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The living cell expends energetic and material resources to reliably process information from its environment. To do so, it utilises unreliable molecular circuitry that is subject to thermal and other fluctuations. Here, we argue that…

Soft Condensed Matter · Physics 2022-04-12 Kabir Husain , Sriram Ramaswamy , Madan Rao

We numerically examine binary-sized granular mixtures confined between two parallel walls subjected to vertical vibration using the discrete element method. For a size ratio of $3$ between large and small particles, we study the structure…

Soft Condensed Matter · Physics 2026-05-26 Fumiaki Nakai , Kiwamu Yoshii

We show that systematic particle rotations in a fluid composed of disk-shaped spinners can spontaneously lead to phase separation. The phenomenon arises out of a homogeneous and hydrostatic stationary state, due to a pressure feedback…

Soft Condensed Matter · Physics 2026-05-28 Pasquale Digregorio , Ignacio Pagonabarraga , Francisco Vega Reyes

Many biological tissues feature a heterogeneous network of fibers whose tensile and bending rigidity contribute substantially to these tissues' elastic properties. Rigidity percolation has emerged as a important paradigm for relating these…

The spontaneous generation of electrical activity underpins a number of essential physiological processes, and is observed even in tissues where specialized pacemaker cells have not been identified. The emergence of periodic oscillations in…

Adaptation and Self-Organizing Systems · Physics 2022-02-01 Ria Ghosh , Shakti N. Menon

We formulate a phenomenological model for the segregation of binary mixtures of rough and smooth granular materials in a rotating drum. Our model successfully replicates a range of experimental behaviours, e.g., rapid radial segregation;…

Condensed Matter · Physics 2007-05-23 Sanjay Puri , Hisao Hayakawa

Motility induced phase separation is an efficient aggregation mechanism of active matter, yet biological systems exhibit richer organization through communication among constituents. We investigate suspensions of active particles that…

Soft Condensed Matter · Physics 2025-08-18 Yuxin Zhou , Qingqing Yin , Shubhadip Nayak , Poulami Bag , Pulak K. Ghosh , Yunyun Li , Fabio Marchesoni

Contraction of the cytokinetic ring during cell division leads to physical partitioning of a eukaryotic cell into two daughter cells. This involves flows of actin filaments and myosin motors in the growing membrane interface at the…

Biological Physics · Physics 2022-02-21 Mainak Chatterjee , Arkya Chatterjee , Amitabha Nandi , Anirban Sain

We investigate how an externally imposed curvature influences lipid segregation on two-phase-coexistent membranes. We show that the bending-modulus contrast of the two phases and the curvature act together to yield a reduced effective line…

Soft Condensed Matter · Physics 2018-06-21 Fangfu Ye , Robin L. B. Selinger , Jonathan V. Selinger

We demonstrate how concepts of statistical mechanics of interacting particles can have important implications in the choice of interaction potentials to model qualitative properties of cell aggregates in theoretical biology. We illustrate…

Cell Behavior · Quantitative Biology 2017-06-29 J. A. Carrillo , A. Colombi , M. Scianna

Interactions between crawling cells, which are essential for many biological processes, can be quantified by measuring cell-cell collisions. Conventionally, experiments of cell-cell collisions are conducted on two-dimensional flat…

Biological Physics · Physics 2025-10-24 Yongtian Luo , Amrinder S. Nain , Brian A. Camley

The directed migration of cells toward stiffer substrate regions or durotaxis is relevant to tissue development and tumor progression. Here, we introduce a phenomenological model for single cell durotaxis that incorporates both elastic…

Soft Condensed Matter · Physics 2024-12-24 Subhaya Bose , Haiqin Wang , Xinpeng Xu , Arvind Gopinath , Kinjal Dasbiswas

Mechanical interactions between biological cells may be mediated by secreted products, making them dependent on the local particle density. Here, we explore the generic physics of density-dependent attractive interactions. We show using…

Soft Condensed Matter · Physics 2017-11-29 Gavin Melaugh , Davide Marenduzzo , Alexander Morozov , Rosalind J. Allen

Cellular aggregates play a significant role in the evolution of biological systems such as tumor growth, tissue spreading, wound healing, and biofilm formation. Analysis of such biological systems, in principle, includes examining the…

Numerical Analysis · Mathematics 2022-08-17 Soheil Firooz , Stefan Kaessmair , Vasily Zaburdaev , Ali Javili , Paul Steinmann

Droplets are essential for spatially controlling biomolecules in cells. To work properly, cells need to control the emergence and morphology of droplets. On the one hand, driven chemical reactions can affect droplets profoundly. For…

Soft Condensed Matter · Physics 2024-03-14 Noah Ziethen , David Zwicker

Confining surfaces play crucial roles in dynamics, transport and order in many physical systems, but their effects on active matter, a broad class of dynamically self-organizing systems, are poorly understood. We investigate here the…

Soft Condensed Matter · Physics 2013-07-23 Hugo Wioland , Francis G. Woodhouse , Jörn Dunkel , John O. Kessler , Raymond E. Goldstein

2-TIPS (Two Temperature induced phase separation) refers to the phase separation phenomenon observed in mixtures of active and passive particles which are modelled using scalar activity. The active particles are connected to a thermostat at…

Soft Condensed Matter · Physics 2023-11-07 Nayana Venkatareddy , Jaydeep Mandal , Prabal K. Maiti

We study the kinetics of two-temperature induced phase separation (2-TIPS) in dilute binary mixtures of active ("hot") and passive ("cold") particles using molecular dynamics simulations and a coarse-grained hydrodynamic model. Following a…

Soft Condensed Matter · Physics 2025-12-23 Nayana Venkatareddy , Partha Sarathi Mondal , Shradha Mishra , Prabal K. Maiti

Many organisms exhibit branching morphologies that twist around each other and become entangled. Entanglement occurs when different objects interlock, creating complex and often irreversible configurations. This physical phenomenon is…

Phase separating systems that are maintained away from thermodynamic equilibrium via molecular processes represent a class of active systems, which we call active emulsions. These systems are driven by external energy input for example…

Soft Condensed Matter · Physics 2019-06-07 Christoph A. Weber , David Zwicker , Frank Jülicher , Chiu Fan Lee
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