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Formation of a molecular network from multifunctional precursors is modelled with a random graph process. The random graph model favours reactivity for monomers that are positioned close in the network topology, and disfavours reactivity…

Soft Condensed Matter · Physics 2019-08-21 Ivan Kryven , Jorien Duivenvoorden , Joen Hermans , Piet D. Iedema

Stochastic regularization of neural networks (e.g. dropout) is a wide-spread technique in deep learning that allows for better generalization. Despite its success, continuous-time models, such as neural ordinary differential equation (ODE),…

Machine Learning · Computer Science 2020-06-29 Viktor Oganesyan , Alexandra Volokhova , Dmitry Vetrov

Complex dynamical systems are often modeled as networks, with nodes representing dynamical units which interact through the network's links. Gene regulatory networks, responsible for the production of proteins inside a cell, are an example…

Statistical Mechanics · Physics 2009-09-30 Zoran Levnajić

This work concerns the exponential stabilization of underactuated linear homogeneous systems of m parabolic partial differential equations (PDEs) in cascade (reaction-diffusion systems), where only the first state is controlled either…

Optimization and Control · Mathematics 2023-10-19 Constantinos Kitsos , Emilia Fridman

In this work, a family of finite volume discretization schemes for LWR-type first order traffic flow models (with possible on- and off-ramps) is proposed: the Traffic Reaction Model (TRM). These schemes yield systems of ODEs that are…

Numerical Analysis · Mathematics 2024-01-03 M. Pereira , B. Kulcsár , Gy. Lipták , M. Kovács , G. Szederkényi

The modeling of diffusion processes on graphs is the basis for many network science and machine learning approaches. Entropic measures of network-based diffusion have recently been employed to investigate the reversibility of these…

Dynamical Systems · Mathematics 2025-10-23 Samuel Koovely , Alexandre Bovet

Zero-one reaction networks are pivotal to cellular signaling, and establishing the equivalence of such networks represents a foundational computational challenge in the realm of chemical reaction network research. Herein, we propose a…

Molecular Networks · Quantitative Biology 2026-02-03 Yue Jiao , Xiaoxian Tang

Biological systems encode function not primarily in steady states, but in the structure of transient responses elicited by time-varying stimuli. Overshoots, biphasic dynamics, adaptation kinetics, fold-change detection, entrainment, and…

Quantitative Methods · Quantitative Biology 2026-01-05 Eduardo D. Sontag

We describe a large class of chemical reaction networks, those endowed with a subtle structural property called concordance. We show that the class of concordant networks coincides precisely with the class of networks which, when taken with…

Molecular Networks · Quantitative Biology 2011-09-15 Guy Shinar , Martin Feinberg

We characterize the dynamics of all single-target networks under mass-action kinetics: either the system is (i) globally stable for all choice of rate constants (in fact, dynamically equivalent to a detailed-balanced system) or (ii) has no…

Dynamical Systems · Mathematics 2021-01-19 Gheorghe Craciun , Jiaxin Jin , Polly Y. Yu

Neural Ordinary Differential Equations (NODEs), a framework of continuous-depth neural networks, have been widely applied, showing exceptional efficacy in coping with representative datasets. Recently, an augmented framework has been…

Machine Learning · Computer Science 2023-04-12 Qunxi Zhu , Yao Guo , Wei Lin

This paper presents a stability test for a class of interconnected nonlinear systems motivated by biochemical reaction networks. One of the main results determines global asymptotic stability of the network from the diagonal stability of a…

Quantitative Methods · Quantitative Biology 2007-05-23 Murat Arcak , Eduardo D. Sontag

The paper concerns a class of $n$-dimensional non-autonomous delay differential equations obtained by adding a non-monotone delayed perturbation to a linear homogeneous cooperative system of ordinary differential equations. This family…

Classical Analysis and ODEs · Mathematics 2018-07-10 Teresa Faria , Rafael Obaya , Ana M. Sanz

Graph neural Ordinary Differential Equations (ODE) combine neural ODE with the message passing mechanism of Graph Neural Networks (GNN), providing a continuous-time modeling method for graph representation learning. However, in dynamic…

Machine Learning · Computer Science 2026-04-29 Xiaoyi Wang , Zhiqiang Wang , Jianqing Liang , Xingwang Zhao , Chuangyin Dang , Zhen Jin , Jiye Liang

Resonance is a well-known phenomenon that happens in systems with second order dynamics. In this paper we address the fundamental question of making a network robust to signal being periodically pumped into it at or near a resonant…

Social and Information Networks · Computer Science 2025-01-30 Alp Sahin , Nicolas Kozachuk , Rick S. Blum , Subhrajit Bhattacharya

Bistability and multistationarity are properties of reaction networks linked to switch-like responses and connected to cell memory and cell decision making. Determining whether and when a network exhibits bistability is a hard and open…

Algebraic Geometry · Mathematics 2018-12-20 Elisenda Feliu , Martin Helmer

We consider a finite collection of reinforced stochastic processes with a general network-based interaction among them. We provide sufficient and necessary conditions in order to have some form of almost sure asymptotic synchronization,…

Probability · Mathematics 2025-06-11 Giacomo Aletti , Irene Crimaldi , Andrea Ghiglietti

In this paper we discuss the question of how to decide when a general chemical reaction system is incapable of admitting multiple equilibria, regardless of parameter values such as reaction rate constants, and regardless of the type of…

Dynamical Systems · Mathematics 2009-07-17 Murad Banaji , Gheorghe Craciun

A general system of n ordinary differential equations coupled with one reaction-diffusion equation, considered in a bounded N-dimensional domain, with no-flux boundary condition is studied in a context of pattern formation. Such initial…

Analysis of PDEs · Mathematics 2023-04-14 Szymon Cygan , Grzegorz Karch , Anna Marciniak-Czochra , Kanako Suzuki

We study stationary distributions in the context of stochastic reaction networks. In particular, we are interested in complex balanced reaction networks and reduction of such networks by assuming a set of species (called non-interacting…

Probability · Mathematics 2024-02-06 Linard Hoessly , Carsten Wiuf , Panqiu Xia