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Nowadays, the screening methods for the early detection of lung cancer struggle with several limitations such as many false positive results and low sensitivity. The detection of specific biomarkers is of high interest to complement these…

Quantitative Methods · Quantitative Biology 2021-02-19 Juul Goossens , Jente Gieghase , Elien Derveaux , Peter Adriaensens

Understanding the functional architecture of the brain in terms of networks is becoming increasingly common. In most fMRI applications functional networks are assumed to be stationary, resulting in a single network estimated for the entire…

Alzheimer's disease is the most common neurodegenerative disease. The aim of this study is to infer structural changes in brain connectivity resulting from disease progression using cortical thickness measurements from a cohort of…

Understanding the dynamic reorganization of brain networks is critical for predicting cognitive decline, neurological progression, and individual variability in clinical outcomes. This work proposes a multimodal graph neural network…

Machine Learning · Computer Science 2026-02-11 Preksha Girish , Rachana Mysore , Kiran K. N. , Hiranmayee R. , Shipra Prashanth , Shrey Kumar

Major depressive disorder (MDD) requires study of brain functional connectivity alterations for patients, which can be uncovered by resting-state functional magnetic resonance imaging (rs-fMRI) data. We consider the problem of identifying…

Machine Learning · Statistics 2022-06-10 Shuai Liu , Yixuan Qiu , Baojuan Li , Huaning Wang , Xiangyu Chang

The graphical Lasso (GLASSO) is a widely used algorithm for learning high-dimensional undirected Gaussian graphical models (GGM). Given i.i.d. observations from a multivariate normal distribution, GLASSO estimates the precision matrix by…

Methodology · Statistics 2026-01-15 Ha Nguyen , Sumanta Basu

Recently, there has been increased interest in fusing multimodal imaging to better understand brain organization. Specifically, accounting for knowledge of anatomical pathways connecting brain regions should lead to desirable outcomes such…

Applications · Statistics 2018-03-02 Ixavier A. Higgins , Suprateek Kundu , Ying Guo

Smoking continues to be a major preventable cause of death worldwide, affecting millions through damage to the heart, metabolism, liver, and kidneys. However, current medical screening methods often miss the early warning signs of…

Machine Learning · Computer Science 2026-01-27 Vaskar Chakma , MD Jaheid Hasan Nerab , Abdur Rouf , Abu Sayed , Hossem MD Saim , Md. Nournabi Khan

Graphical models have been used extensively for modeling brain connectivity networks. However, unmeasured confounders and correlations among measurements are often overlooked during model fitting, which may lead to spurious scientific…

Methodology · Statistics 2020-12-10 Yanxin Jin , Yang Ning , Kean Ming Tan

Several studies have used structural correlation networks, derived from anatomical covariance of brain regions, to analyze neurologic changes associated with multiple sclerosis, schizophrenia and breast cancer [1][2]. Graph-theoretical…

Quantitative Methods · Quantitative Biology 2019-04-25 Muhammad Usman Sadiq , Diana Svaldi , Trey Shenk , Evan Breedlove , Victoria Poole , Greg Tamer , Kausar Abbas , Thomas Talavage

Dynamical effects on healthy brains and brains affected by tumor are investigated via numerical simulations. The brains are modeled as multilayer networks consisting of neuronal oscillators, whose connectivities are extracted from Magnetic…

Adaptation and Self-Organizing Systems · Physics 2021-02-03 I. Koulierakis , D. A. Verganelakis , I. Omelchenko , A. Zakharova , E. Schoell , A. Provata

Resting-state functional magnetic resonance imaging (rs-fMRI) is a noninvasive technique pivotal for understanding human neural mechanisms of intricate cognitive processes. Most rs-fMRI studies compute a single static functional…

Neurons and Cognition · Quantitative Biology 2025-02-25 Bishal Thapaliya , Robyn Miller , Jiayu Chen , Yu-Ping Wang , Esra Akbas , Ram Sapkota , Bhaskar Ray , Pranav Suresh , Santosh Ghimire , Vince Calhoun , Jingyu Liu

Flexible laryngoscopy is commonly performed by otolaryngologists to detect laryngeal diseases and to recognize potentially malignant lesions. Recently, researchers have introduced machine learning techniques to facilitate automated…

Computer Vision and Pattern Recognition · Computer Science 2023-05-29 Tianxiao Zhang , Andrés M. Bur , Shannon Kraft , Hannah Kavookjian , Bryan Renslo , Xiangyu Chen , Bo Luo , Guanghui Wang

Brain networks has attracted the interests of many neuroscientists. From functional MRI (fMRI) data, statistical tools have been developed to recover brain networks. However, the dimensionality of whole-brain fMRI, usually in hundreds of…

Methodology · Statistics 2014-04-08 Xi Luo

Spontaneous brain activity, as observed in functional neuroimaging, has been shown to display reproducible structure that expresses brain architecture and carries markers of brain pathologies. An important view of modern neuroscience is…

Machine Learning · Statistics 2010-11-15 Gaël Varoquaux , Alexandre Gramfort , Jean Baptiste Poline , Bertrand Thirion

Alzheimer's disease (AD) is characterized by a sequence of pathological changes, which are commonly assessed in vivo using MRI and PET. Currently, the most approaches to analyze statistical associations between brain regions rely on Pearson…

Neurons and Cognition · Quantitative Biology 2020-03-30 Martin Dyrba , Reza Mohammadi , Michel J. Grothe , Thomas Kirste , Stefan J. Teipel

Modern neuroimaging technologies, combined with state-of-the-art data processing pipelines, have made it possible to collect longitudinal observations of an individual's brain connectome at different ages. It is of substantial scientific…

Applications · Statistics 2019-08-16 Lu Wang , Zhengwu Zhang

Exploring the complex structure of the human brain is crucial for understanding its functionality and diagnosing brain disorders. Thanks to advancements in neuroimaging technology, a novel approach has emerged that involves modeling the…

Machine Learning · Computer Science 2024-06-06 Xuexiong Luo , Jia Wu , Jian Yang , Shan Xue , Amin Beheshti , Quan Z. Sheng , David McAlpine , Paul Sowman , Alexis Giral , Philip S. Yu

Recent advances in molecular and genetic research have identified a diverse range of brain tumor sub-types, shedding light on differences in their molecular mechanisms, heterogeneity, and origins. The present study performs whole-brain…

Neurons and Cognition · Quantitative Biology 2024-07-26 Debanjali Bhattacharya , Ninad Aithal , Manish Jayswal , Neelam Sinha

With the wide adoption of functional magnetic resonance imaging (fMRI) by cognitive neuroscience researchers, large volumes of brain imaging data have been accumulated in recent years. Aggregating these data to derive scientific insights…

Applications · Statistics 2020-06-01 Ming Bo Cai , Michael Shvartsman , Anqi Wu , Hejia Zhang , Xia Zhu