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Early and accurate assessment of brain microstructure using diffusion Magnetic Resonance Imaging (dMRI) is crucial for identifying neurodevelopmental disorders in neonates, but remains challenging due to low signal-to-noise ratio (SNR),…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Haykel Snoussi , Davood Karimi

Accurate local fiber orientation distribution (FOD) modeling based on diffusion magnetic resonance imaging (dMRI) capable of resolving complex fiber configurations benefits from specific acquisition protocols that sample a high number of…

Image and Video Processing · Electrical Eng. & Systems 2020-12-18 Oeslle Lucena , Sjoerd B. Vos , Vejay Vakharia , John Duncan , Keyoumars Ashkan , Rachel Sparks , Sebastien Ourselin

Confocal histology provides an opportunity to establish intra-voxel fiber orientation distributions that can be used to quantitatively assess the biological relevance of diffusion weighted MRI models, e.g., constrained spherical…

Diffusion MRI (dMRI) is a critical non-invasive technique to estimate fiber orientation distribution (FOD) for characterizing white matter integrity. Estimating FOD from single-shell low angular resolution dMRI (LAR-FOD) is limited by…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Hao Tang , Hanyu Liu , Alessandro Perelli , Xi Chen , Chao Li

We present a novel method for estimation of the fiber orientation distribution (FOD) function based on diffusion-weighted Magnetic Resonance Imaging (D-MRI) data. We formulate the problem of FOD estimation as a regression problem through…

Applications · Statistics 2016-12-23 Hao Yan , Owen Carmichael , Debashis Paul , Jie Peng

Diffusion-weighted magnetic resonance imaging (DW-MRI) is the only non-invasive approach for estimation of intra-voxel tissue microarchitecture and reconstruction of in vivo neural pathways for the human brain. With improvement in…

Image and Video Processing · Electrical Eng. & Systems 2020-02-21 Vishwesh Nath , Sudhir K. Pathak , Kurt G. Schilling , Walt Schneider , Bennett A. Landman

Diffusion-weighted magnetic resonance imaging (DW-MRI) is a critical imaging method for capturing and modeling tissue microarchitecture at a millimeter scale. A common practice to model the measured DW-MRI signal is via fiber orientation…

Fiber orientation distribution (FOD) is an advanced diffusion MRI modeling technique that represents complex white matter fiber configurations, and a key step for subsequent brain tractography and connectome analysis. Its reliability and…

Diffusion-weighted magnetic resonance imaging (D-MRI) is an in-vivo and non-invasive imaging technology to probe anatomical architectures of biological samples. The anatomy of white matter fiber tracts in the brain can be revealed to help…

Applications · Statistics 2023-05-18 Jilei Yang , Seungyong Hwang , Jie Peng

Constrained Spherical Deconvolution (CSD) is widely used to estimate the white matter fiber orientation distribution (FOD) from diffusion MRI data. Its angular resolution depends on the maximum spherical harmonic order ($l_{max}$): low…

Due to recent technological advances, large brain imaging data sets can now be collected. Such data are highly complex so extraction of meaningful information from them remains challenging. Thus, there is an urgent need for statistical…

Applications · Statistics 2021-06-30 Seungyong Hwang , Thomas C. M. Lee , Debashis Paul , Jie Peng

Fiber orientation distributions (FODs) is a popular model to represent the diffusion MRI (dMRI) data. However, imaging artifacts such as susceptibility-induced distortion in dMRI can cause signal loss and lead to the corrupted…

Image and Video Processing · Electrical Eng. & Systems 2024-06-21 Shuo Huang , Lujia Zhong , Yonggang Shi

Diffusion magnetic resonance imaging (dMRI) is currently the only tool for noninvasively imaging the brain's white matter tracts. The fiber orientation (FO) is a key feature computed from dMRI for fiber tract reconstruction. Because the…

Computer Vision and Pattern Recognition · Computer Science 2017-05-22 Chuyang Ye , Jerry L. Prince

The connectivity and structural integrity of the white matter of the brain is nowadays known to be implicated into a wide range of brain-related disorders. However, it was not before the advent of diffusion Magnetic Resonance Imaging (dMRI)…

Computer Vision and Pattern Recognition · Computer Science 2014-01-27 Q. Zhou , O. Michailovich , Y. Rathi

Diffusion Magnetic Resonance Imaging (DMRI) is the only non-invasive imaging technique which is able to detect the principal directions of water diffusion as well as neurites density in the human brain. Exploiting the ability of Spherical…

Computer Vision and Pattern Recognition · Computer Science 2017-09-04 Mauro Zucchelli , Maxime Descoteaux , Gloria Menegaz

Diffusion magnetic resonance imaging is sensitive to the microstructural properties of brain tissue. However, estimating clinically and scientifically relevant microstructural properties from the measured signals remains a highly…

Image and Video Processing · Electrical Eng. & Systems 2024-02-27 Leevi Kerkelä , Kiran Seunarine , Filip Szczepankiewicz , Chris A. Clark

This article introduces a new methodology for reconstructing the white matter fiber pathways of brain in diffusion MRI. Usually, the signal intensity values will be lesser in the direction of higher diffusivity. The proposed approach picks…

Neurons and Cognition · Quantitative Biology 2022-07-26 Ashishi Puri , Sanjeev Kumar

Inferring brain connectivity and structure \textit{in-vivo} requires accurate estimation of the orientation distribution function (ODF), which encodes key local tissue properties. However, estimating the ODF from diffusion MRI (dMRI)…

Image and Video Processing · Electrical Eng. & Systems 2024-02-07 William Consagra , Lipeng Ning , Yogesh Rathi

Diffusion MRI offers a unique probe into neural microstructure and connectivity in the developing brain. However, analysis of neonatal brain imaging data is complicated by inevitable subject motion, leading to a series of scattered slices…

Data from diffusion magnetic resonance imaging (dMRI) can be used to reconstruct fiber tracts, for example, in muscle and white matter. Estimation of fiber orientations (FOs) is a crucial step in the reconstruction process and these…

Computer Vision and Pattern Recognition · Computer Science 2016-05-17 Chuyang Ye , Jiachen Zhuo , Rao P. Gullapalli , Jerry L. Prince
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