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Recent advances in large language models (LLMs) have shown great potential to accelerate drug discovery. However, the specialized nature of biochemical data often necessitates costly domain-specific fine-tuning, posing major challenges.…

Machine Learning · Computer Science 2025-11-17 Namkyeong Lee , Edward De Brouwer , Ehsan Hajiramezanali , Tommaso Biancalani , Chanyoung Park , Gabriele Scalia

The BioModels database is one of the premier databases for computational models in systems biology. The database contains over 1000 curated models and an even larger number of non-curated models. All the models are stored in the…

Molecular Networks · Quantitative Biology 2026-02-02 Bhavyahshree Navaneetha Krishnan , Adel Heydarabadipour , Herbert Sauro

Predictive models often need to work with incomplete information in real-world tasks. Consequently, they must provide reliable probability or confidence estimation, especially in large-scale decision-making and planning tasks. Current large…

Computation and Language · Computer Science 2025-10-22 Yu Feng , Ben Zhou , Weidong Lin , Dan Roth

This article introduces Bio-Eng-LMM AI chatbot, a versatile platform designed to enhance user interaction for educational and research purposes. Leveraging cutting-edge open-source Large Language Models (LLMs), Bio-Eng-LMM operates as a…

Systems and Control · Electrical Eng. & Systems 2025-04-22 Ali Forootani , Danial Esmaeili Aliabadi , Daniela Thraen

Large language models (LLMs) are powerful artificial intelligence (AI) tools transforming how research is conducted. However, their use in research has been met with skepticism, due to concerns about hallucinations, biases and potential…

Artificial Intelligence · Computer Science 2025-07-08 Ruian Ke , Ruy M. Ribeiro

Large Language Models (LLMs) have extended their impact beyond Natural Language Processing, substantially fostering the development of interdisciplinary research. Recently, various LLM-based agents have been developed to assist scientific…

Large language model (LLM)-based educational assistants often provide direct answers that short-circuit learning by reducing exploration, self-explanation, and engagement with course materials. We present BLADE (Better Language Answers…

Human-Computer Interaction · Computer Science 2026-04-07 Chathuri Jayaweera , Bonnie J. Dorr

The application of Large Language Models (LLMs) for Automated Algorithm Discovery (AAD), particularly for optimisation heuristics, is an emerging field of research. This emergence necessitates robust, standardised benchmarking practices to…

Software Engineering · Computer Science 2025-04-30 Niki van Stein , Anna V. Kononova , Haoran Yin , Thomas Bäck

Digital health tools have the potential to significantly improve the delivery of healthcare services. However, their adoption remains comparatively limited due, in part, to challenges surrounding usability and trust. Large Language Models…

Computation and Language · Computer Science 2024-03-01 Fergus Imrie , Paulius Rauba , Mihaela van der Schaar

There is widespread optimism that frontier Large Language Models (LLMs) and LLM-augmented systems have the potential to rapidly accelerate scientific discovery across disciplines. Today, many benchmarks exist to measure LLM knowledge and…

In computational biophysics, where molecular data is expanding rapidly and system complexity is increasing exponentially, large language models (LLMs) and agent-based systems are fundamentally reshaping the field. This perspective article…

The rise of large language models (LLMs) has revolutionized user interactions with knowledge-based systems, enabling chatbots to synthesize vast amounts of information and assist with complex, exploratory tasks. However, LLM-based chatbots…

Human-Computer Interaction · Computer Science 2024-11-01 Yingzhe Peng , Xiaoting Qin , Zhiyang Zhang , Jue Zhang , Qingwei Lin , Xu Yang , Dongmei Zhang , Saravan Rajmohan , Qi Zhang

The emergence of Large Language Models (LLMs) has revolutionized how users access information, shifting from traditional search engines to direct question-and-answer interactions with LLMs. However, the widespread adoption of LLMs has…

Computation and Language · Computer Science 2024-07-23 Weihang Su , Yichen Tang , Qingyao Ai , Changyue Wang , Zhijing Wu , Yiqun Liu

Large language models (LLMs) have emerged as powerful tools for medical information retrieval, yet their accuracy and depth remain limited in specialized domains such as Alzheimer's disease (AD), a growing global health challenge. To…

Large language models (LLMs) are increasingly being recognised as valuable knowledge communication tools in many industries. However, their application in livestock farming remains limited, being constrained by several factors not least the…

Artificial Intelligence · Computer Science 2025-09-15 Nana Han , Dong Liu , Tomas Norton

Large language models (LLMs) are a class of artificial intelligence models based on deep learning, which have great performance in various tasks, especially in natural language processing (NLP). Large language models typically consist of…

Quantitative Methods · Quantitative Biology 2025-02-04 Jiajia Liu , Mengyuan Yang , Yankai Yu , Haixia Xu , Tiangang Wang , Kang Li , Xiaobo Zhou

Large language models (LLMs) such as ChatGPT have gained considerable interest across diverse research communities. Their notable ability for text completion and generation has inaugurated a novel paradigm for language-interfaced problem…

Quantitative Methods · Quantitative Biology 2024-02-22 Hengchuang Yin , Zhonghui Gu , Fanhao Wang , Yiparemu Abuduhaibaier , Yanqiao Zhu , Xinming Tu , Xian-Sheng Hua , Xiao Luo , Yizhou Sun

In recent years, data science agents powered by Large Language Models (LLMs), known as "data agents," have shown significant potential to transform the traditional data analysis paradigm. This survey provides an overview of the evolution,…

Artificial Intelligence · Computer Science 2025-12-01 Maojun Sun , Ruijian Han , Binyan Jiang , Houduo Qi , Defeng Sun , Yancheng Yuan , Jian Huang

The landscape of education is changing rapidly, shaped by emerging pedagogical approaches, technological innovations such as artificial intelligence (AI), and evolving societal expectations, all of which demand thorough evaluation of new…

Computers and Society · Computer Science 2026-03-19 Fiammetta Caccavale , Carina L. Gargalo , Julian Kager , Magdalena Skowyra , Steen Larsen , Krist V. Gernaey , Ulrich Krühne

Large Language Models (LLMs) have shown much promise in powering a variety of software engineering (SE) tools. Offering natural language as an intuitive interaction mechanism, LLMs have recently been employed as conversational ``programming…

Software Engineering · Computer Science 2026-04-15 Jonan Richards
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