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Sparse autoencoders (SAEs) have emerged as a promising approach for learning interpretable features from neural network activations. However, the optimization landscape for SAE training can be challenging due to correlations in the input…

Machine Learning · Computer Science 2025-11-19 Ashwin Saraswatula , David Klindt

RFdiffusion is a popular and well-established model for generation of protein structures. However, this generative process offers limited insight into its internal representations and how they contribute to the final protein structure.…

Quantitative Methods · Quantitative Biology 2025-12-01 Wojciech Zarzecki , Paulina Szymczak , Ewa Szczurek , Kamil Deja

Although sparse autoencoders (SAEs) are crucial for identifying interpretable features in neural networks, it is still challenging to distinguish between real computational patterns and erroneous correlations. We introduce Model-X knockoffs…

Machine Learning · Computer Science 2025-11-18 Tsogt-Ochir Enkhbayar

Sparse autoencoders (SAEs) are useful for detecting and steering interpretable features in neural networks, with particular potential for understanding complex multimodal representations. Given their ability to uncover interpretable…

Computer Vision and Pattern Recognition · Computer Science 2025-05-29 Vladimir Zaigrajew , Hubert Baniecki , Przemyslaw Biecek

We present neuron embeddings, a representation that can be used to tackle polysemanticity by identifying the distinct semantic behaviours in a neuron's characteristic dataset examples, making downstream manual or automatic interpretation…

Machine Learning · Computer Science 2024-11-14 Alex Foote

Steering has emerged as a promising approach in controlling large language models (LLMs) without modifying model parameters. However, most existing steering methods rely on large-scale datasets to learn clear behavioral information, which…

Machine Learning · Computer Science 2025-10-06 Anyi Wang , Xuansheng Wu , Dong Shu , Yunpu Ma , Ninghao Liu

Sparse Autoencoders (SAEs) extract interpretable features from Large Language Models, but standard variants enforce non-negativity, forcing separate latents for diametrically opposed concepts (e.g., "pressure too high" vs. "pressure too…

Learning a generative model of visual information with sparse and compositional features has been a challenge for both theoretical neuroscience and machine learning communities. Sparse coding models have achieved great success in explaining…

Machine Learning · Computer Science 2021-01-26 Linxing Preston Jiang , Luciano de la Iglesia

While sparse autoencoders (SAEs) successfully extract interpretable features from language models, applying them to audio generation faces unique challenges: audio's dense nature requires compression that obscures semantic meaning, and…

Machine Learning · Computer Science 2025-10-31 Nathan Paek , Yongyi Zang , Qihui Yang , Randal Leistikow

Protein language models have revolutionized structure prediction, but their nonlinear nature obscures how sequence representations inform structure prediction. While sparse autoencoders (SAEs) offer a path to interpretability here by…

Biomolecules · Quantitative Biology 2025-03-13 Nithin Parsan , David J. Yang , John J. Yang

Mechanistic interpretability aims to decompose neural networks into interpretable features and map their connecting circuits. The standard approach trains sparse autoencoders (SAEs) on each layer's activations. However, SAEs trained in…

Machine Learning · Computer Science 2025-11-12 Sean P. Fillingham , Andrew Gordon , Peter Lai , Xavier Poncini , David Quarel , Stefan Heimersheim

Sparse Autoencoders (SAEs) that can accurately reconstruct their input (minimizing distortion) by making efficient use of few features (minimizing the rate) often fail to learn monosemantic representations (highly interpretable), limiting…

Machine Learning · Computer Science 2026-05-15 Tommaso Mencattini , Francesco Montagna , Francesco Locatello

It is assumed that sparse autoencoders (SAEs) decompose polysemantic activations into interpretable linear directions, as long as the activations are composed of sparse linear combinations of underlying features. However, we find that if an…

Machine Learning · Computer Science 2025-09-29 David Chanin , Tomáš Dulka , Adrià Garriga-Alonso

Sparse autoencoders (SAEs) are now standard tools for decomposing language model activations into interpretable features, and automated interpretability pipelines routinely assign each feature a short natural-language explanation. Existing…

Machine Learning · Computer Science 2026-05-14 Jordan F. McCann

Sparse autoencoders (SAEs) are designed to extract interpretable features from language models by enforcing a sparsity constraint. Ideally, training an SAE would yield latents that are both sparse and semantically meaningful. However, many…

Machine Learning · Computer Science 2025-11-06 Xiaoqing Sun , Alessandro Stolfo , Joshua Engels , Ben Wu , Senthooran Rajamanoharan , Mrinmaya Sachan , Max Tegmark

The linear representation hypothesis states that neural network activations encode high-level concepts as linear mixtures. However, under superposition, this encoding is a projection from a higher-dimensional concept space into a…

Machine Learning · Computer Science 2026-03-31 Vitória Barin Pacela , Shruti Joshi , Isabela Camacho , Simon Lacoste-Julien , David Klindt

Background: Single-cell foundation models such as Geneformer and scGPT encode rich biological information, but whether this includes causal regulatory logic rather than statistical co-expression remains unclear. Sparse autoencoders (SAEs)…

Genomics · Quantitative Biology 2026-03-04 Ihor Kendiukhov

Sparse autoencoders (SAEs) offer a natural path toward comparable explanations across different representation spaces. However, current SAEs are trained per modality, producing dictionaries whose features are not directly understandable and…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Difei Gu , Yunhe Gao , Gerasimos Chatzoudis , Zihan Dong , Guoning Zhang , Bangwei Guo , Yang Zhou , Mu Zhou , Dimitris Metaxas

Sparse autoencoders (SAEs) have become a standard tool for mechanistic interpretability in autoregressive large language models (LLMs), enabling researchers to extract sparse, human-interpretable features and intervene on model behavior.…

Machine Learning · Computer Science 2026-02-06 Xu Wang , Bingqing Jiang , Yu Wan , Baosong Yang , Lingpeng Kong , Difan Zou

Graph self-supervised learning seeks to learn effective graph representations without relying on labeled data. Among various approaches, graph autoencoders (GAEs) have gained significant attention for their efficiency and scalability.…

Machine Learning · Computer Science 2025-06-17 Yang Liu , Deyu Bo , Wenxuan Cao , Yuan Fang , Yawen Li , Chuan Shi
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