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Cell sorting, the segregation of cells with different properties into distinct domains, is a key phenomenon in biological processes such as embryogenesis. We use a phase-field model of a confluent cell layer to study the role of activity in…

Biological Physics · Physics 2024-03-05 James N. Graham , Guanming Zhang , Julia M. Yeomans

We use state-of-the-art molecular dynamics simulations to study hydrodynamic effects on aging during kinetics of phase separation in a fluid mixture. The domain growth law shows a crossover from a diffusive regime to a viscous hydrodynamic…

Statistical Mechanics · Physics 2015-06-12 Shaista Ahmad , Federico Corberi , Subir K. Das , Eugenio Lippiello , Sanjay Puri , Marco Zannetti

T1 transitions, which are localised cell rearrangements, play an important role in the fluidization of epithelial monolayers. Using a multi-phase field model and an active elastic solid model, we show that although each cell undergoes T1…

Biological Physics · Physics 2025-02-11 Harish P. Jain , Richard D. J. G. Ho , Luiza Angheluta

Phase separation, crucial for spatially segregating biomolecules in cells, is well-understood in the simple case of a few components with pairwise interactions. Yet, biological cells challenge the simple picture in at least two ways: First,…

Soft Condensed Matter · Physics 2024-03-12 Chengjie Luo , Yicheng Qiang , David Zwicker

From the mitotic spindle up to tissues and biofilms, many biological systems behave as active droplets, which often break symmetry and change shape spontaneously. Here, I show that active nematic droplets can experience a fingering…

Soft Condensed Matter · Physics 2022-06-07 Ricard Alert

The hydrodynamic theory of active nematics has been often used to describe the spatio-temporal dynamics of cell flows and motile topological defects within soft confluent tissues. Those theories, however, often rely on the assumption that…

Soft Condensed Matter · Physics 2023-08-15 Ioannis Hadjifrangiskou , Liam J. Ruske , Julia M. Yeomans

Active matter is not only indispensable to our understanding of diverse biological processes, but also provides a fertile ground for discovering novel physics. Many emergent properties impossible for equilibrium systems have been…

Soft Condensed Matter · Physics 2022-05-27 Thibault Bertrand , Chiu Fan Lee

The field of active nematics has traditionally employed descriptions based on dipolar activity, with interactions that align along a single axis. However, it has been theoretically predicted that interactions with a substrate, prevalent in…

Collective actuation in active solids, the spontaneous condensation of the dynamics on a few elastic modes, takes place whenever the deformations of the structure reorient the forces exerted by the active units composing, or embedded in,…

Soft Condensed Matter · Physics 2025-11-21 Paul Baconnier , Vincent Démery , Olivier Dauchot

The biopolymers actin and microtubules are often in an ongoing assembling/disassembling state far from thermal equilibrium. Above a critical density this leads to spatially periodic patterns, as shown by a scaling argument and in terms of a…

Soft Condensed Matter · Physics 2007-05-23 Falko Ziebert , Walter Zimmermann

Topological defects, which are singular points in a director field, play a major role in shaping active systems. Here, we experimentally study topological defects and the flow patterns around them, that are formed during the highly rapid…

Soft Condensed Matter · Physics 2024-03-20 Victor Yashunsky , Daniel J. G. Pearce , Gil Ariel , Avraham Be'er

We consider two minimal models of active fluid droplets that exhibit complex dynamics including steady motion, deformation, rotation and oscillating motion. First we consider a droplet with a concentration of active contractile matter…

Soft Condensed Matter · Physics 2016-12-20 Carl A. Whitfield , Rhoda J. Hawkins

It is increasingly being realized that liquid-crystalline features can play an important role in the properties and dynamics of cell monolayers. Here, we present a cell-based model of cell layers, based on the phase-field formulation, that…

Soft Condensed Matter · Physics 2022-04-28 Aleksandra Ardaševa , Romain Mueller , Amin Doostmohammadi

We study theoretically the effects of confinement on active polar gels such as the actin network of eukaryotic cells. Using generalized hydrodynamics equations derived for active gels, we predict, in the case of quasi one-dimensional…

Subcellular Processes · Quantitative Biology 2015-06-26 R. Voituriez , J-F Joanny , J. Prost

We consider the diffusion-advection problem in two simple cellular flow models (often invoked as examples for subdiffusive tracer's motion) and concentrate on the intermediate time range, in which the tracer's motion indeed may show…

Fluid Dynamics · Physics 2016-09-28 Patrick Pöschke , Igor M. Sokolov , Alexander A. Nepomnyashchy , Michael A. Zaks

Depending on the involved physiobiological parameters, stable or unstable behavior in active fluids is observed. In this paper a rigorous analytical justification of (in-)stability within the corresponding regimes is given. In particular,…

Analysis of PDEs · Mathematics 2023-08-03 Christiane Bui , Christian Gesse , Jürgen Saal

How particles are deposited at the edge of evaporating droplets, i.e. the {\em coffee ring} effect, plays a crucial role in phenomena as diverse as thin-film deposition, self-assembly, and biofilm formation. Recently, microorganisms have…

Hydrodynamic interactions between fluid-dispersed particles are ubiquitous in soft matter and biological systems and they give rise to intriguing collective phenomena. While it was reported that these interactions can facilitate…

Soft Condensed Matter · Physics 2022-08-29 Eric Cereceda-López , Dominik Lips , Antonio Ortiz-Ambriz , Artem Ryabov , Philipp Maass , Pietro Tierno

We study the effects of externally applied shear flow on a model of suspensions of motors and filaments, via the equations of active hydrodynamics [PRL {\bf 89} (2002) 058101; {\bf 92} (2004) 118101]. In the absence of shear, the…

Soft Condensed Matter · Physics 2009-11-11 Sudipto Muhuri , Madan Rao , Sriram Ramaswamy

Elongated active units cannot spontaneously break rotation symmetry in bulk fluids to form nematic or polar phases. This has led to the image of active suspensions as spontaneously evolving, spatiotemporally chaotic fluids. In contrast, I…

Soft Condensed Matter · Physics 2023-01-16 Ananyo Maitra