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The ChatGPT, a lite and conversational variant of Generative Pretrained Transformer 4 (GPT-4) developed by OpenAI, is one of the milestone Large Language Models (LLMs) with billions of parameters. LLMs have stirred up much interest among…

Computation and Language · Computer Science 2023-08-01 Hanyao Huang , Ou Zheng , Dongdong Wang , Jiayi Yin , Zijin Wang , Shengxuan Ding , Heng Yin , Chuan Xu , Renjie Yang , Qian Zheng , Bing Shi

Recent studies have augmented large language models (LLMs) with speech capabilities, leading to the development of speech language models (SpeechLMs). Earlier SpeechLMs focused on single-turn speech-based question answering (QA), where user…

Computation and Language · Computer Science 2025-02-10 Yifan Peng , Krishna C. Puvvada , Zhehuai Chen , Piotr Zelasko , He Huang , Kunal Dhawan , Ke Hu , Shinji Watanabe , Jagadeesh Balam , Boris Ginsburg

With the advent of large language models (LLMs), in both the open source and proprietary domains, attention is turning to how to exploit such artificial intelligence (AI) systems in assisting complex scientific tasks, such as material…

Human-Computer Interaction · Computer Science 2024-01-26 Yongtao Liu , Marti Checa , Rama K. Vasudevan

Large language models (LLMs) such as those embedded in 'chatbots' are accelerating and democratizing research by providing comprehensible information and expertise from many different fields. However, these models may also confer easy…

Computers and Society · Computer Science 2023-06-07 Emily H. Soice , Rafael Rocha , Kimberlee Cordova , Michael Specter , Kevin M. Esvelt

The transition of Large Language Models (LLMs) from exploratory tools to active "silicon subjects" in social science lacks extensive validation of operational validity. This study introduces Conditioned Comment Prediction (CCP), a task in…

Computation and Language · Computer Science 2026-03-27 Nils Schwager , Simon Münker , Alistair Plum , Achim Rettinger

Large language models (LLMs) have recently been applied in software engineering to perform tasks such as translating code between programming languages, generating code from natural language, and autocompleting code as it is being written.…

Human-Computer Interaction · Computer Science 2023-02-15 Steven I. Ross , Fernando Martinez , Stephanie Houde , Michael Muller , Justin D. Weisz

Recent advancements in Large Language Models (LLMs) have demonstrated exceptional capabilities in natural language understanding and generation. While these models excel in general complex reasoning tasks, they still face challenges in…

Artificial Intelligence · Computer Science 2024-10-25 Graziano A. Manduzio , Federico A. Galatolo , Mario G. C. A. Cimino , Enzo Pasquale Scilingo , Lorenzo Cominelli

Large Language Models (LLMs) have demonstrated surprising performance across various natural language processing tasks. Recently, medical LLMs enhanced with domain-specific knowledge have exhibited excellent capabilities in medical…

Computation and Language · Computer Science 2024-09-24 Jinqiang Wang , Huansheng Ning , Yi Peng , Qikai Wei , Daniel Tesfai , Wenwei Mao , Tao Zhu , Runhe Huang

Proteins adopt multiple structural conformations to perform their diverse biological functions, and understanding these conformations is crucial for advancing drug discovery. Traditional physics-based simulation methods often struggle with…

Biomolecules · Quantitative Biology 2025-03-14 Jiarui Lu , Xiaoyin Chen , Stephen Zhewen Lu , Chence Shi , Hongyu Guo , Yoshua Bengio , Jian Tang

Autonomous tuning of particle accelerators is an active and challenging field of research with the goal of enabling novel accelerator technologies cutting-edge high-impact applications, such as physics discovery, cancer research and…

Computation and Language · Computer Science 2024-05-16 Jan Kaiser , Annika Eichler , Anne Lauscher

Natural language is expected to be a key medium for various human-machine interactions in the era of large language models. When it comes to the biochemistry field, a series of tasks around molecules (e.g., property prediction, molecule…

Computation and Language · Computer Science 2023-06-22 Zheni Zeng , Bangchen Yin , Shipeng Wang , Jiarui Liu , Cheng Yang , Haishen Yao , Xingzhi Sun , Maosong Sun , Guotong Xie , Zhiyuan Liu

The primary aim of this research was to address the limitations observed in the medical knowledge of prevalent large language models (LLMs) such as ChatGPT, by creating a specialized language model with enhanced accuracy in medical advice.…

Computation and Language · Computer Science 2023-06-27 Yunxiang Li , Zihan Li , Kai Zhang , Ruilong Dan , Steve Jiang , You Zhang

We introduce Language Feedback Models (LFMs) that identify desirable behaviour - actions that help achieve tasks specified in the instruction - for imitation learning in instruction following. To train LFMs, we obtain feedback from Large…

Machine Learning · Computer Science 2024-10-11 Victor Zhong , Dipendra Misra , Xingdi Yuan , Marc-Alexandre Côté

This paper presents a study on the integration of domain-specific knowledge in prompt engineering to enhance the performance of large language models (LLMs) in scientific domains. A benchmark dataset is curated to encapsulate the intricate…

Computation and Language · Computer Science 2024-04-24 Hongxuan Liu , Haoyu Yin , Zhiyao Luo , Xiaonan Wang

The latest advancements in AI and deep learning have led to a breakthrough in large language model (LLM)-based agents such as GPT-4. However, many commercial conversational agent development tools are pipeline-based and have limitations in…

Computation and Language · Computer Science 2023-09-08 Mina Foosherian , Hendrik Purwins , Purna Rathnayake , Touhidul Alam , Rui Teimao , Klaus-Dieter Thoben

Background: Large Language Models (LLMs) are transforming artificial intelligence applications in healthcare due to their ability to understand, generate, and summarize complex medical text. They offer valuable support to clinicians,…

Computation and Language · Computer Science 2026-04-14 Subin Santhosh , Farwa Abbas , Hussain Ahmad , Claudia Szabo

Large language models (LLMs) have profoundly transformed natural language applications, with a growing reliance on instruction-based definitions for designing chatbots. However, post-deployment the chatbot definitions are fixed and are…

Machine Learning · Computer Science 2024-02-20 Reshabh K Sharma , Vinayak Gupta , Dan Grossman

Large Language Models(LLMs) have dramatically revolutionized the field of Natural Language Processing(NLP), offering remarkable capabilities that have garnered widespread usage. However, existing interaction paradigms between LLMs and users…

Computation and Language · Computer Science 2024-03-11 Juhao Liang , Ziwei Wang , Zhuoheng Ma , Jianquan Li , Zhiyi Zhang , Xiangbo Wu , Benyou Wang

Large Language Models (LLMs) tend to prioritize adherence to user prompts over providing veracious responses, leading to the sycophancy issue. When challenged by users, LLMs tend to admit mistakes and provide inaccurate responses even if…

Computation and Language · Computer Science 2025-02-06 Wei Chen , Zhen Huang , Liang Xie , Binbin Lin , Houqiang Li , Le Lu , Xinmei Tian , Deng Cai , Yonggang Zhang , Wenxiao Wang , Xu Shen , Jieping Ye

Identification of high affinity drug-target interactions is a major research question in drug discovery. Proteins are generally represented by their structures or sequences. However, structures are available only for a small subset of…

Machine Learning · Computer Science 2020-12-22 Rıza Özçelik , Hakime Öztürk , Arzucan Özgür , Elif Ozkirimli