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This paper presents a new regularization method to train a fully convolutional network for semantic tissue segmentation in histopathological images. This method relies on the benefit of unsupervised learning, in the form of image…

Computer Vision and Pattern Recognition · Computer Science 2020-11-26 C. T. Sari , C. Sokmensuer , C. Gunduz-Demir

This work explores the application of Federated Learning (FL) to Unsupervised Semantic image Segmentation (USS). Recent USS methods extract pixel-level features using frozen visual foundation models and refine them through self-supervised…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Evangelos Charalampakis , Vasileios Mygdalis , Ioannis Pitas

This paper presents a novel method for unsupervised segmentation of pathology images. Staging of lung cancer is a major factor of prognosis. Measuring the maximum dimensions of the invasive component in a pathology images is an essential…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 Takayasu Moriya , Holger R. Roth , Shota Nakamura , Hirohisa Oda , Kai Nagara , Masahiro Oda , Kensaku Mori

Image segmentation is crucial in many computational pathology pipelines, including accurate disease diagnosis, subtyping, outcome, and survivability prediction. The common approach for training a segmentation model relies on a pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Sachin Kumar Danisetty , Alexandros Graikos , Srikar Yellapragada , Dimitris Samaras

Deep convolutional neural networks (CNNs) have been widely used for medical image segmentation. In most studies, only the output layer is exploited to compute the final segmentation results and the hidden representations of the deep learned…

Image and Video Processing · Electrical Eng. & Systems 2022-12-20 Sheng He , Yanfang Feng , P. Ellen Grant , Yangming Ou

Fully supervised segmentation methods require a large training cohort of already segmented images, providing information at the pixel level of each image. We present a method to automatically segment and model pathologies in medical images,…

Computer Vision and Pattern Recognition · Computer Science 2019-08-22 Simon Andermatt , Antal Horváth , Simon Pezold , Philippe Cattin

The application of deep learning to medical image segmentation has been hampered due to the lack of abundant pixel-level annotated data. Few-shot Semantic Segmentation (FSS) is a promising strategy for breaking the deadlock. However, a…

Computer Vision and Pattern Recognition · Computer Science 2021-10-26 Xiaoang Shen , Guokai Zhang , Huilin Lai , Jihao Luo , Jianwei Lu , Ye Luo

Pathology image segmentation is crucial in computational pathology for analyzing histological features relevant to cancer diagnosis and prognosis. However, current methods face major challenges in clinical applications due to limited…

Computer Vision and Pattern Recognition · Computer Science 2025-08-20 Zhixuan Chen , Junlin Hou , Liqi Lin , Yihui Wang , Yequan Bie , Xi Wang , Yanning Zhou , Ronald Cheong Kin Chan , Hao Chen

Deep neural networks are powerful tools for biomedical image segmentation. These models are often trained with heavy supervision, relying on pairs of images and corresponding voxel-level labels. However, obtaining segmentations of…

Image and Video Processing · Electrical Eng. & Systems 2020-04-30 Evan M. Yu , Juan Eugenio Iglesias , Adrian V. Dalca , Mert R. Sabuncu

Supervised deep learning for semantic segmentation has achieved excellent results in accurately identifying anatomical and pathological structures in medical images. However, it often requires large annotated training datasets, which limits…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Luca Ciampi , Gabriele Lagani , Giuseppe Amato , Fabrizio Falchi

Semantic segmentation of electron microscopy (EM) images of biological samples remains a challenge in the life sciences. EM data captures details of biological structures, sometimes with such complexity that even human observers can find it…

Computer Vision and Pattern Recognition · Computer Science 2025-11-03 Sheida Rahnamai Kordasiabi , Damian Dalle Nogare , Florian Jug

This paper presents a novel unsupervised segmentation method for 3D medical images. Convolutional neural networks (CNNs) have brought significant advances in image segmentation. However, most of the recent methods rely on supervised…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 Takayasu Moriya , Holger R. Roth , Shota Nakamura , Hirohisa Oda , Kai Nagara , Masahiro Oda , Kensaku Mori

We develop a neural network architecture which, trained in an unsupervised manner as a denoising diffusion model, simultaneously learns to both generate and segment images. Learning is driven entirely by the denoising diffusion objective,…

Computer Vision and Pattern Recognition · Computer Science 2023-12-12 Xin Yuan , Michael Maire

Automated semantic segmentation of cell nuclei in microscopic images is crucial for disease diagnosis and tissue microenvironment analysis. Nonetheless, this task presents challenges due to the complexity and heterogeneity of cells. While…

Image and Video Processing · Electrical Eng. & Systems 2023-08-10 Zhuchen Shao , Sourya Sengupta , Hua Li , Mark A. Anastasio

Biomedical image segmentation plays a significant role in computer-aided diagnosis. However, existing CNN based methods rely heavily on massive manual annotations, which are very expensive and require huge human resources. In this work, we…

Computer Vision and Pattern Recognition · Computer Science 2023-01-13 Ruifei Zhang , Sishuo Liu , Yizhou Yu , Guanbin Li

In digital pathology, segmenting densely distributed objects like glands and nuclei is crucial for downstream analysis. Since detailed pixel-wise annotations are very time-consuming, we need semi-supervised segmentation methods that can…

Image and Video Processing · Electrical Eng. & Systems 2024-07-18 Meilong Xu , Xiaoling Hu , Saumya Gupta , Shahira Abousamra , Chao Chen

Medical image segmentation is vital for modern healthcare and is a key element of computer-aided diagnosis. While recent advancements in computer vision have explored unsupervised segmentation using pre-trained models, these methods have…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Mosong Ma , Tania Stathaki , Michalis Lazarou

Most state-of-the-art techniques for medical image segmentation rely on deep-learning models. These models, however, are often trained on narrowly-defined tasks in a supervised fashion, which requires expensive labeled datasets. Recent…

Image and Video Processing · Electrical Eng. & Systems 2023-10-04 Heejong Kim , Victor Ion Butoi , Adrian V. Dalca , Daniel J. A. Margolis , Mert R. Sabuncu

Automatic histopathology image segmentation is crucial to disease analysis. Limited available labeled data hinders the generalizability of trained models under the fully supervised setting. Semi-supervised learning (SSL) based on generative…

Computer Vision and Pattern Recognition · Computer Science 2020-12-18 Hongxiao Wang , Hao Zheng , Jianxu Chen , Lin Yang , Yizhe Zhang , Danny Z. Chen

Unsupervised semantic segmentation aims to achieve high-quality semantic grouping without human-labeled annotations. With the advent of self-supervised pre-training, various frameworks utilize the pre-trained features to train prediction…

Computer Vision and Pattern Recognition · Computer Science 2026-05-11 Junho Kim , Byung-Kwan Lee , Yong Man Ro
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