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In the past decade, enormous progress has been made in advancing the state-of-the-art in bioimage analysis - a young computational field that works in close collaboration with the life sciences on the quantitative analysis of scientific…

Other Quantitative Biology · Quantitative Biology 2023-07-11 Joran Deschamps , Damian Dalle Nogare , Florian Jug

The reproduction and replication of research results has become a major issue for a number of scientific disciplines. In computer science and related computational disciplines such as systems biology, the challenges closely revolve around…

Software Engineering · Computer Science 2017-07-31 Tom Crick , Benjamin A. Hall , Samin Ishtiaq

Computational models have great potential to accelerate bioscience, bioengineering, and medicine. However, it remains challenging to reproduce and reuse simulations, in part, because the numerous formats and methods for simulating various…

Open source software development, particularly within institutions such as universities and research laboratories, is often decentralized and difficult to track. Although academic teams produce many impactful scientific tools, their…

Software Engineering · Computer Science 2026-02-27 Juanita Gomez , Emily Lovell , Stephanie Lieggi , Alvaro A. Cardenas , James Davis

The surge in high-throughput omics data has reshaped the landscape of biological research, underlining the need for powerful, user-friendly data analysis and interpretation tools. This paper presents GenoCraft, a web-based comprehensive…

Artificial intelligence (AI) is increasingly integrated into society, from financial services and traffic management to creative writing. Academic literature on the deployment of AI has mostly focused on the risks and harms that result from…

GitHub is the world's largest platform for collaborative software development, with over 100 million users. GitHub is also used extensively for open data collaboration, hosting more than 800 million open data files, totaling 142 terabytes…

Machine Learning · Computer Science 2023-06-13 Anthony Cintron Roman , Kevin Xu , Arfon Smith , Jehu Torres Vega , Caleb Robinson , Juan M Lavista Ferres

AI systems can now cheaply generate plausible scientific artifacts such as papers, reviews, and surveys. This creates a risk of \emph{epistemic pollution} in our scientific systems, where unreliable but plausible-looking artifacts can…

Computers and Society · Computer Science 2026-05-12 Jiaqi W. Ma

In recent years, data science has become an indispensable part of our society. Over time, we have become reliant on this technology because of its opportunity to gain value and new insights from data in any field - business, socializing,…

Computers and Society · Computer Science 2020-10-28 Dinh-An Ho , Oya Beyan

The next generation of scientific experiments and studies, popularly called as e-Science, is carried out by large collaborations of researchers distributed around the world engaged in analysis of huge collections of data generated by…

Distributed, Parallel, and Cluster Computing · Computer Science 2007-05-23 Srikumar Venugopal , Rajkumar Buyya , Lyle Winton

Cancer is a complex disease driven by genomic alterations, and tumor sequencing is becoming a mainstay of clinical care for cancer patients. The emergence of multi-institution sequencing data presents a powerful resource for learning…

Genomics · Quantitative Biology 2024-10-31 Yuan Chen , Ronglai Shen , Xiwen Feng , Katherine Panageas

As the amount of scientific data continues to grow at ever faster rates, the research community is increasingly in need of flexible computational infrastructure that can support the entirety of the data science lifecycle, including…

Computers and Society · Computer Science 2016-04-12 Robert L. Grossman , Allison Heath , Mark Murphy , Maria Patterson , Walt Wells

Over the last decades, the amount of data of all kinds available electronically has increased dramatically. Data are accessible through a range of interfaces including Web browsers, database query languages, application-specific interfaces,…

Software Engineering · Computer Science 2013-10-01 Gianluca Colombo , Ettore Colombo , Andrea Bonomi , Alessandro Mosca , Simone Bassis

In the evolving landscape of clinical informatics, the integration and utilization of software tools developed through governmental funding represent a pivotal advancement in research and application. However, the dispersion of these tools…

Digital Libraries · Computer Science 2024-03-28 Jeremy R. Harper

As the interplay between human-generated and synthetic data evolves, new challenges arise in scientific discovery concerning the integrity of the data and the stability of the models. In this work, we examine the role of synthetic data as…

Biomedical evidence synthesis relies on accurate extraction of methodological, laboratory, and outcome variables from full-text research articles, yet these variables are embedded in complex scientific PDFs that make manual abstraction…

Computation and Language · Computer Science 2026-01-22 Pouria Mortezaagha , Joseph Shaw , Bowen Sun , Arya Rahgozar

The ever-growing availability of computing power and the sustained development of advanced computational methods have contributed much to recent scientific progress. These developments present new challenges driven by the sheer amount of…

Today's world is a globalized and connected one, where people are increasingly moving around and interacting with a greater number of services and devices of all kinds, including those that allow them to monitor their health. However, each…

Software Engineering · Computer Science 2021-03-10 Javier Rojo , Juan Hernandez , Juan Manuel Murillo , Jose Garcia-Alonso

Healthcare AI holds the potential to increase patient safety, augment efficiency and improve patient outcomes, yet research is often limited by data access, cohort curation, and tooling for analysis. Collection and translation of electronic…

Software Engineering · Computer Science 2021-12-14 Raphael Y. Cohen , Vesela P. Kovacheva

The recent explosion of recorded digital data and its processed derivatives threatens to overwhelm researchers when analysing their experimental data or when looking up data items in archives and file systems. While current hardware…