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The flow of motor proteins on a filamental track is modelled within the the framework of lattice driven diffusive systems. Motors, considered as hopping particles, perform a highly biased asymmetric exclusion process when bound to the…

Statistical Mechanics · Physics 2007-05-23 M. Ebrahim Fouladvand , Modjtaba Salehi , Mostafa Yadegari

In this paper, dynamical systems theory and bifurcation theory are applied to investi- gate the rich dynamical behaviours observed in three simple disease models. The 2- and 3-dimensional models we investigate have arisen in previous…

Dynamical Systems · Mathematics 2015-04-22 Wenjing Zhang , Pei Yu , Lindi M. Wahl

The bacterial flagellar motor is a highly efficient rotary machine used by many bacteria to propel themselves. It has recently been shown that at low speeds its rotation proceeds in steps [Sowa et al. (2005) Nature 437, 916--919]. Here we…

Biological Physics · Physics 2009-10-25 Thierry Mora , Howard Yu , Yoshiyuki Sowa , Ned S. Wingreen

We consider a one-dimensional version of a variational model for pattern formation in biological membranes. The driving term in the energy is a coupling between the order parameter and the local curvature of the membrane. We derive scaling…

Analysis of PDEs · Mathematics 2024-09-25 Janusz Ginster , Anastasija Pešić , Barbara Zwicknagl

Single molecular rotor is an important component for constructing bot-tom-up molecular mechanical machines and a window for shedding light on complex physical and chemical questions about motions of organic molecules on surfaces. Stability…

Mesoscale and Nanoscale Physics · Physics 2022-04-05 Kwan Ho Au Yeung , Tim Kühne , Frank Eisenhut , Francesca Moresco

This paper presents an algorithm for approximating certain types of dynamical systems given by a system of ordinary delay differential equations by a Boolean network model. Often Boolean models are much simpler to understand than complex…

Molecular Networks · Quantitative Biology 2011-05-10 Franziska Hinkelmann , Reinhard Laubenbacher

We find a statistical mechanism that can adjust orientations of intracellular filaments to cell geometry in absence of organizing centers. The effect is based on random and isotropic filament (de-)polymerization dynamics and is independent…

Biological Physics · Physics 2015-05-28 Philip Greulich , Ludger Santen

The aim of this paper is to study the steady states of the mathematical models with delay kernels which describe pathogen-immune dynamics of many kinds of infectious diseases. In the study of mathematical models of infectious diseases it is…

Dynamical Systems · Mathematics 2007-05-23 M. Neamtu , L. Buliga , F. R. Horhat , D. Opris , A. T. Ceausu

A simple flashing ratchet model in two dimensions is proposed to simulate the hand-over-hand motion of two head molecular motors like kinesin. Extensive Langevin simulations of the model are performed. Good qualitative agreement with the…

Biological Physics · Physics 2008-03-18 Javier Munarriz , Juan J. Mazo , Fernando Falo

Force fluctuations exhibited in focal adhesions (FAs) that connect a cell to its extracellular environment, point to the complex role of the underlying machinery that controls cell migration. To elucidate the explicit role of myosin motors…

Biological Physics · Physics 2022-03-29 Debsuvra Ghosh , Subhadip Ghosh , Abhishek Chaudhuri

Motor proteins that specifically interact with the ends of cytoskeletal filaments can induce filament depolymerization. A phenomenological description of this process is presented. We show that under certain conditions motors dynamically…

Subcellular Processes · Quantitative Biology 2009-11-11 Gernot A. Klein , Karsten Kruse , Gianaurelio Cuniberti , Frank Juelicher

In recent years, several artificial molecular motors driven and controlled by electric currents have been proposed. Similar to Brownian machines, these systems work by turning random inelastic tunneling events into a directional rotation of…

Mesoscale and Nanoscale Physics · Physics 2022-10-31 Federico D. Ribetto , Sebastián E. Deghi , Hernán L. Calvo , Raúl A. Bustos-Marún

We study a model of synthetic molecular motor - a [3]-catenane consisting of two small macrocycles mechanically interlocked with a bigger one - subjected to a time-dependent driving using stochastic thermodynamics. The model presents…

Statistical Mechanics · Physics 2023-06-28 Massimo Bilancioni , Massimiliano Esposito , Emanuele Penocchio

A simple model is proposed that describes the various morphodynamic principles of migrating cells from polar to amoeboidal motions. The model equation is derived using competing internal cellular compass variables and symmetries of the…

Cell Behavior · Quantitative Biology 2013-01-30 Shuji Ishihara

Simulations can help unravel the complicated ways in which molecular structure determines function. Here, we use molecular simulations to show how slight alterations of a molecular motor's structure can cause the motor's typical dynamical…

Statistical Mechanics · Physics 2023-08-21 Alex Albaugh , Geyao Gu , Todd R. Gingrich

Using a simple model, we study the fluctuating dynamics of inextensible, semiflexible polar filaments interacting with active and directed force generating centres such as molecular motors. Taking into account the fact that the activity…

Soft Condensed Matter · Physics 2009-11-07 Tanniemola B. Liverpool

Recently, it has been shown that properties of excitable media stirred by two-dimensional chaotic flows can be properly studied in a one-dimensional framework \cite{excitablePRL,excitablePRE}, describing the transverse profile of the…

Chaotic Dynamics · Physics 2009-11-10 Emilio Hernandez-Garcia , Cristobal Lopez , Zoltan Neufeld

We present a generic coarse-grained model to describe molecular motors acting on polymer substrates, mimicking, for example, RNA polymerase on DNA or kinesin on microtubules. The polymer is modeled as a connected chain of beads; motors are…

Soft Condensed Matter · Physics 2020-10-14 M. Foglino , E. Locatelli , C. A. Brackley , D. Michieletto , C. Likos , D. Marenduzzo

We study the dynamics of a model of membrane vesicle transport into dendritic spines, which are bulbous intracellular compartments in neurons driven by molecular motors. We reduce the lubrication model proposed in [Fai et al., Active…

Cell Behavior · Quantitative Biology 2020-11-19 Youngmin Park , Thomas G. Fai

E. coli bacteria swim following a run and tumble pattern. In the run state all flagella join in a single helical bundle that propels the cell body along approximately straight paths. When one or more flagellar motors reverse direction the…

Soft Condensed Matter · Physics 2015-07-01 S. Bianchi , F. Saglimbeni , A. Lepore , R. Di Leonardo