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The Gene or DNA sequence in every cell does not control genetic properties on its own; Rather, this is done through translation of DNA into protein and subsequent formation of a certain 3D structure. The biological function of a protein is…

Computational Engineering, Finance, and Science · Computer Science 2019-05-30 Leila Khalatbari , Mohammad Reza Kangavari , Saeid Hosseini , Hongzhi Yin , Ngai-Man Cheung

Developing increasingly efficient and accurate algorithms for approximate nearest neighbor search is a paramount goal in modern information retrieval. A primary approach to addressing this question is clustering, which involves partitioning…

Information Retrieval · Computer Science 2024-12-10 Thomas Vecchiato

The generation of protein crystals is necessary for the study of protein molecular function and structure. This is done empirically by processing large numbers of crystallization trials and inspecting them regularly in search of those with…

Computer Vision and Pattern Recognition · Computer Science 2018-05-15 Soheil Ghafurian , Peter Orth , Corey Strickland , Hua Su , Sangita Patel , Steven Soisson , Belma Dogdas

Particle competition and cooperation (PCC) is a graph-based semi-supervised learning approach. When PCC is applied to interactive image segmentation tasks, pixels are converted into network nodes, and each node is connected to its k-nearest…

Computer Vision and Pattern Recognition · Computer Science 2020-02-17 Fabricio Breve

Pharmaceutical researchers are continually searching for techniques to improve both drug development processes and patient outcomes. An area of recent interest is the potential for machine learning (ML) applications within pharmacology. One…

Applications · Statistics 2024-06-26 Jackson P. Lautier , Stella Grosser , Jessica Kim , Hyewon Kim , Junghi Kim

We propose a weakly-supervised cell tracking method that can train a convolutional neural network (CNN) by using only the annotation of "cell detection" (i.e., the coordinates of cell positions) without association information, in which…

Computer Vision and Pattern Recognition · Computer Science 2020-07-31 Kazuya Nishimura , Junya Hayashida , Chenyang Wang , Dai Fei Elmer Ker , Ryoma Bise

k is the most important parameter in a text categorization system based on k-Nearest Neighbor algorithm (kNN).In the classification process, k nearest documents to the test one in the training set are determined firstly. Then, the…

Computation and Language · Computer Science 2007-05-23 Baoli Li , Shiwen Yu , Qin Lu

In this work, we propose a novel hybrid method for scene text detection namely Correlation Propagation Network (CPN). It is an end-to-end trainable framework engined by advanced Convolutional Neural Networks. Our CPN predicts text objects…

Computer Vision and Pattern Recognition · Computer Science 2018-10-02 Zichuan Liu , Guosheng Lin , Wang Ling Goh , Fayao Liu , Chunhua Shen , Xiaokang Yang

Research in neural models inspired by mammal's visual cortex has led to many spiking neural networks such as pulse-coupled neural networks (PCNNs). These models are oscillating, spatio-temporal models stimulated with images to produce…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Nurul Rafi , Pablo Rivas

This paper suggests the use of projective clustering based product quantization for improving nearest neighbor and max-inner-product vector search (MIPS) algorithms. We provide anisotropic and quantized variants of projective clustering…

Data Structures and Algorithms · Computer Science 2021-12-07 Aditya Krishnan , Edo Liberty

Learning scientific document representations can be substantially improved through contrastive learning objectives, where the challenge lies in creating positive and negative training samples that encode the desired similarity semantics.…

Computation and Language · Computer Science 2022-10-20 Malte Ostendorff , Nils Rethmeier , Isabelle Augenstein , Bela Gipp , Georg Rehm

Sequence alignment is a cornerstone technique in computational biology for assessing similarities and differences among biological sequences. A key variant, sequence-to-graph alignment, plays a crucial role in effectively capturing genetic…

Computational Complexity · Computer Science 2026-02-16 Xingfu Li

Motivated by applications in computer vision and databases, we introduce and study the Simultaneous Nearest Neighbor Search (SNN) problem. Given a set of data points, the goal of SNN is to design a data structure that, given a collection of…

Data Structures and Algorithms · Computer Science 2016-04-11 Piotr Indyk , Robert Kleinberg , Sepideh Mahabadi , Yang Yuan

Locating the center of convex objects is important in both image processing and unsupervised machine learning/data clustering fields. The automated analysis of biological images uses both of these fields for locating cell nuclei and for…

Computer Vision and Pattern Recognition · Computer Science 2018-04-12 James Kapaldo , Xu Han , Domingo Mery

Identifying relationships between molecular variations and their clinical presentations has been challenged by the heterogeneous causes of a disease. It is imperative to unveil the relationship between the high dimensional molecular…

Methodology · Statistics 2021-09-02 Wennan Chang , Changlin Wan , Yong Zang , Chi Zhang , Sha Cao

The prediction of protein structures from sequences is an important task for function prediction, drug design, and related biological processes understanding. Recent advances have proved the power of language models (LMs) in processing the…

Quantitative Methods · Quantitative Biology 2022-12-01 Bozhen Hu , Jun Xia , Jiangbin Zheng , Cheng Tan , Yufei Huang , Yongjie Xu , Stan Z. Li

Detection of cell nuclei in microscopic images is a challenging research topic, because of limitations in cellular image quality and diversity of nuclear morphology, i.e. varying nuclei shapes, sizes, and overlaps between multiple cell…

Computer Vision and Pattern Recognition · Computer Science 2018-07-10 Mohammad Tofighi , Tiantong Guo , Jairam K. P. Vanamala , Vishal Monga

Image segmentation is a fundamental task in computer vision. Data annotation for training supervised methods can be labor-intensive, motivating unsupervised methods. Current approaches often rely on extracting deep features from pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2023-08-22 Amit Aflalo , Shai Bagon , Tamar Kashti , Yonina Eldar

Recent work on deep clustering has found new promising methods also for constrained clustering problems. Their typically pairwise constraints often can be used to guide the partitioning of the data. Many problems however, feature…

Machine Learning · Computer Science 2023-05-22 Jonas K. Falkner , Lars Schmidt-Thieme

A difficult problem in clustering is how to handle data with a manifold structure, i.e. data that is not shaped in the form of compact clouds of points, forming arbitrary shapes or paths embedded in a high-dimensional space. In this work we…

Computer Vision and Pattern Recognition · Computer Science 2010-06-15 Ariel E. Baya , Pablo M. Granitto