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Background: Data driven stratification of patients into biologically informed subtypes holds promise for precision neuropsychiatry, yet neuroimaging-based clustering methods often fail to generalize across cohorts. While algorithmic…

Machine Learning · Computer Science 2025-06-12 Yuetong Yu , Ruiyang Ge , Ilker Hacihaliloglu , Alexander Rauscher , Roger Tam , Sophia Frangou

We introduce a method that takes advantage of high-quality pretrained multimodal representations to explore fine-grained semantic networks in the human brain. Previous studies have documented evidence of functional localization in the…

Artificial Intelligence · Computer Science 2023-06-07 Cory Efird , Alex Murphy , Joel Zylberberg , Alona Fyshe

Contemporary neuroimaging methods can shed light on the basis of human neural and cognitive specializations, with important implications for neuroscience and medicine. Different MRI acquisitions provide different brain networks at the…

Neurons and Cognition · Quantitative Biology 2016-02-23 C. Alonso-Montes , I. Diez , L. Remaki , I. Escudero , B. Mateos , Y. Rosseel , D. Marinazzo , S. Stramaglia , J. Cortes

Anatomical connectivity between different regions in the brain can be mapped to a network representation, the connectome, where the intensities of the links, the weights, influence its structural resilience and the functional processes it…

Neurons and Cognition · Quantitative Biology 2025-04-09 Laia Barjuan , Muhua Zheng , M. Ángeles Serrano

Genome-wide association studies (GWAS) suggests that a complex disease is typically affected by many genetic variants with small or moderate effects. Identification of these risk variants remains to be a very challenging problem.…

Methodology · Statistics 2014-01-21 Dongjun Chung , Can Yang , Cong Li , Joel Gelernter , Hongyu Zhao

Analysis of multi-source dataset, where data on the same objects are collected from multiple sources, is of rising importance in many fields, most notably in multi-omics biology. A novel framework and algorithms for integrative…

Methodology · Statistics 2023-03-16 SeoWon Gabriel Choi , Sungkyu Jung

Recent research in neuroimaging has focused on assessing associations between genetic variants that are measured on a genomewide scale and brain imaging phenotypes. A large number of works in the area apply massively univariate analyses on…

Computer-aided diagnosis (CAD) systems play a crucial role in analyzing neuroimaging data for neurological and psychiatric disorders. However, small-sample studies suffer from low reproducibility, while large-scale datasets introduce…

Machine Learning · Computer Science 2025-08-12 Xinglin Zhao , Yanwen Wang , Xiaobo Liu , Yanrong Hao , Rui Cao , Xin Wen

Cyber-physical systems (CPS) integrate sensing, computing, and control to improve infrastructure performance, focusing on economic goals like performance and safety. However, they often neglect potential human-centered (or ''social'')…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Cheyu Lin , John Martins , Katherine A. Flanigan , Ph. D

Understanding the interplay between high-dimensional data from different views is essential in biomedical research, particularly in fields such as genomics, neuroimaging and biobank-scale studies involving high-dimensional features.…

Methodology · Statistics 2026-03-31 Ruyi Pan , Yinqiu He , Jun Young Park

Brain regions are often topographically connected: nearby locations within one brain area connect with nearby locations in another area. Mapping these connection topographies, or 'connectopies' in short, is crucial for understanding how…

Quantitative Methods · Quantitative Biology 2017-07-18 Koen V. Haak , Andre F. Marquand , Christian F. Beckmann

To understand the biological characteristics of neurological disorders with functional connectivity (FC), recent studies have widely utilized deep learning-based models to identify the disease and conducted post-hoc analyses via explainable…

Machine Learning · Computer Science 2023-10-09 Eunsong Kang , Da-woon Heo , Jiwon Lee , Heung-Il Suk

Brain-computer interfaces (BCIs) enable direct communication between the brain and external devices. This review highlights the core decoding algorithms that enable multimodal BCIs, including a dissection of the elements, a unified view of…

Human-Computer Interaction · Computer Science 2025-02-06 Siyang Li , Hongbin Wang , Xiaoqing Chen , Dongrui Wu

Software vulnerability detection can be formulated as a binary classification problem that determines whether a given code snippet contains security defects. Existing multimodal methods typically fuse Natural Code Sequence (NCS)…

Software Engineering · Computer Science 2026-04-24 Yun Bian , Yi Chen , HaiQuan Wang , ShiHao Li , Zhe Cui

Integrating brain imaging data with clinical reports offers a valuable opportunity to leverage complementary multimodal information for more effective and timely diagnosis in practical clinical settings. This approach has gained significant…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Jing Zhang , Xiaowei Yu , Minheng Chen , Lu Zhang , Tong Chen , Yan Zhuang , Chao Cao , Yanjun Lyu , Li Su , Tianming Liu , Dajiang Zhu

Prior work has offered evidence for functional localization in the brain; different anatomical regions preferentially activate for certain types of visual input. For example, the fusiform face area preferentially activates for visual…

Machine Learning · Computer Science 2024-10-02 Cory Efird , Alex Murphy , Joel Zylberberg , Alona Fyshe

Resting-state fMRI has been shown to provide surrogate biomarkers for the analysis of various diseases. In addition, fMRI data helps in understanding the brain's functional working during resting state and task-induced activity. To improve…

Machine Learning · Computer Science 2021-10-11 Dushyant Sahoo , Christos Davatzikos

Multimodal fusion benefits disease diagnosis by providing a more comprehensive perspective. Developing algorithms is challenging due to data heterogeneity and the complex within- and between-modality associations. Deep-network-based…

Neurons and Cognition · Quantitative Biology 2020-06-18 Wenxing Hu , Xianghe Meng , Yuntong Bai , Aiying Zhang , Biao Cai , Gemeng Zhang , Tony W. Wilson , Julia M. Stephen , Vince D. Calhoun , Yu-Ping Wang

Many diffusion MRI researchers, including the Human Connectome Project (HCP), acquire data using multishell (e.g., WU-Minn consortium) and diffusion spectrum imaging (DSI) schemes (e.g., USC-Harvard consortium). However, these data sets are…

Neurons and Cognition · Quantitative Biology 2023-07-28 Fang-Cheng Yeh , Timothy D. Verstynen

We consider exploratory methods for the discovery of cortical functional connectivity. Typically, data for the i-th subject (i=1...NS) is represented as an NVxNT matrix Xi, corresponding to brain activity sampled at NT moments in time from…

Methodology · Statistics 2011-03-17 Roberto D. Pascual-Marqui , Rolando J. Biscay-Lirio