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Magnetic resonance imaging (MRI)-based synthetic computed tomography (sCT) simplifies radiation therapy treatment planning by eliminating the need for CT simulation and error-prone image registration, ultimately reducing patient radiation…

Image and Video Processing · Electrical Eng. & Systems 2023-06-01 Shaoyan Pan , Elham Abouei , Jacob Wynne , Tonghe Wang , Richard L. J. Qiu , Yuheng Li , Chih-Wei Chang , Junbo Peng , Justin Roper , Pretesh Patel , David S. Yu , Hui Mao , Xiaofeng Yang

Attenuation correction is an essential requirement of positron emission tomography (PET) image reconstruction to allow for accurate quantification. However, attenuation correction is particularly challenging for PET-MRI as neither PET nor…

Deep learning techniques, particularly convolutional neural networks (CNNs), have gained traction for synthetic computed tomography (sCT) generation from Magnetic resonance imaging (MRI), Cone-beam computed tomography (CBCT) and PET. In…

Image and Video Processing · Electrical Eng. & Systems 2023-08-29 Satoshi Kondo , Satoshi Kasai , Kousuke Hirasawa

Deep-learning-based MR-to-CT synthesis can estimate the electron density of tissues, thereby facilitating PET attenuation correction in whole-body PET/MR imaging. However, whole-body MR-to-CT synthesis faces several challenges including the…

Image and Video Processing · Electrical Eng. & Systems 2024-11-27 Jiaxu Zheng , Zhenrong Shen , Lichi Zhang , Qun Chen

Synthesized medical images have several important applications, e.g., as an intermedium in cross-modality image registration and as supplementary training samples to boost the generalization capability of a classifier. Especially,…

Computer Vision and Pattern Recognition · Computer Science 2019-03-19 Zizhao Zhang , Lin Yang , Yefeng Zheng

Cone-Beam Computed Tomography (CBCT) is widely used for intraoperative imaging due to its rapid acquisition and low radiation dose. However, CBCT images typically suffer from artifacts and lower visual quality compared to conventional…

Image and Video Processing · Electrical Eng. & Systems 2025-07-09 Maximilian Tschuchnig , Lukas Lamminger , Philipp Steininger , Michael Gadermayr

Synthetic CT image generation from MRI scan is necessary to create radiotherapy plans without the need of co-registered MRI and CT scans. The chosen baseline adversarial model with cycle consistency permits unpaired image-to-image…

Image and Video Processing · Electrical Eng. & Systems 2023-08-16 Denis Prokopenko , Joël Valentin Stadelmann , Heinrich Schulz , Steffen Renisch , Dmitry V. Dylov

MRI provides superior soft tissue contrast without ionizing radiation; however, the absence of electron density information limits its direct use for dose calculation. As a result, current radiotherapy workflows rely on combined MRI and CT…

Computer Vision and Pattern Recognition · Computer Science 2026-02-06 Zolnamar Dorjsembe , Hung-Yi Chen , Furen Xiao , Hsing-Kuo Pao

Cone-Beam Computed Tomography (CBCT) is widely used for real-time intraoperative imaging due to its low radiation dose and high acquisition speed. However, despite its high resolution, CBCT suffers from significant artifacts and thereby…

Image and Video Processing · Electrical Eng. & Systems 2025-06-11 Maximilian Tschuchnig , Lukas Lamminger , Philipp Steininger , Michael Gadermayr

Multi-modal brain magnetic resonance imaging (MRI) plays a crucial role in clinical diagnostics by providing complementary information across different imaging modalities. However, a common challenge in clinical practice is missing MRI…

Image and Video Processing · Electrical Eng. & Systems 2025-06-04 Haowen Pang , Weiyan Guo , Chuyang Ye

Quantifying normative pediatric cranial development and suture ossification is crucial for diagnosing and treating growth-related cephalic disorders. Computed tomography (CT) is widely used to evaluate cranial and sutural deformities;…

Computer Vision and Pattern Recognition · Computer Science 2026-01-01 Krithika Iyer , Austin Tapp , Athelia Paulli , Gabrielle Dickerson , Syed Muhammad Anwar , Natasha Lepore , Marius George Linguraru

Generating synthetic CT (sCT) from MRI or CBCT plays a crucial role in enabling MRI-only and CBCT-based adaptive radiotherapy, improving treatment precision while reducing patient radiation exposure. To address this task, we adopt a fully…

Computer Vision and Pattern Recognition · Computer Science 2026-04-24 Arnela Hadzic , Simon Johannes Joham , Martin Urschler

This paper strives to generate a synthetic computed tomography (CT) image from a magnetic resonance (MR) image. The synthetic CT image is valuable for radiotherapy planning when only an MR image is available. Recent approaches have made…

Image and Video Processing · Electrical Eng. & Systems 2021-07-20 Zenglin Shi , Pascal Mettes , Guoyan Zheng , Cees Snoek

Reducing the radiation dose in computed tomography (CT) is important to mitigate radiation-induced risks. One option is to employ a well-trained model to compensate for incomplete information and map sparse-view measurements to the CT…

Image and Video Processing · Electrical Eng. & Systems 2023-03-29 Xiaoyue Li , Kai Shang , Gaoang Wang , Mark D. Butala

Radiation therapy (RT) requires precise dose delivery over multiple fractions, with CT fundamental for treatment planning due to its electron density information. Repeated CT acquisitions impose radiation exposure and logistical burdens,…

Image synthesis is used to generate synthetic CTs (sCTs) from on-treatment cone-beam CTs (CBCTs) with a view to improving image quality and enabling accurate dose computation to facilitate a CBCT-based adaptive radiotherapy workflow. As…

Image and Video Processing · Electrical Eng. & Systems 2023-12-05 Chelsea A. H. Sargeant , Edward G. A. Henderson , Dónal M. McSweeney , Aaron G. Rankin , Denis Page

Deep learning-based computer-aided diagnosis (CAD) of medical images requires large datasets. However, the lack of large publicly available labeled datasets limits the development of deep learning-based CAD systems. Generative Adversarial…

Image and Video Processing · Electrical Eng. & Systems 2025-03-04 Muhammad Rafiq , Hazrat Ali , Ghulam Mujtaba , Zubair Shah , Shoaib Azmat

Accurate targeting is critical for the effectiveness of transcranial focused ultrasound (tFUS) neuromodulation. While CT provides accurate skull acoustic properties, its ionizing radiation and poor soft tissue contrast limit clinical…

Medical Physics · Physics 2025-07-14 Hengyu Gao , Shaodong Ding , Ziyang Liu , Jiefu Zhang , Bolun Li , Zhiwu An , Li Wang , Jing Jing , Tao Liu , Yubo Fan , Zhongtao Hu

The ability to synthesise Computed Tomography images - commonly known as pseudo CT, or pCT - from MRI input data is commonly assessed using an intensity-wise similarity, such as an L2-norm between the ground truth CT and the pCT. However,…

Image and Video Processing · Electrical Eng. & Systems 2020-04-15 Kerstin Kläser , Thomas Varsavsky , Pawel Markiewicz , Tom Vercauteren , David Atkinson , Kris Thielemans , Brian Hutton , M Jorge Cardoso , Sebastien Ourselin

Model-based treatment planning for transcranial ultrasound therapy typically involves mapping the acoustic properties of the skull from an x-ray computed tomography (CT) image of the head. Here, three methods for generating pseudo-CT images…

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