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The tear film (TF) plays a critical role in maintaining ocular surface health, and its disruption through tear breakup (TBU) is closely associated with dry eye disease. Evaporation-driven thinning is a primary mechanism underlying TBU, yet…

Numerical Analysis · Mathematics 2026-05-05 Qinying Chen , Tobin Driscoll

The contribution of different physical effects to tear breakup (TBU) in subjects with no self-reported history of dry eye are quantified. An automated system using a convolutional neural network is deployed on fluorescence (FL) imaging…

The human tear film (TF) is thin multilayer fluid film that is critical for clear vision and ocular surface health. Its dynamics are strongly affected by a floating lipid layer and, in health, that layer slows evaporation and helps create a…

Fluid Dynamics · Physics 2024-04-23 M. J. Taranchuk , R. J. Braun

Purpose: To determine whether evaporation, tangential flow, or a combination of the two cause tear film breakup in a variety of instances; to estimate related breakup parameters that cannot be measured in breakup during subject trials; and…

Fluid Dynamics · Physics 2022-11-10 Rayanne A. Luke , Richard J. Braun , Carolyn G. Begley

Etiologies of tear breakup include evaporation-driven, divergent flow-driven, and a combination of these two. A mathematical model incorporating evaporation and lipid-driven tangential flow is fit to fluorescence imaging data. The…

Dry Eye Disease (DED) is one of the most common ocular diseases: over five percent of US adults suffer from DED. Tear film instability is a known factor for DED, and is thought to be regulated in large part by the thin lipid layer that…

Computer Vision and Pattern Recognition · Computer Science 2022-12-08 Tejasvi Kothapalli , Charlie Shou , Jennifer Ding , Jiayun Wang , Andrew D. Graham , Tatyana Svitova , Stella X. Yu , Meng C. Lin

Motivated by a model proposed by Peng et al. [Advances in Coll. and Interf. Sci. 206 (2014)] for break-up of tear films on human eyes, we study the dynamics of a generalized thin film model. The governing equations form a fourth-order…

Analysis of PDEs · Mathematics 2022-11-08 Yuan Gao , Hangjie Ji , Jian-Guo Liu , Thomas P. Witelski

Fluorescein is perhaps the most commonly used substance to visualize tear film thickness and dynamics; better understanding of this process aids understanding of dry eye syndrome which afflicts millions of people. We study a mathematical…

Quantitative Methods · Quantitative Biology 2016-11-01 Longfei Li , R. J. Braun , W. D. Henshaw , P. E. King-Smith

Using dissipative particle dynamics simulations, we study the effects of an embedding bulk fluid on the phase separation dynamics in a thin planar liquid film. The domain growth exponent is altered from 2D to 3D behavior upon the addition…

Soft Condensed Matter · Physics 2015-05-18 Sanoop Ramachandran , Shigeyuki Komura , Gerhard Gompper

Drying suspensions often leave behind complex patterns of particulates, as might be seen in the coffee stains on a table. Here we consider the dynamics of periodic band or uniform solid film formation on a vertical plate suspended partially…

Soft Condensed Matter · Physics 2014-12-05 C. Nadir Kaplan , Ning Wu , Shreyas Mandre , Joanna Aizenberg , L. Mahadevan

Understanding the dynamics of liquid films that make up bubbles is of practical and fundamental importance. Practically, this understanding is crucial for tuning bubble stability, while fundamentally, thin films are an excellent platform to…

Fluid Dynamics · Physics 2020-04-22 Vineeth Chandran Suja , Alex Hadidi , Aadithya Kannan , Gerald G Fuller

Surface bubbles have attracted much interest in the past decades. In this article, we propose to explore the lifetime and thinning dynamics of centimetric surface bubbles. We study the impact of the bubbles size as well as that of the…

Soft Condensed Matter · Physics 2020-05-28 Jonas Miguet , Marina Pasquet , Florence Rouyer , Yuan Fang , Emmanuelle Rio

We present a model for thin film growth by particle deposition that takes into account the possible evaporation of the particles deposited on the surface. Our model focuses on the formation of two-dimensional structures. We find that the…

Materials Science · Physics 2009-10-28 Pablo Jensen , Hernán Larralde , Alberto Pimpinelli

We study theoretically the evaporation-driven phase separation of a binary fluid mixture in a thin film deposited on a moving substrate, as occurs in meniscus-guided deposition for solution-processed materials. Our focus is on rapid…

Soft Condensed Matter · Physics 2024-07-01 René de Bruijn , Anton A. Darhuber , Jasper J. Michels , Paul van der Schoot

We study numerically the influence of contact angle on slow evaporation in two-dimensional model porous media. For sufficiently low contact angles, the drying pattern is fractal and can be predicted by a simple model combining the invasion…

Soft Condensed Matter · Physics 2009-03-11 Hamza Chraibi , M. Prat , O. Chapuis

The deformation and breakup of droplets in airflows is important in spray and atomisation processes, but the shear effect in non-uniform airflow is rarely reported. In this study, the deformation and breakup of droplets in a shear flow of…

Fluid Dynamics · Physics 2023-01-18 Zhikun Xu , Tianyou Wang , Zhizhao Che

Recent experiments have shown that various structures may be formed during the evaporative dewetting of thin films of colloidal suspensions. Nano-particle deposits of strongly branched `flower-like', labyrinthine and network structures are…

Soft Condensed Matter · Physics 2011-10-03 M. J. Robbins , A. J. Archer , U. Thiele

We consider two dimensional dispersions of droplets of isotropic phase in a liquid with an XY-like order parameter, tilt, nematic, and hexatic symmetries being included. Strong anchoring boundary conditions are assumed. Textures for a…

Soft Condensed Matter · Physics 2008-07-06 K. S. Korolev , David R. Nelson

Tear film (TF) breakup is a key driver of understanding dry eye disease, yet estimating TF thickness and osmolarity from fluorescence (FL) imaging typically requires solving computationally expensive inverse problems. We propose an operator…

Numerical Analysis · Mathematics 2026-01-14 Qinying Chen , Arnab Roy , Tobin A. Driscoll

Transport of viscous fluid through porous media is a direct consequence of the pore structure. Here we investigate transport through a specific class of two-dimensional porous geometries, namely those formed by fluid-mechanical erosion. We…

Fluid Dynamics · Physics 2020-05-20 Shang-Huan Chiu , M. N. J. Moore , Bryan D. Quaife
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