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We introduce SAM4MLLM, an innovative approach which integrates the Segment Anything Model (SAM) with Multi-Modal Large Language Models (MLLMs) for pixel-aware tasks. Our method enables MLLMs to learn pixel-level location information without…

Artificial Intelligence · Computer Science 2024-12-17 Yi-Chia Chen , Wei-Hua Li , Cheng Sun , Yu-Chiang Frank Wang , Chu-Song Chen

The clinical utility of deep learning models for medical image segmentation is severely constrained by their inability to generalize to unseen domains. This failure is often rooted in the models learning spurious correlations between…

Computer Vision and Pattern Recognition · Computer Science 2026-01-19 Tao Tang , Shijie Xu , Jionglong Su , Zhixiang Lu

A major focus of clinical imaging workflow is disease diagnosis and management, leading to medical imaging datasets strongly tied to specific clinical objectives. This scenario has led to the prevailing practice of developing task-specific…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Yunhe Gao , Zhuowei Li , Di Liu , Mu Zhou , Shaoting Zhang , Dimitris N. Metaxas

Medical image segmentation of tumors and organs at risk is a time-consuming yet critical process in the clinic that utilizes multi-modality imaging (e.g, different acquisitions, data types, and sequences) to increase segmentation precision.…

Image and Video Processing · Electrical Eng. & Systems 2023-06-07 Qisheng He , Nicholas Summerfield , Ming Dong , Carri Glide-Hurst

Tongue imaging serves as a valuable diagnostic tool, particularly in Traditional Chinese Medicine (TCM). The quality of tongue surface segmentation significantly affects the accuracy of tongue image classification and subsequent diagnosis…

Image and Video Processing · Electrical Eng. & Systems 2025-08-22 Jiacheng Xie , Ziyang Zhang , Biplab Poudel , Congyu Guo , Yang Yu , Guanghui An , Xiaoting Tang , Lening Zhao , Chunhui Xu , Dong Xu

Large Language Models (LLMs) demonstrate strong capabilities in broad knowledge representation, yet they are inherently deficient in pixel-level perceptual understanding. Although the Segment Anything Model (SAM) represents a significant…

Computer Vision and Pattern Recognition · Computer Science 2026-01-29 Hao Wang , Limeng Qiao , Zequn Jie , Zhijian Huang , Chengjian Feng , Qingfang Zheng , Lin Ma , Xiangyuan Lan , Xiaodan Liang

Today, deep convolutional neural networks (CNNs) have demonstrated state of the art performance for supervised medical image segmentation, across various imaging modalities and tasks. Despite early success, segmentation networks may still…

Computer Vision and Pattern Recognition · Computer Science 2020-11-24 Rosana El Jurdi , Caroline Petitjean , Paul Honeine , Veronika Cheplygina , Fahed Abdallah

Computed tomography (CT) is extensively used for accurate visualization and segmentation of organs and lesions. While deep learning models such as convolutional neural networks (CNNs) and vision transformers (ViTs) have significantly…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Yuheng Li , Yuxiang Lai , Maria Thor , Deborah Marshall , Zachary Buchwald , David S. Yu , Xiaofeng Yang

Obtaining large pre-trained models that can be fine-tuned to new tasks with limited annotated samples has remained an open challenge for medical imaging data. While pre-trained deep networks on ImageNet and vision-language foundation models…

Computer Vision and Pattern Recognition · Computer Science 2023-11-21 Duy M. H. Nguyen , Hoang Nguyen , Nghiem T. Diep , Tan N. Pham , Tri Cao , Binh T. Nguyen , Paul Swoboda , Nhat Ho , Shadi Albarqouni , Pengtao Xie , Daniel Sonntag , Mathias Niepert

Medical image segmentation remains challenging due to limited annotations for training, ambiguous anatomical features, and domain shifts. While vision-language models such as CLIP offer strong cross-modal representations, their potential…

