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Physicians considering clinical trials for their patients are met with the laborious process of checking many text based eligibility criteria. Large Language Models (LLMs) have shown to perform well for clinical information extraction and…

Machine Learning · Computer Science 2023-06-30 Danny M. den Hamer , Perry Schoor , Tobias B. Polak , Daniel Kapitan

Backgrounds: Information extraction (IE) is critical in clinical natural language processing (NLP). While large language models (LLMs) excel on generative tasks, their performance on extractive tasks remains debated. Methods: We…

Trustworthiness in healthcare question-answering (QA) systems is important for ensuring patient safety, clinical effectiveness, and user confidence. As large language models (LLMs) become increasingly integrated into medical settings, the…

Computation and Language · Computer Science 2025-11-04 Yinuo Wang , Baiyang Wang , Robert E. Mercer , Frank Rudzicz , Sudipta Singha Roy , Pengjie Ren , Zhumin Chen , Xindi Wang

Clinical trials are central to evidence-based medicine, yet many struggle to meet enrollment targets, despite the availability of over half a million trials listed on ClinicalTrials.gov, which attracts approximately two million users…

Computation and Language · Computer Science 2026-04-13 Cyrus Zhou , Yufei Jin , Yilin Xu , Yu-Chiang Wang , Chieh-Ju Chao , Monica S. Lam

The current generation of large language models (LLMs) is typically designed for broad, general-purpose applications, while domain-specific LLMs, especially in vertical fields like medicine, remain relatively scarce. In particular, the…

Evaluating large language models (LLMs) in medicine is crucial because medical applications require high accuracy with little room for error. Current medical benchmarks have three main types: medical exam-based, comprehensive medical, and…

The rapid advancement of large language models (LLMs) has highlighted the need for robust evaluation frameworks that assess their core capabilities, such as reasoning, knowledge, and commonsense, leading to the inception of certain…

Computation and Language · Computer Science 2024-10-10 Dahyun Kim , Sukyung Lee , Yungi Kim , Attapol Rutherford , Chanjun Park

Documentation burden is a major contributor to clinician burnout, which is rising nationally and is an urgent threat to our ability to care for patients. Artificial intelligence (AI) chatbots, such as ChatGPT, could reduce clinician burden…

Language modelling provides a step towards intelligent communication systems by harnessing large repositories of written human knowledge to better predict and understand the world. In this paper, we present an analysis of Transformer-based…

Clinician notes are a rich source of patient information but often contain inconsistencies due to varied writing styles, colloquialisms, abbreviations, medical jargon, grammatical errors, and non-standard formatting. These inconsistencies…

Computation and Language · Computer Science 2025-01-03 Daniel B. Hier , Michael D. Carrithers , Thanh Son Do , Tayo Obafemi-Ajayi

Large Language Models (LLMs) face significant challenges in distributed healthcare, including consolidating specialized domain knowledge across institutions while maintaining privacy, reducing computational overhead, and preventing…

Machine Learning · Computer Science 2025-11-18 Prakrit Timilsina , Anuj Nepal , Rajan Kadel , Robin Doss

Generative AI-powered by Large Language Models (LLMs)-is increasingly deployed in industry across healthcare decision support, financial analytics, enterprise retrieval, and conversational automation, where reliability, efficiency, and cost…

Computation and Language · Computer Science 2026-04-22 Abdullah Mohammad , Sushant Kumar Ray , Pushkar Arora , Rafiq Ali , Ebad Shabbir , Gautam Siddharth Kashyap , Jiechao Gao , Usman Naseem

Language models have become increasingly popular in recent years for tasks like information retrieval. As use-cases become oriented toward specific domains, fine-tuning becomes default for standard performance. To fine-tune these models for…

Computation and Language · Computer Science 2023-01-02 Pranjali Awasthi , David Recio-Mitter , Yosuke Kyle Sugi

Test-time scaling has emerged as a powerful technique for enhancing the reasoning capabilities of large language models. However, its effectiveness in medical reasoning remains uncertain, as the medical domain fundamentally differs from…

Computation and Language · Computer Science 2026-02-19 Xiaoke Huang , Juncheng Wu , Hui Liu , Xianfeng Tang , Yuyin Zhou

Large language models have exhibited exceptional performance on various Natural Language Processing (NLP) tasks, leveraging techniques such as the pre-training, and instruction fine-tuning. Despite these advances, their effectiveness in…

Computation and Language · Computer Science 2023-06-19 Guangyu Wang , Guoxing Yang , Zongxin Du , Longjun Fan , Xiaohu Li

Language models (LMs) have demonstrated expert-level reasoning and recall abilities in medicine. However, computational costs and privacy concerns are mounting barriers to wide-scale implementation. To address these significant limitations,…

Computation and Language · Computer Science 2025-12-01 Krithik Vishwanath , Jaden Stryker , Anton Alyakin , Daniel Alexander Alber , Eric Karl Oermann

We introduce the Yi model family, a series of language and multimodal models that demonstrate strong multi-dimensional capabilities. The Yi model family is based on 6B and 34B pretrained language models, then we extend them to chat models,…

The rapid growth of biomedical literature poses challenges for manual knowledge curation and synthesis. Biomedical Natural Language Processing (BioNLP) automates the process. While Large Language Models (LLMs) have shown promise in general…

Text-to-SQL is a key natural language processing task that maps natural language questions to SQL queries, enabling intuitive interaction with web-based databases. Although current methods perform well on benchmarks like BIRD and Spider,…

Computation and Language · Computer Science 2026-02-06 Tao Liu , Jiafan Lu , Bohan Yu , Pengcheng Wu , Liu Haixin , Guoyu Xu , Li Xiangheng , Lixiao Li , Jiaming Hou , Zhao Shijun , Xinglin Lyu , Kunli Zhang , Yuxiang Jia , Hongyin Zan

Large language models (LLMs) demonstrate strong mathematical reasoning, but reliance on closed-source APIs for OR tasks raises privacy concerns, and training open-source models from scratch incurs high compute costs. We introduce…

Artificial Intelligence · Computer Science 2025-10-03 Jianzhang Zhang , Jialong Zhou , Chuang Liu