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The brain-skull interface (meninges) plays a critical role in governing brain motion during head impacts, yet computational models often simplify this interface using idealized contact conditions due to limited experimental data. This study…

Computational Engineering, Finance, and Science · Computer Science 2025-12-10 Sajjad Arzemanzadeh , Karol Miller , Tim Rosenow , Sjoerd B. Vos , Adam Wittek

Understanding the mechanical behavior of brain tissue is crucial for advancing both fundamental neuroscience and clinical applications. Yet, accurately measuring these properties remains challenging due to the brain unique mechanical…

Computational biomechanics of the brain for neurosurgery is an emerging area of research recently gaining in importance and practical applications. This review paper presents the contributions of the Intelligent Systems for Medicine…

Computational Engineering, Finance, and Science · Computer Science 2019-04-03 K. Miller , G. R. Joldes , G. Bourantas , S. K. Warfield , D. E. Hyde , R. Kikinis , A. Wittek

Brain tissue accommodates non-linear deformations and exhibits time-dependent mechanical behaviour. The latter is one of the most pronounced features of brain tissue, manifesting itself primarily through viscoelastic effects such as stress…

Soft Condensed Matter · Physics 2025-12-23 G. Small , F. Ballatore , C. Giverso , V. Balbi

Mechanical characterization of brain tissue at high loading velocities is crucial for modeling Traumatic Brain Injury (TBI). During severe impact conditions, brain tissue experiences compression, tension and shear. Limited experimental data…

Soft Condensed Matter · Physics 2020-09-03 Badar Rashid , Michel Destrade , Michael D. Gilchrist

Traumatic brain injury (TBI) occurs when local mechanical load exceeds certain tolerance levels for brain tissue. Extensive research has been done previously for brain matter experiencing compression at quasistatic loading; however, limited…

Biological Physics · Physics 2013-02-20 Badar Rashid , Michel Destrade , Michael Gilchrist

Brain-computer interfaces (BCIs) make possible to interact with the external environment by decoding the mental intention of individuals. BCIs can therefore be used to address basic neuroscience questions but also to unlock a variety of…

Neurons and Cognition · Quantitative Biology 2021-02-12 Juliana Gonzalez-Astudillo , Tiziana Cattai , Giulia Bassignana , Marie-Constance Corsi , Fabrizio De Vico Fallani

- New advance technologies based on reverse engineering , design and additive manufacturing, have expanded design capabilities for biomedical applications to include Patient Specific Implants (PSI). This change in design paradigms needs…

Medical Physics · Physics 2017-09-21 J. Díaz , Octavio Andrés González-Estrada , C. López

Brain interfaces are cyber-physical systems that aim to harvest information from the (physical) brain through sensing mechanisms, extract information about the underlying processes, and decide/actuate accordingly. Nonetheless, the brain…

Neurons and Cognition · Quantitative Biology 2018-03-29 Gaurav Gupta , Sergio Pequito , Paul Bogdan

Modeling the behavior of coupled networks is challenging due to their intricate dynamics. For example in neuroscience, it is of critical importance to understand the relationship between the functional neural processes and anatomical…

Machine Learning · Computer Science 2021-04-20 Hongyuan You , Sikun Lin , Ambuj K. Singh

Computational simulations using methods such as the finite element (FE) method rely on high-quality meshes for achieving accurate results. This study introduces a method for creating a high-quality hexahedral mesh using the Open Anatomy…

Computational Engineering, Finance, and Science · Computer Science 2024-02-23 Andy Trung Huynh , Benjamin Zwick , Michael Halle , Adam Wittek , Karol Miller

Mechanical models of brain tissue are a beneficial tool to simulate neurosurgical interventions, disease progression, or brain development. However, the accuracy and predictive capacity of such a model relies on a precise experimental…

Medical Physics · Physics 2026-05-29 Laura Ruhland , Nina Reiter , Silvia Budday , Kai Willner

During severe impact conditions, brain tissue experiences a rapid and complex deformation, which can be seen as a mixture of compression, tension and shear. Moreover, diffuse axonal injury (DAI) occurs in animals and humans when both the…

Soft Condensed Matter · Physics 2020-09-04 Badar Rashid , Michel Destrade , Michael D. Gilchrist

Our knowledge of the organisation of the human brain at the population-level is yet to translate into power to predict functional differences at the individual-level, limiting clinical applications, and casting doubt on the generalisability…

Neurons and Cognition · Quantitative Biology 2024-04-04 James K Ruffle , Robert J Gray , Samia Mohinta , Guilherme Pombo , Chaitanya Kaul , Harpreet Hyare , Geraint Rees , Parashkev Nachev

Mammography is a specific type of breast imaging that uses low-dose X-rays to detect cancer in early stage. During the exam, the women breast is compressed between two plates until a nearly uniform breast thickness is obtained. This…

Medical Physics · Physics 2018-11-26 Mîra Anna , Ann-Katherine Carton , Serge Muller , Yohan Payan

Studying the peeling behaviour of adhesives on skin is vital for advancing biomedical applications such as medical adhesives and transdermal patches. Traditional methods like experimental testing and finite element method (FEM), though…

Medical Physics · Physics 2025-06-26 Ashish Masarkar , Rakesh Gupta , Naga Neehar Dingari , Beena Rai

Brain-computer interfaces (BCIs) enable users to interact with the external world using brain activity. Despite their potential in neuroscience and industry, BCI performance remains inconsistent in noninvasive applications, often…

Neurons and Cognition · Quantitative Biology 2024-07-17 Juliana Gonzalez-Astudillo , Fabrizio De Vico Fallani

There is increasing evidence on the importance of brain morphology in predicting and classifying mental disorders. However, the vast majority of current shape approaches rely heavily on vertex-wise analysis that may not successfully capture…

Computer Vision and Pattern Recognition · Computer Science 2021-05-26 Yuexuan Wu , Suprateek Kundu , Jennifer S. Stevens , Negar Fani , Anuj Srivastava

In order to study the local interactions between facial soft-tissues and a Silhouette Soft suspension suture, a CE marked medical device designed for the repositioning of soft tissues in the face and the neck, Finite element simulations…

Brain mechanics is a topic of deep interest because of the significant role of mechanical cues in both brain function and form. Specifically, capturing the heterogeneous and anisotropic behaviour of cerebral white matter (WM) is extremely…

Soft Condensed Matter · Physics 2021-10-20 Asad Jamal , Andrea Bernardini , Daniele Dini
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