Computer Vision and Pattern Recognition · Computer Science 2026-02-25 Taha Koleilat , Hojat Asgariandehkordi , Omid Nejati Manzari , Berardino Barile , Yiming Xiao , Hassan Rivaz

This paper proposes LLaFS, the first attempt to leverage large language models (LLMs) in few-shot segmentation. In contrast to the conventional few-shot segmentation methods that only rely on the limited and biased information from the…

Computer Vision and Pattern Recognition · Computer Science 2024-04-04 Lanyun Zhu , Tianrun Chen , Deyi Ji , Jieping Ye , Jun Liu

Parotid gland lesion segmentation is essential for the treatment of parotid gland diseases. However, due to the variable size and complex lesion boundaries, accurate parotid gland lesion segmentation remains challenging. Recently, the…

Computer Vision and Pattern Recognition · Computer Science 2025-08-14 Zhongyuan Wu , Chuan-Xian Ren , Yu Wang , Xiaohua Ban , Jianning Xiao , Xiaohui Duan

While the Segment Anything Model (SAM) excels in semantic segmentation for general-purpose images, its performance significantly deteriorates when applied to medical images, primarily attributable to insufficient representation of medical…

Computer Vision and Pattern Recognition · Computer Science 2023-11-07 Yiming Zhang , Tianang Leng , Kun Han , Xiaohui Xie

Widely adopted medical image segmentation methods, although efficient, are primarily deterministic and remain poorly amenable to natural language prompts. Thus, they lack the capability to estimate multiple proposals, human interaction, and…

Computer Vision and Pattern Recognition · Computer Science 2026-01-23 Yuan Lin , Murong Xu , Marc Hölle , Chinmay Prabhakar , Andreas Maier , Vasileios Belagiannis , Bjoern Menze , Suprosanna Shit

Transfer learning is a critical technique in training deep neural networks for the challenging medical image segmentation task that requires enormous resources. With the abundance of medical image data, many research institutions release…

Computer Vision and Pattern Recognition · Computer Science 2023-07-25 Yuncheng Yang , Meng Wei , Junjun He , Jie Yang , Jin Ye , Yun Gu

Segmentation of anatomical structures and pathological regions in medical images is essential for modern clinical diagnosis, disease research, and treatment planning. While significant advancements have been made in deep learning-based…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Taha Koleilat , Hojat Asgariandehkordi , Hassan Rivaz , Yiming Xiao

In the past ten years, with the help of deep learning, especially the rapid development of deep neural networks, medical image analysis has made remarkable progress. However, how to effectively use the relational information between various…

Computer Vision and Pattern Recognition · Computer Science 2023-03-29 Zhihua Liu

The advancement of artificial intelligence (AI) for organ segmentation and tumor detection is propelled by the growing availability of computed tomography (CT) datasets with detailed, per-voxel annotations. However, these AI models often…

Image and Video Processing · Electrical Eng. & Systems 2024-05-29 Jie Liu , Yixiao Zhang , Kang Wang , Mehmet Can Yavuz , Xiaoxi Chen , Yixuan Yuan , Haoliang Li , Yang Yang , Alan Yuille , Yucheng Tang , Zongwei Zhou

Automated segmentation is a fundamental medical image analysis task, which enjoys significant advances due to the advent of deep learning. While foundation models have been useful in natural language processing and some vision tasks for…

Computer Vision and Pattern Recognition · Computer Science 2025-05-12 Hanxue Gu , Haoyu Dong , Jichen Yang , Maciej A. Mazurowski

Deep learning empowers the mainstream medical image segmentation methods. Nevertheless current deep segmentation approaches are not capable of efficiently and effectively adapting and updating the trained models when new incremental…

Computer Vision and Pattern Recognition · Computer Science 2023-09-06 Zhanghexuan Ji , Dazhou Guo , Puyang Wang , Ke Yan , Le Lu , Minfeng Xu , Jingren Zhou , Qifeng Wang , Jia Ge , Mingchen Gao , Xianghua Ye , Dakai Jin