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In situations where it is difficult to enroll patients in randomized controlled trials, external data can improve efficiency and feasibility. In such cases, adaptive trial designs could be used to decrease enrollment in the control arm of…

Methodology · Statistics 2020-10-02 Brian D. Segal , W. Katherine Tan

Individualized treatment effect lies at the heart of precision medicine. Interpretable individualized treatment rules (ITRs) are desirable for clinicians or policymakers due to their intuitive appeal and transparency. The gold-standard…

Methodology · Statistics 2021-08-20 Lili Wu , Shu Yang

Data fusion and transfer learning are rapidly growing fields that enhance model performance for a target population by leveraging other related data sources or tasks. The challenges lie in the various potential heterogeneities between the…

Machine Learning · Statistics 2025-08-19 Jing Wang , HaiYing Wang , Kun Chen

As clinical decision-making increasingly moves toward individualized and context-specific treatment recommendations, reliance on any single evidence source, randomized or observational, may be insufficient. Principled integration of…

Transfer learning is a valuable tool in deep learning as it allows propagating information from one "source dataset" to another "target dataset", especially in the case of a small number of training examples in the latter. Yet,…

Machine Learning · Computer Science 2023-06-13 Daniel Jakubovitz , David Uliel , Miguel Rodrigues , Raja Giryes

Transfer learning has emerged as a powerful technique in many application problems, such as computer vision and natural language processing. However, this technique is largely ignored in application to genetic data analysis. In this paper,…

Applications · Statistics 2022-06-22 Jinghang Lin , Shan Zhang , Qing Lu

Randomized controlled trials are not only the golden standard in medicine and vaccine trials but have spread to many other disciplines like behavioral economics, making it an important interdisciplinary tool for scientists. When designing…

Methodology · Statistics 2021-11-30 Tassilo Schwarz

One approach for increasing the efficiency of randomized trials is the use of "external controls" -- individuals who received the control treatment studied in the trial during routine practice or in prior experimental studies. Existing…

Randomized controlled trials (RCTs) are the gold standard for evaluating causal effects but are often costly and difficult to scale; consequently, they are frequently augmented with auxiliary external controls in many applications. Prior…

Methodology · Statistics 2026-05-28 Jiawei Shan , Yiteng Tu , Guanbo Wang , Chao Ying , Jiwei Zhao

Randomized clinical trials are considered the gold standard for informing treatment guidelines, but results may not generalize to real-world populations. Generalizability is hindered by distributional differences in baseline covariates and…

Methodology · Statistics 2025-06-03 Rachael K. Ross , Ivan Diaz , Amy J. Pitts , Elizabeth A. Stuart , Kara E. Rudolph

This paper considers the estimation and prediction of a high-dimensional linear regression in the setting of transfer learning, using samples from the target model as well as auxiliary samples from different but possibly related regression…

Methodology · Statistics 2020-06-19 Sai Li , T. Tony Cai , Hongzhe Li

Transfer learning aims to improve performance on a target task by leveraging information from related source tasks. We propose a nonparametric regression transfer learning framework that explicitly models heterogeneity in the source-target…

Statistics Theory · Mathematics 2026-03-19 Hélène Halconruy , Benjamin Bobbia , Paul Lejamtel

Randomization, as a key technique in clinical trials, can eliminate sources of bias and produce comparable treatment groups. In randomized experiments, the treatment effect is a parameter of general interest. Researchers have explored the…

Methodology · Statistics 2023-12-05 Fuyi Tu , Wei Ma , Hanzhong Liu

In many business settings, task-specific labeled data are scarce or costly to obtain, limiting supervised learning on a target task. A classical response is transfer learning (TL). Many TL works study how to transfer information from…

Machine Learning · Statistics 2026-05-14 Hamza Cherkaoui , Hélène Halconruy , Yohan Petetin

Transfer learning enhances model performance by utilizing knowledge from related domains, particularly when labeled data is scarce. While existing research addresses transfer learning under various distribution shifts in independent…

Machine Learning · Computer Science 2025-04-30 Liyuan Wang , Jiachen Chen , Kathryn L. Lunetta , Danyang Huang , Huimin Cheng , Debarghya Mukherjee

In this work, we study the transfer learning problem under high-dimensional generalized linear models (GLMs), which aim to improve the fit on target data by borrowing information from useful source data. Given which sources to transfer, we…

Machine Learning · Statistics 2022-04-19 Ye Tian , Yang Feng

With the development of new sensors and monitoring devices, more sources of data become available to be used as inputs for machine learning models. These can on the one hand help to improve the accuracy of a model. On the other hand,…

Machine Learning · Statistics 2023-11-07 Luis Pedro Silvestrin , Harry van Zanten , Mark Hoogendoorn , Ger Koole

We present a Transfer Causal Learning (TCL) framework when target and source domains share the same covariate/feature spaces, aiming to improve causal effect estimation accuracy in limited data. Limited data is very common in medical…

Machine Learning · Computer Science 2024-01-02 Song Wei , Hanyu Zhang , Ronald Moore , Rishikesan Kamaleswaran , Yao Xie

Many existing transfer learning methods rely on leveraging information from source data that closely resembles the target data. However, this approach often overlooks valuable knowledge that may be present in different yet potentially…

Machine Learning · Computer Science 2023-09-14 Xin Xiong , Zijian Guo , Tianxi Cai

Transfer learning is a very important tool in deep learning as it allows propagating information from one "source dataset" to another "target dataset", especially in the case of a small number of training examples in the latter. Yet,…

Machine Learning · Computer Science 2020-01-24 Daniel Jakubovitz , Miguel R. D. Rodrigues , Raja Giryes