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Cell alignment often forms nematic order, which can lead to anomalous collective cell flow due to the so-called active force. Although it is appreciated that cell migration is driven by traction force, a quantitative evaluation of the…

Soft Condensed Matter · Physics 2024-02-27 Masahito Uwamichi , He Li , Zihui Zhao , Yisong Yao , Hideo Higuchi , Kyogo Kawaguchi , Masaki Sano

The interplay between active matter and its environment is central to understanding emergent behavior in biological and synthetic systems. Here, we show that coupling active nematic flows to small-amplitude deformations of a compliant…

Soft Condensed Matter · Physics 2026-01-19 Varun Venkatesh , Amin Doostmohammadi

Spatiotemporal patterns in multicellular systems are important to understanding tissue dynamics, for instance, during embryonic development and disease. Here, we use a multiphase field model to study numerically the behavior of a…

Soft Condensed Matter · Physics 2025-02-13 Michael Chiang , Austin Hopkins , Benjamin Loewe , M. Cristina Marchetti , Davide Marenduzzo

Confluent cell monolayers and epithelia tissues show remarkable patterns and correlations in structural arrangements and actively-driven collective flows. We simulate these properties using multiphase field models. The models are based on…

Soft Condensed Matter · Physics 2021-12-08 Dennis Wenzel , Axel Voigt

The ability of cells to reorganize in response to external stimuli is important in areas ranging from morphogenesis to tissue engineering. Elongated cells can co-align due to steric effects, forming states with local order. We show that…

Experimental evidence shows that there is a feedback between cell shape and cell motion. How this feedback impacts the collective behavior of dense cell monolayers remains an open question. We investigate the effect of a feedback that tends…

Aging in kinetics of three different phase transitions, viz., magnetic, binary solid and single component fluid, have been studied via Monte Carlo and molecular dynamics simulations in three space dimensions with the objective of…

Statistical Mechanics · Physics 2015-06-15 Suman Majumder , Subir K. Das

Living cells and tissues can generate complex patterns of electric fields and fluid flows which can play important role in physiology. Both, fields and flows are rooted in ion transport across biological interfaces: cell membranes and…

Soft Condensed Matter · Physics 2026-05-22 Amit Singh Vishen , Ahandeep Manna , Frank Jülicher

Because active particles break time-reversal symmetry, an active fluid can sustain currents even without an external drive. We show that when a passive body is placed in a fluid of pairwise interacting active particles, it generates…

Statistical Mechanics · Physics 2020-08-26 Omer Granek , Yongjoo Baek , Yariv Kafri , Alexandre P. Solon

We study the role of hydrodynamic interactions in the collective behaviour of collections of microscopic active particles suspended in a fluid. We introduce a novel calculational framework that allows us to separate the different…

Soft Condensed Matter · Physics 2017-09-06 Natsuhiko Yoshinaga , Tanniemola B. Liverpool

There is now growing evidence of the emergence and biological functionality of liquid crystal features, including nematic order and topological defects, in cellular tissues. However, how such features that intrinsically rely on particle…

Soft Condensed Matter · Physics 2019-02-06 Romain Mueller , Julia Yeomans , Amin Doostmohammadi

Active forces occurring within cells can drive crucial biological processes that involve spontaneous organization and shape change, such as cell division. Motivated by recent in vitro experiments of nematic droplets of cytoskeletal…

Soft Condensed Matter · Physics 2021-02-16 Fabian Jan Schwarzendahl , Pierre Ronceray , Kimberly L. Weirich , Kinjal Dasbiswas

The nature of emergent collective behaviors of moving physical agents interacting with their neighborhood is a long-standing open issue in physical and biological systems alike. This calls for studies on the control of synchronization and…

Statistical Mechanics · Physics 2017-08-11 Tirthankar Banerjee , Abhik Basu

Cell crawling crucially depends on the collective dynamics of the acto-myosin cytoskeleton. However, it remains an open question to what extent cell polarization and persistent motion depend on continuous regulatory mechanisms and…

Biological Physics · Physics 2023-08-11 Fenna Stegemerten , Karin John , Uwe Thiele

Incorporating the inherent heterogeneity of living systems into models of active nematics is essential to provide a more realistic description of biological processes such as bacterial growth, cell dynamics and tissue development.…

Soft Condensed Matter · Physics 2024-11-06 Alexander J. H. Houston , Nigel J. Mottram

We study how hydrodynamic interactions affect the collective behaviour of active particles suspended in a fluid at high concentrations, with particular attention to lubrication forces which appear when the particles are very close to one…

Soft Condensed Matter · Physics 2018-05-29 Natsuhiko Yoshinaga , Tanniemola B. Liverpool

We use a computational phase-field model together with analytical analysis to study how inter-cellular active forces can mediate individual cell morphology and collective motion in a confluent cell monolayer. Contractile inter-cellular…

Soft Condensed Matter · Physics 2021-11-30 Guanming Zhang , Julia M. Yeomans

We use a continuum, two-fluid approach to study a mixture of two active nematic fluids. Even in the absence of thermodynamically-driven ordering, for mixtures of different activities we observe turbulent microphase separation, where domains…

Soft Condensed Matter · Physics 2025-02-03 Saraswat Bhattacharyya , Julia M. Yeomans

We use linear stability analysis to show that an isotropic phase of elongated particles with dipolar flow fields can develop nematic order as a result of their activity. We argue that ordering is favoured if the particles are flow-aligning…

Soft Condensed Matter · Physics 2020-03-18 Sreejith Santhosh , Mehrana R. Nejad , Amin Doostmohammadi , Julia M. Yeomans , Sumesh P. Thampi

We report computer simulation results on the cluster formation of dipolar colloidal particles driven by a rotating external field in a quasi-two-dimensional setup. We focus on the interplay between permanent dipolar and hydrodynamic…

Soft Condensed Matter · Physics 2015-06-12 Sebastian Jäger , Holger Stark , Sabine H. L. Klapp
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