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Background: Due to the finite size of the development sample, predicted probabilities from a risk prediction model are inevitably uncertain. We apply Value of Information methodology to evaluate the decision-theoretic implications of…

Applications · Statistics 2022-04-15 Mohsen Sadatsafavi , Tae Yoon Lee , Paul Gustafson

Decision makers involved in the management of civil assets and systems usually take actions under constraints imposed by societal regulations. Some of these constraints are related to epistemic quantities, as the probability of failure…

Artificial Intelligence · Computer Science 2021-06-10 Shuo Li , Matteo Pozzi

Health impact simulation models are used to predict how a proposed intervention or scenario will affect public health outcomes, based on available data and knowledge of the process. The outputs of these models are uncertain due to…

In designing external validation studies of clinical prediction models, contemporary sample size calculation methods are based on the frequentist inferential paradigm. One of the widely reported metrics of model performance is net benefit…

Applications · Statistics 2025-02-28 Mohsen Sadatsafavi , Andrew J Vickers , Tae Yoon Lee , Paul Gustafson , Laure Wynants

Background: Before being used to inform patient care, a risk prediction model needs to be validated in a representative sample from the target population. The finite size of the validation sample entails that there is uncertainty with…

Applications · Statistics 2023-07-20 Mohsen Sadatsafavi , Tae Yoon Lee , Laure Wynants , Andrew Vickers , Paul Gustafson

Risk prediction models are often advertised as deterministic functions that map covariates to predicted risks. However, they are typically trained using finite samples, and as such, their predictions are inherently uncertain. This…

Methodology · Statistics 2025-06-03 Abdollah Safari , Paul Gustafson , Mohsen Sadatsafavi

Background: The Expected Value of Sample Information (EVSI) determines the economic value of any future study with a specific design aimed at reducing uncertainty in a health economic model. This has potential as a tool for trial design;…

Methodology · Statistics 2018-04-26 Anna Heath , Ioanna Manolopoulou , Gianluca Baio

In medical decision making, we have to choose among several expensive diagnostic tests such that the certainty about a patient's health is maximized while remaining within the bounds of resources like time and money. The expected increase…

Artificial Intelligence · Computer Science 2019-09-19 Sarthak Ghosh , C. R. Ramakrishnan

Weighted Majority Voting (WMV) is a well-known optimal decision rule for collective decision making, given the probability of sources to provide accurate information (trustworthiness). However, in reality, the trustworthiness is not a known…

Artificial Intelligence · Computer Science 2024-07-02 Shaojie Bai , Dongxia Wang , Tim Muller , Peng Cheng , Jiming Chen

By employing various empirical estimators for the Mutual Information (MI) measure, we calculate and compare the estimates and their confidence intervals for both normal and non-normal bivariate data samples. We find that certain nonlinear…

Information Theory · Computer Science 2024-10-10 Theo Grigorenko , Leo Grigorenko

Computing value of information (VOI) is a crucial task in various aspects of decision-making under uncertainty, such as in meta-reasoning for search; in selecting measurements to make, prior to choosing a course of action; and in managing…

Artificial Intelligence · Computer Science 2015-03-13 David Tolpin , Solomon Eyal Shimony

Background: The Expected Value of Sample Information (EVSI) calculates the value of collecting additional information through a study with a given design. Standard EVSI analyses assume that the treatment recommendations based on the new…

Methodology · Statistics 2021-05-14 Anna Heath

One of the most complex tasks of decision making and planning is to gather information. This task becomes even more complex when the state is high-dimensional and its belief cannot be expressed with a parametric distribution. Although the…

Artificial Intelligence · Computer Science 2022-09-26 Gilad Rotman , Vadim Indelman

Economic and financial theories and practice essentially deal with uncertain future. Humans encounter uncertainty in different kinds of activity, from sensory-motor control to dynamics in financial markets, what has been subject of…

Statistical Finance · Quantitative Finance 2021-10-08 Felix Polyakov

Decision making in modern stochastic systems, including e-commerce platforms, financial markets and healthcare systems, has evolved into a multifaceted process that combines information acquisition and adaptive information sources. This…

Optimization and Control · Mathematics 2026-01-07 Renyuan Xu , Thaleia Zariphopoulou , Luhao Zhang

Suppose we have a Bayesian model which combines evidence from several different sources. We want to know which model parameters most affect the estimate or decision from the model, or which of the parameter uncertainties drive the decision…

Applications · Statistics 2021-11-25 Christopher Jackson , Anne Presanis , Stefano Conti , Daniela De Angelis

In ecological and environmental contexts, management actions must sometimes be chosen urgently. Value of information (VoI) analysis provides a quantitative toolkit for projecting the improved management outcomes expected after making…

When humans infer underlying probabilities from stochastic observations, they exhibit biases and variability that cannot be explained on the basis of sound, Bayesian manipulations of probability. This is especially salient when beliefs are…

Neurons and Cognition · Quantitative Biology 2021-07-08 Arthur Prat-Carrabin , Florent Meyniel , Misha Tsodyks , Rava Azeredo da Silveira

Objectives: Value of information (VOI) analyses can help policy-makers make informed decisions about whether to conduct and how to design future studies. Historically, a computationally expensive method to compute the Expected Value of…

In an era of data abundance, statistical evidence is increasingly critical for business and policy decisions. Yet, organizations lack empirical tools to assess the value of evidence-based decision making (EBDM), optimize statistical…

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