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Super-resolution ultrasound (SRUS) imaging through localising and tracking sparse microbubbles has been shown to reveal microvascular structure and flow beyond the wave diffraction limit. Most SRUS studies use standard delay and sum (DAS)…

Super-resolution ultrasound (SRUS) technology has overcome the resolution limitations of conventional ultrasound, enabling micrometer-scale imaging of microvasculature. However, due to the nature of imaging principles, three-dimensional…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Jincao Yao , Ke Zhang , Yahan Zhou , Jiafei Shen , Jie Liu , Mudassar Ali , Bojian Feng , Jiye Chen , Jinlong Fan , Ping Liang , Dong Xu

Super-Resolution Ultrasound (SRUS) imaging through localising and tracking microbubbles, also known as Ultrasound Localisation Microscopy (ULM), has demonstrated significant potential for reconstructing microvasculature and flows with…

Image and Video Processing · Electrical Eng. & Systems 2025-03-26 Jipeng Yan , Qingyuan Tan , Shusei Kawara , Jingwen Zhu , Bingxue Wang , Matthieu Toulemonde , Honghai Liu , Ying Tan , Meng-Xing Tang

Super-Resolution Ultrasound (SRUS) through localizing spatially isolated microbubbles has been demonstrated to overcome the wave diffraction limit and reveal the microvascular structure and flow information at the microscopic scale.…

Signal Processing · Electrical Eng. & Systems 2022-06-09 B. Wang , K. Riemer , M. Toulemonde , J. Yan , X. Zhou , M. Tang

Micro-vascular flow in the myocardium is of significant importance clinically but remains poorly understood. Up to 25% of patients with symptoms of coronary heart diseases have no obstructive coronary arteries and have suspected…

Super-resolution ultrasound imaging (SRUS) is an active area of research as it brings up to a ten-fold improvement in the resolution of microvascular structures. The limitations to the clinical adoption of SRUS include long acquisition…

Image and Video Processing · Electrical Eng. & Systems 2024-08-05 Arthur David Redfern , Katherine G. Brown

Ultrasound Localization Microscopy (ULM) has recently enabled the mapping of the cerebral vasculature in vivo with a resolution ten times smaller than the wavelength used, down to ten microns. However, with frame rates up to 20.000 frames…

Medical Physics · Physics 2023-10-23 Erwan Hardy , Jonathan Poree , Hatim Belgharbi , Chloe Bourquin , Frederic Lesage , Jean Provost

Generation of super-resolution (SR) ultrasound (US) images, created from the successive local-ization of individual microbubbles in the circulation, has enabled the visualization of microvascular structure and flow at a level of detail that…

Image and Video Processing · Electrical Eng. & Systems 2024-06-19 Scott Schoen , Zhigen Zhao , Ashley Alva , Chengwu Huang , Shigao Chen , Costas Arvanitis

High resolution transcranial ultrasound imaging in humans has been a persistent challenge for ultrasound due to the imaging degradation effects from aberration and reverberation. These mechanisms depend strongly on skull morphology and they…

Medical Physics · Physics 2018-11-28 Danai E. Soulioti , David Espíndola , Paul A. Dayton , Gianmarco Pinton

The purpose of this study is to enable in-vivo three-dimensional (3-D) ultrasound localization microscopy (ULM) of posterior ocular microvasculature using a 256-channel system and a 1024-element matrix array, and to overcome limitations of…

The first choice in diagnostic imaging for patients suffering from peripheral arterial disease is 2D ultrasound (US). However, for a proper imaging process, a skilled and experienced sonographer is required. Additionally, it is a highly…

Ultrasound super-localization microscopy techniques presented in the last few years enable non-invasive imaging of vascular structures at the capillary level by tracking the flow of ultrasound contrast agents (gas microbubbles). However,…

Tissues and Organs · Quantitative Biology 2016-08-10 Avinoam Bar-Zion , Charles Tremblay-Darveau , Oren Solomon , Dan Adam , Yonina C. Eldar

Super-resolution ultrasound imaging relies on the sub-wavelength localization of microbubble contrast agents. By tracking individual microbubbles, the velocity and flow within microvessels can be estimated. However, a 2D super-resolution…

Simulation-guided transcranial focused ultrasound therapies rely on estimating skull acoustic properties from pretreatment imaging. Typical clinical resolution (0.5 mm isotropic) cannot resolve bone microstructure, making the acoustic…

Medical Physics · Physics 2025-12-11 Samuel Clinard , Taylor Webb , Henrik Odéen , Dennis L. Parker , Douglas A. Christensen

Transient brain-wide neuroimaging on a microscopic scale is pivotal for brain research, yet current modalities face challenges in meeting such spatiotemporal requirements. Functional ultrasound (fUS) enables transient neurovascular imaging…

Medical Physics · Physics 2025-12-09 Yang Cai , Shaoyuan Yan , Long Xu , Yanfeng Zhu , Bo Li , Kailiang Xu

High frame rate 3-D ultrasound imaging technology combined with super-resolution processing method can visualize 3-D microvascular structures by overcoming the diffraction limited resolution in every spatial direction. However, 3-D…

Ultrasound computed tomography (USCT) is an emerging imaging modality for breast imaging that can produce quantitative images that depict the acoustic properties of tissues. Computer-simulation studies, also known as virtual imaging trials,…

Medical Physics · Physics 2022-06-24 Fu Li , Umberto Villa , Seonyeong Park , Mark A. Anastasio

Femoral artery access is essential for numerous clinical procedures, including diagnostic angiography, therapeutic catheterization, and emergency interventions. Despite its critical role, successful vascular access remains challenging due…

Robotics · Computer Science 2025-08-15 Lidia Al-Zogbi , Deepak Raina , Vinciya Pandian , Thorsten Fleiter , Axel Krieger

Ultrasound localization microscopy offers new radiation-free diagnostic tools for vascular imaging deep within the tissue. Sequential localization of echoes returned from inert microbubbles with low-concentration within the bloodstream…

Medical Physics · Physics 2018-04-11 Oren Solomon , Ruud J. G. van Sloun , Hessel Wijkstra , Massimo Mischi , Yonina C. Eldar

Significance: Optical imaging of blood oxygenation (sO$_2$) can be achieved based on the differential absorption spectra of oxy- and deoxy-haemoglobin. A key challenge in realising clinical validation of the sO$_2$ biomarkers is the absence…

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