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Despite significant advances in artificial intelligence (AI) for computer vision, its application in medical imaging has been limited by the burden and limits of expert-generated labels. We used images from optical coherence tomography…

Computer Vision and Pattern Recognition · Computer Science 2018-02-27 Cecilia S. Lee , Ariel J. Tyring , Yue Wu , Sa Xiao , Ariel S. Rokem , Nicolaas P. Deruyter , Qinqin Zhang , Adnan Tufail , Ruikang K. Wang , Aaron Y. Lee

Segmentation of indicated targets aids in the precise analysis of optical coherence tomography angiography (OCTA) samples. Existing segmentation methods typically perform on 2D projection targets, making it challenging to capture the…

Computer Vision and Pattern Recognition · Computer Science 2024-09-17 Xinrun Chen , Chengliang Wang , Haojian Ning , Mengzhan Zhang , Mei Shen , Shiying Li

Optical coherence tomography angiography (OCTA) is a novel imaging modality that has been widely utilized in ophthalmology and neuroscience studies to observe retinal vessels and microvascular systems. However, publicly available OCTA…

Image and Video Processing · Electrical Eng. & Systems 2022-12-27 Mingchao Li , Kun Huang , Qiuzhuo Xu , Jiadong Yang , Yuhan Zhang , Zexuan Ji , Keren Xie , Songtao Yuan , Qinghuai Liu , Qiang Chen

Segmenting specific targets or structures in optical coherence tomography angiography (OCTA) images is fundamental for conducting further pathological studies. The retinal vascular layers are rich and intricate, and such vascular with…

Image and Video Processing · Electrical Eng. & Systems 2024-04-30 Xinrun Chen , Mei Shen , Haojian Ning , Mengzhan Zhang , Chengliang Wang , Shiying Li

Purpose: We proposed a deep convolutional neural network (CNN), named Retinal Fluid Segmentation Network (ReF-Net) to segment volumetric retinal fluid on optical coherence tomography (OCT) volume. Methods: 3 x 3-mm OCT scans were acquired…

Image and Video Processing · Electrical Eng. & Systems 2020-10-28 Yukun Guo , Tristan T. Hormel , Honglian Xiong , Jie Wang , Thomas S. Hwang , Yali Jia

Retinal neovascularization (RNV) is a vision threatening development in diabetic retinopathy (DR). Vision loss associated with RNV is preventable with timely intervention, making RNV clinical screening and monitoring a priority. Optical…

Image and Video Processing · Electrical Eng. & Systems 2026-04-01 Jinyi Hao , Jie Wang , Liqin Gao , Tristan T. Hormel , Yukun Guo , An-Lun Wu , Christina J. Flaxel , Steven T. Bailey , Kotaro Tsuboi , Thomas S. Hwang , Yali Jia

Optical coherence tomography angiography (OCTA) shows its great importance in imaging microvascular networks by providing accurate 3D imaging of blood vessels, but it relies upon specialized sensors and expensive devices. For this reason,…

Computer Vision and Pattern Recognition · Computer Science 2025-04-03 Zhuangzhuang Chen , Hualiang Wang , Chubin Ou , Xiaomeng Li

Recent studies suggest that early stages of diabetic retinopathy (DR) can be diagnosed by monitoring vascular changes in the deep vascular complex. In this work, we investigate a novel method for automated DR grading based on optical…

Image and Video Processing · Electrical Eng. & Systems 2022-12-22 Linus Kreitner , Ivan Ezhov , Daniel Rueckert , Johannes C. Paetzold , Martin J. Menten

Age-related macular degeneration (AMD) is characterized by early micro-vascular alterations that can be captured non-invasively using optical coherence tomography angiography (OCTA), yet most deep learning (DL) models rely on global…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Margalit G. Mitzner , Moinak Bhattacharya , Zhilin Zou , Chao Chen , Prateek Prasanna

