controllable is to gather real-time information on the product's current state. Often, sensory equipment cannot capture all relevant information easily or at all. Digital Twins close this gap…

Computational Engineering, Finance, and Science · Computer Science 2022-09-08 Maximilian Kannapinn , Minh Khang Pham , Michael Schäfer

Hybrid physics-machine learning models are increasingly being used in simulations of transport processes. Many complex multiphysics systems relevant to scientific and engineering applications include multiple spatiotemporal scales and…

Fluid Dynamics · Physics 2021-06-09 Shady E. Ahmed , Omer San , Kursat Kara , Rami Younis , Adil Rasheed

A new deep-learning-based reduced-order modeling (ROM) framework is proposed for application in subsurface flow simulation. The reduced-order model is based on an existing embed-to-control (E2C) framework and includes an auto-encoder, which…

Computational Physics · Physics 2019-06-11 Zhaoyang Larry Jin , Yimin Liu , Louis J. Durlofsky

Digital twins are transforming the way we monitor, analyze, and control physical systems, but designing architectures that balance real-time responsiveness with heavy computational demands remains a challenge. Cloud-based solutions often…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-01-16 E. Iraola , M. García-Lorenzo , F. Lordan-Gomis , F. Rossi , E. Prieto-Araujo , R. M. Badia

High-performance computing (HPC) is reshaping computational drug discovery by enabling large-scale, time-efficient molecular simulations. In this work, we explore HPC-driven pipelines for Alzheimer's disease drug discovery, focusing on…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-03 Paul Ruiz Alliata , Diana Rubaga , Daniel Kumlin , Alberto Puliga

The paper deals with the developing of the methodological backgrounds for the modeling and simulation of complex dynamical objects. Such backgrounds allow us to perform coordinate transformation and formulate the algorithm of its usage for…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-08-07 Roman Voliansky , Andri Pranolo

The goal of this paper is to assess the utility of Reduced-Order Models (ROMs) developed from 3D physics-based models for predicting transient thermal power output for an enhanced geothermal reservoir while explicitly accounting for…

Computational Engineering, Finance, and Science · Computer Science 2018-06-18 M. K. Mudunuru , S. Karra , D. R. Harp , G. D. Guthrie , H. S. Viswanathan

This study concerns the development of a data-based compact model for the prediction of the fluid temperature evolution in district heating (DH) pipeline networks. This so-called "reduced-order model" (ROM) is obtained from reduction of the…

Numerical Analysis · Mathematics 2022-11-28 Mengting Jiang , Michel Speetjens , Camilo Rindt , David Smeulders

This work investigates the use of digital twins for dynamical system modeling and control, integrating physics-based, data-driven, and hybrid approaches with both traditional and AI-driven controllers. Using a miniature greenhouse as a test…

Artificial Intelligence · Computer Science 2025-10-29 Adil Rasheed , Oscar Ravik , Omer San

In the early stages of aerospace design, reduced order models (ROMs) are crucial for minimizing computational costs associated with using physics-rich field information in many-query scenarios requiring multiple evaluations. The intricacy…

Machine Learning · Computer Science 2024-02-28 Bilal Mufti , Christian Perron , Dimitri N. Mavris

The numerical treatment of fluid-particle systems is a very challenging problem because of the complex coupling phenomena occurring between the two phases. Although accurate mathematical modelling is available to address this kind of…

Numerical Analysis · Mathematics 2024-03-22 Arash Hajisharifi , Rahul Halder , Michele Girfoglio , Andrea Beccari , Domenico Bonanni , Gianluigi Rozza

Orthogonal projection-based reduced order models (PROM) are the output of widely-used model reduction methods. In this work, a novel product form is derived for the reduction error system of these reduced models, and it is shown that any…

Systems and Control · Electrical Eng. & Systems 2022-01-03 Noam Leiter , Daniel Zelazo

We develop an on-the-fly reduced-order model (ROM) integrated with a flow simulation, gradually replacing a corresponding full-order model (FOM) of a physics solver. Unlike offline methods requiring a separate FOM-only simulation prior to…

Fluid Dynamics · Physics 2023-12-01 Seung Won Suh , Seung Whan Chung , Peer-Timo Bremer , Youngsoo Choi

In recent years, numerical methods in industrial applications have evolved from a pure predictive tool towards a means for optimization and control. Since standard numerical analysis methods have become prohibitively costly in such…

Computational Physics · Physics 2021-04-23 Artūrs Bērziņš , Jan Helmig , Fabian Key , Stefanie Elgeti

The Model Order Reduction (MOR) technique can provide compact numerical models for fast simulation. Different from the intrusive MOR methods, the non-intrusive MOR does not require access to the Full Order Models (FOMs), especially system…

Machine Learning · Computer Science 2022-04-20 Qinyu Zhuang , Dirk Hartmann , Hans Joachim Bungartz , Juan Manuel Lorenzi

Molecular dynamics (MD) simulations are widely used to study large-scale molecular systems. HPC systems are ideal platforms to run these studies, however, reaching the necessary simulation timescale to detect rare processes is challenging,…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-08-22 Tu Mai Anh Do , Loïc Pottier , Rafael Ferreira da Silva , Frédéric Suter , Silvina Caíno-Lores , Michela Taufer , Ewa Deelman

Reducing the computational time required by high-fidelity, full order models (FOMs) for the solution of problems in cardiac mechanics is crucial to allow the translation of patient-specific simulations into clinical practice. While FOMs,…

Numerical Analysis · Mathematics 2022-02-09 Ludovica Cicci , Stefania Fresca , Andrea Manzoni , Alfio Quarteroni