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Large language models (LLMs) are approaching expert-level performance in medical question answering (QA), demonstrating strong potential to improve public healthcare. However, underlying biases related to sensitive attributes such as sex…

Artificial Intelligence · Computer Science 2026-01-13 Ying Xiao , Jie Huang , Ruijuan He , Jing Xiao , Mohammad Reza Mousavi , Yepang Liu , Kezhi Li , Zhenpeng Chen , Jie M. Zhang

Recent advancements in Large Language Models (LLMs) have positioned them as powerful tools for clinical decision-making, with rapidly expanding applications in healthcare. However, concerns about bias remain a significant challenge in the…

Artificial Intelligence · Computer Science 2024-10-23 Kenza Benkirane , Jackie Kay , Maria Perez-Ortiz

Medical Question Answering systems based on Retrieval Augmented Generation is promising for clinical decision support because they can integrate external knowledge, thus reducing inaccuracies inherent in standalone large language models…

Computation and Language · Computer Science 2025-03-28 Yuelyu Ji , Hang Zhang , Yanshan Wang

This paper studies the performance of large language models (LLMs), particularly regarding demographic fairness, in solving real-world healthcare tasks. We evaluate state-of-the-art LLMs with three prevalent learning frameworks across six…

Computation and Language · Computer Science 2024-12-10 Yue Zhou , Barbara Di Eugenio , Lu Cheng

This paper introduces MedExQA, a novel benchmark in medical question-answering, to evaluate large language models' (LLMs) understanding of medical knowledge through explanations. By constructing datasets across five distinct medical…

Computation and Language · Computer Science 2024-07-04 Yunsoo Kim , Jinge Wu , Yusuf Abdulle , Honghan Wu

Large language models (LLMs) are increasingly deployed in clinical decision support, yet subtle demographic cues can influence their reasoning. Prior work has documented disparities in outputs across patient groups, but little is known…

Computation and Language · Computer Science 2025-10-16 Rajarshi Ghosh , Abhay Gupta , Hudson McBride , Anurag Vaidya , Faisal Mahmood

Large Language Models (LLMs) have great potential in the field of health care, yet they face great challenges in adapting to rapidly evolving medical knowledge. This can lead to outdated or contradictory treatment suggestions. This study…

Computation and Language · Computer Science 2025-09-09 Weiyi Wu , Xinwen Xu , Chongyang Gao , Xingjian Diao , Siting Li , Lucas A. Salas , Jiang Gui

With the rapid progress of Large Language Models (LLMs), the general public now has easy and affordable access to applications capable of answering most health-related questions in a personalized manner. These LLMs are increasingly proving…

Artificial Intelligence · Computer Science 2025-10-20 Emma Kondrup , Anne Imouza

The integration of large language models (LLMs) into healthcare holds promise to enhance clinical decision-making, yet their susceptibility to biases remains a critical concern. Gender has long influenced physician behaviors and patient…

Large language models (LLMs) show promise for clinical use. They are often evaluated using datasets such as MedQA. However, Many medical datasets, such as MedQA, rely on simplified Question-Answering (Q\A) that underrepresents real-world…

Computation and Language · Computer Science 2025-10-24 Yunpeng Xiao , Carl Yang , Mark Mai , Xiao Hu , Kai Shu

Objectives: To evaluate the current limitations of large language models (LLMs) in medical question answering, focusing on the quality of datasets used for their evaluation. Materials and Methods: Widely-used benchmark datasets, including…

Computation and Language · Computer Science 2025-07-15 Mahmoud Alwakeel , Aditya Nagori , Vijay Krishnamoorthy , Rishikesan Kamaleswaran

Recent advancements in large language models have demonstrated their potential in numerous medical applications, particularly in automating clinical trial matching for translational research and enhancing medical question answering for…

Computation and Language · Computer Science 2024-10-15 Yuelyu Ji , Wenhe Ma , Sonish Sivarajkumar , Hang Zhang , Eugene Mathew Sadhu , Zhuochun Li , Xizhi Wu , Shyam Visweswaran , Yanshan Wang

The deployment of large language models (LLMs) in healthcare has demonstrated substantial potential for enhancing clinical decision-making, administrative efficiency, and patient outcomes. However, the underrepresentation of diverse groups…

While Large Language Models (LLMs) have become ubiquitous in many fields, understanding and mitigating LLM biases is an ongoing issue. This paper provides a novel method for evaluating the demographic biases of various generative AI models.…

Computation and Language · Computer Science 2025-06-16 Jack H Fagan , Ruhaan Juyaal , Amy Yue-Ming Yu , Siya Pun

Large language models (LLMs) hold promise to serve complex health information needs but also have the potential to introduce harm and exacerbate health disparities. Reliably evaluating equity-related model failures is a critical step toward…

Large Language Models (LLMs) have seen widespread deployment in various real-world applications. Understanding these biases is crucial to comprehend the potential downstream consequences when using LLMs to make decisions, particularly for…

Computation and Language · Computer Science 2024-01-10 Abel Salinas , Parth Vipul Shah , Yuzhong Huang , Robert McCormack , Fred Morstatter

Large Language Models (LLMs) have demonstrated significant promise for various applications in healthcare. However, their efficacy in the Arabic medical domain remains unexplored due to the lack of high-quality domain-specific datasets and…

Computation and Language · Computer Science 2025-08-25 Mouath Abu Daoud , Chaimae Abouzahir , Leen Kharouf , Walid Al-Eisawi , Nizar Habash , Farah E. Shamout

Large language models (LLMs) are widely applied across diverse domains, raising concerns about their limitations and potential risks. In this study, we investigate two types of bias that LLMs may display: stereotype bias and deviation bias.…

Computation and Language · Computer Science 2026-05-20 Daniel Wang , Eli Brignac , Minjia Mao , Xiao Fang

Large Language Models (LLMs) in mental healthcare risk propagating biases that reinforce stigma and harm marginalized groups. While previous research identified concerning trends, systematic methods for detecting intersectional biases…

Computation and Language · Computer Science 2025-06-24 Batool Haider , Atmika Gorti , Aman Chadha , Manas Gaur

Large Language Models (LLMs) have the potential of facilitating the development of Artificial Intelligence technology to assist medical experts for interactive decision support, which has been demonstrated by their competitive performances…

Computation and Language · Computer Science 2024-11-12 Iñigo Alonso , Maite Oronoz , Rodrigo Agerri
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