Handheld Optical Coherence Tomography Angiography (OCTA) enables noninvasive retinal imaging in uncooperative or pediatric subjects, but is highly susceptible to motion artifacts that severely degrade volumetric image quality. Sudden motion…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Nick DiSanto , Ehsan Khodapanah Aghdam , Han Liu , Jacob Watson , Yuankai K. Tao , Hao Li , Ipek Oguz

Eye diseases are common in older Americans and can lead to decreased vision and blindness. Recent advancements in imaging technologies allow clinicians to capture high-quality images of the retinal blood vessels via Optical Coherence…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Jacob Thrasher , Annahita Amireskandari , Prashnna Gyawali

At the present time Optical Coherence Tomography (OCT) is among the most commonly used non-invasive imaging methods for the acquisition of large volumetric scans of human retinal tissues and vasculature. To resolve decisive information from…

Computer Vision and Pattern Recognition · Computer Science 2021-11-02 D. Sitenko , B. Boll , C. Schnörr

Optical Coherence Tomography Angiography (OCTA) has been increasingly used in the management of eye and systemic diseases in recent years. Manual or automatic analysis of blood vessel in 2D OCTA images (en face angiograms) is commonly used…

Image and Video Processing · Electrical Eng. & Systems 2021-03-01 Shuai Yu , Jianyang Xie , Jinkui Hao , Yalin Zheng , Jiong Zhang , Yan Hu , Jiang Liu , Yitian Zhao

Automated detection of retinal structures, such as retinal vessels (RV), the foveal avascular zone (FAZ), and retinal vascular junctions (RVJ), are of great importance for understanding diseases of the eye and clinical decision-making. In…

Image and Video Processing · Electrical Eng. & Systems 2022-08-24 Jinkui Hao , Ting Shen , Xueli Zhu , Yonghuai Liu , Ardhendu Behera , Dan Zhang , Bang Chen , Jiang Liu , Jiong Zhang , Yitian Zhao

Optical coherence tomography angiography (OCTA) provides non-invasive visualization of retinal microvasculature, but learning robust representations remains challenging due to sparse vessel structures and strong topological constraints.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Ilerioluwakiiye Abolade , Prince Mireku , Kelechi Chibundu , Peace Ododo , Emmanuel Idoko , Promise Omoigui , Solomon Odelola

Optical coherence tomography (OCT) helps ophthalmologists assess macular edema, accumulation of fluids, and lesions at microscopic resolution. Quantification of retinal fluids is necessary for OCT-guided treatment management, which relies…

Image and Video Processing · Electrical Eng. & Systems 2022-12-15 Reza Rasti , Armin Biglari , Mohammad Rezapourian , Ziyun Yang , Sina Farsiu

Accurate segmentation of 3D vascular structures is essential for various medical imaging applications. The dispersed nature of vascular structures leads to inherent spatial uncertainty and necessitates location awareness, yet most current…

Image and Video Processing · Electrical Eng. & Systems 2026-04-30 Gen Shi , Hui Zhang , Jie Tian

The lack of efficient segmentation methods and fully-labeled datasets limits the comprehensive assessment of optical coherence tomography angiography (OCTA) microstructures like retinal vessel network (RVN) and foveal avascular zone (FAZ),…

Image and Video Processing · Electrical Eng. & Systems 2026-02-04 Peng Xiao , Xiaodong Hu , Ke Ma , Gengyuan Wang , Ziqing Feng , Yuancong Huang , Jin Yuan

Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA) are key diagnostic tools for clinical evaluation and management of retinal diseases. Compared to traditional OCT, OCTA provides richer microvascular…

Image and Video Processing · Electrical Eng. & Systems 2025-04-01 Renzhi Tian , Jinjie Wang , Wei Yang , Weizhen Li , Haoran Chen , Yiran Zhu , Chengchang Pan , Honggang Qi

Optical coherence tomography angiography (OCTA) has been established as a powerful tool for investigating vascular diseases and is expected to become a standard of care technology. However, its widespread clinical usage is hindered by…

Medical Physics · Physics 2021-09-10 Si Chen , Kan Lin , Linbo Liu