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Although cancer is known to be characterized by several unifying biological hallmarks, systems biology has had limited success in identifying molecular signatures present in in all types of cancer. The current availability of rich data sets…

Rapid technological advances have allowed for molecular profiling across multiple omics domains from a single sample for clinical decision making in many diseases, especially cancer. As tumor development and progression are dynamic…

Methodology · Statistics 2022-02-11 Dongyan Yan , Subharup Guha

With the advance of imaging technology, digital pathology imaging of tumor tissue slides is becoming a routine clinical procedure for cancer diagnosis. This process produces massive imaging data that capture histological details in high…

Methodology · Statistics 2020-12-10 Qiwei Li , Xinlei Wang , Faming Liang , Guanghua Xiao

Early cancer detection remains one of the most critical challenges in modern healthcare, where delayed diagnosis significantly reduces survival outcomes. Recent advancements in artificial intelligence, particularly deep learning, have…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Emmanuella Avwerosuoghene Oghenekaro

Medical imaging technologies have undergone extensive development, enabling non-invasive visualization of clinical information. The traditional review of medical images by clinicians remains subjective, time-consuming, and prone to human…

Image and Video Processing · Electrical Eng. & Systems 2024-07-22 Elizaveta Lavrova , Henry C. Woodruff , Hamza Khan , Eric Salmon , Philippe Lambin , Christophe Phillips

Progress in our knowledge of tumor mechanisms and complexity led to the understanding of the physical parameters of cancer cells and their microenvironment, including the mechanical, thermal, and electrical properties, solid stress, and…

Recent advances in quantitative phase imaging (QPI) and artificial intelligence (AI) have opened up the possibility of an exciting frontier. The fast and label-free nature of QPI enables the rapid generation of large-scale and…

Computer Vision and Pattern Recognition · Computer Science 2018-07-16 YoungJu Jo , Hyungjoo Cho , Sang Yun Lee , Gunho Choi , Geon Kim , Hyun-seok Min , YongKeun Park

Cancer is a complex disease that provides various types of information depending on the scale of observation. While most tumor diagnostics are performed by observing histopathological slides, radiology images should yield additional…

Image and Video Processing · Electrical Eng. & Systems 2020-10-07 Marvin Lerousseau , Eric Deutsh , Nikos Paragios

Advances in data collection in radiation therapy have led to an abundance of opportunities for applying data mining and machine learning techniques to promote new data-driven insights. In light of these advances, supporting collaboration…

Human-Computer Interaction · Computer Science 2020-10-22 Andrew Wentzel , Guadalupe Canahuate , Lisanne van Dijk , Abdallah Mohamed , Clifton David Fuller , G. Elisabeta Marai

Purpose: Tumor-associated vasculature differs from healthy blood vessels by its chaotic architecture and twistedness, which promotes treatment resistance. Measurable differences in these attributes may help stratify patients by likely…

Medical imaging is a critical initial tool used by clinicians to determine a patient's cancer diagnosis, allowing for faster intervention and more reliable patient prognosis. At subsequent stages of patient diagnosis, genetic information is…

Computer Vision and Pattern Recognition · Computer Science 2025-12-03 Rahul Mehta

Personalized treatment of patients based on tissue-specific cancer subtypes has strongly increased the efficacy of the chosen therapies. Even though the amount of data measured for cancer patients has increased over the last years, most…

Machine Learning · Statistics 2017-09-18 Nora K. Speicher , Nico Pfeifer

Current analysis of tumor proliferation, the most salient prognostic biomarker for invasive breast cancer, is limited to subjective mitosis counting by pathologists in localized regions of tissue images. This study presents the first…

Computer Vision and Pattern Recognition · Computer Science 2016-10-12 Manan Shah , Christopher Rubadue , David Suster , Dayong Wang

Medical image classification is a critical task in healthcare, enabling accurate and timely diagnosis. However, deploying deep learning models on resource-constrained edge devices presents significant challenges due to computational and…

Image and Video Processing · Electrical Eng. & Systems 2025-12-30 Mahsa Lavaei , Zahra Abadi , Salar Beigzad , Alireza Maleki

Magnetic resonance imaging (MRI) offers superior soft tissue contrast and is widely used in biomedicine. However, conventional MRI is not quantitative, which presents a bottleneck in image analysis and digital healthcare. Typically,…

The distribution and appearance of nuclei are essential markers for the diagnosis and study of cancer. Despite the importance of nuclear morphology, there is a lack of large scale, accurate, publicly accessible nucleus segmentation data. To…

Image and Video Processing · Electrical Eng. & Systems 2020-12-02 Le Hou , Rajarsi Gupta , John S. Van Arnam , Yuwei Zhang , Kaustubh Sivalenka , Dimitris Samaras , Tahsin M. Kurc , Joel H. Saltz

Tumor shape is a key factor that affects tumor growth and metastasis. This paper proposes a topological feature computed by persistent homology to characterize tumor progression from digital pathology and radiology images and examines its…

Computer Vision and Pattern Recognition · Computer Science 2023-03-01 Chul Moon , Qiwei Li , Guanghua Xiao

Medical imaging is widely used in cancer diagnosis and treatment, and artificial intelligence (AI) has achieved tremendous success in various tasks of medical image analysis. This paper reviews AI-based tumor subregion analysis in medical…

Image and Video Processing · Electrical Eng. & Systems 2021-03-26 Mingquan Lin , Jacob Wynne , Yang Lei , Tonghe Wang , Walter J. Curran , Tian Liu , Xiaofeng Yang

Assessing the quality of cancer care administered by US health providers poses numerous challenges due to meaningful heterogeneity in patient populations. Patients undergoing oncology treatment exhibit substantial variation in disease…

Applications · Statistics 2025-02-17 Yige Li , Nancy L. Keating , Mary Beth Landrum , Jose R. Zubizarreta

Brain tumors require an assessment to ensure timely diagnosis and effective patient treatment. Morphological factors such as size, location, texture, and variable appearance complicate tumor inspection. Medical imaging presents challenges,…

Computer Vision and Pattern Recognition · Computer Science 2025-06-27 Md. Zahid Hasan , Abdullah Tamim , D. M. Asadujjaman , Md. Mahfujur Rahman , Md. Abu Ahnaf Mollick , Nosin Anjum Dristi , Abdullah-Al-Noman
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