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Instance segmentation for unlabeled imaging modalities is a challenging but essential task as collecting expert annotation can be expensive and time-consuming. Existing works segment a new modality by either deploying a pre-trained model…

Computer Vision and Pattern Recognition · Computer Science 2022-04-08 Leander Lauenburg , Zudi Lin , Ruihan Zhang , Márcia dos Santos , Siyu Huang , Ignacio Arganda-Carreras , Edward S. Boyden , Hanspeter Pfister , Donglai Wei

Instance object segmentation and tracking provide comprehensive quantification of objects across microscope videos. The recent single-stage pixel-embedding based deep learning approach has shown its superior performance compared with…

Image and Video Processing · Electrical Eng. & Systems 2020-11-03 Quan Liu , Isabella M. Gaeta , Mengyang Zhao , Ruining Deng , Aadarsh Jha , Bryan A. Millis , Anita Mahadevan-Jansen , Matthew J. Tyska , Yuankai Huo

Thyroid nodule segmentation in ultrasound images is crucial for accurate diagnosis and treatment planning. However, existing methods face challenges in segmentation accuracy, interpretability, and generalization, which hinder their…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Xinjie Sun , Boxiong Wei , Yalong Jiang , Liquan Mao , Qi Zhao

Manually annotating nuclei from the gigapixel Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs) is a laborious and costly task, meaning automated algorithms for cell nuclei instance segmentation and classification could…

Computer Vision and Pattern Recognition · Computer Science 2024-07-29 João D. Nunes , Diana Montezuma , Domingos Oliveira , Tania Pereira , Jaime S. Cardoso

In this study, we introduce \textbf{AttendSeg}, a low-precision, highly compact deep neural network tailored for on-device semantic segmentation. AttendSeg possesses a self-attention network architecture comprising of light-weight attention…

Computer Vision and Pattern Recognition · Computer Science 2021-05-03 Xiaoyu Wen , Mahmoud Famouri , Andrew Hryniowski , Alexander Wong

Precise instrument segmentation aid surgeons to navigate the body more easily and increase patient safety. While accurate tracking of surgical instruments in real-time plays a crucial role in minimally invasive computer-assisted surgeries,…

Image and Video Processing · Electrical Eng. & Systems 2021-11-11 Juan Carlos Angeles-Ceron , Gilberto Ochoa-Ruiz , Leonardo Chang , Sharib Ali

Image segmentation plays an essential role in nuclei image analysis. Recently, the segment anything model has made a significant breakthrough in such tasks. However, the current model exists two major issues for cell segmentation: (1) the…

Image and Video Processing · Electrical Eng. & Systems 2023-08-24 Qing Xu , Wenwei Kuang , Zeyu Zhang , Xueyao Bao , Haoran Chen , Wenting Duan

Automated cell segmentation is crucial for various biological and medical applications, facilitating tasks like cell counting, morphology analysis, and drug discovery. However, manual segmentation is time-consuming and prone to…

Machine Learning · Computer Science 2024-09-13 Aaron Rock Menezes , Bharath Ramsundar

Deep learning has revolutionized medical and biological imaging, particularly in segmentation tasks. However, segmenting biological cells remains challenging due to the high variability and complexity of cell shapes. Addressing this…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Tianhao Zhang , Heather J. McCourty , Berardo M. Sanchez-Tafolla , Anton Nikolaev , Lyudmila S. Mihaylova

Instance segmentation of biological images is essential for studying object behaviors and properties. The challenges, such as clustering, occlusion, and adhesion problems of the objects, make instance segmentation a non-trivial task.…

Computer Vision and Pattern Recognition · Computer Science 2019-11-22 Jingru Yi , Hui Tang , Pengxiang Wu , Bo Liu , Daniel J. Hoeppner , Dimitris N. Metaxas , Lianyi Han , Wei Fan

Most of the modern instance segmentation approaches fall into two categories: region-based approaches in which object bounding boxes are detected first and later used in cropping and segmenting instances; and keypoint-based approaches in…

Computer Vision and Pattern Recognition · Computer Science 2020-03-17 Xingqian Xu , Mang Tik Chiu , Thomas S. Huang , Honghui Shi

Cells are the fundamental unit of biological organization, and identifying them in imaging data - cell segmentation - is a critical task for various cellular imaging experiments. While deep learning methods have led to substantial progress…

Live cell culture is crucial in biomedical studies for analyzing cell properties and dynamics in vitro. This study focuses on segmenting unstained live cells imaged with bright-field microscopy. While many segmentation approaches exist for…

Quantitative Methods · Quantitative Biology 2025-08-26 Surajit Das , Gourav Roy , Pavel Zun

Obtaining large-scale medical data, annotated or unannotated, is challenging due to stringent privacy regulations and data protection policies. In addition, annotating medical images requires that domain experts manually delineate…

Computer Vision and Pattern Recognition · Computer Science 2025-05-16 Tushar Kataria , Shireen Y. Elhabian

The presented algorithms for segmentation and tracking follow a 3-step approach where we detect, track and finally segment nuclei. In the preprocessing phase, we detect centroids of the cell nuclei using a convolutional neural network (CNN)…

Computer Vision and Pattern Recognition · Computer Science 2019-04-16 Dennis Eschweiler , Johannes Stegmaier

Most state-of-the-art techniques for medical image segmentation rely on deep-learning models. These models, however, are often trained on narrowly-defined tasks in a supervised fashion, which requires expensive labeled datasets. Recent…

Image and Video Processing · Electrical Eng. & Systems 2023-10-04 Heejong Kim , Victor Ion Butoi , Adrian V. Dalca , Daniel J. A. Margolis , Mert R. Sabuncu

Accurate cell segmentation is critical for biological and medical imaging studies. Although recent deep learning models have advanced this task, most methods are limited to generic cell segmentation, lacking the ability to differentiate…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Bisheng Wang , Jaime S. Cardoso , Lin Wu

Deep learning has proven to be more effective than other methods in medical image analysis, including the seemingly simple but challenging task of segmenting individual cells, an essential step for many biological studies. Comparative…

Image and Video Processing · Electrical Eng. & Systems 2023-11-07 Valentina Vadori , Antonella Peruffo , Jean-Marie Graïc , Livio Finos , Livio Corain , Enrico Grisan

Quantifying the number of molecules from fluorescence microscopy measurements is an important topic in cell biology and medical research. In this work, we present a consecutive algorithm for super-resolution (STED) scanning microscopy that…

Applications · Statistics 2023-10-03 Katharina Proksch , Frank Werner , Jan Keller-Findeisen , Haisen Ta , Axel Munk

Instance segmentation is one of the fundamental vision tasks. Recently, fully convolutional instance segmentation methods have drawn much attention as they are often simpler and more efficient than two-stage approaches like Mask R-CNN. To…

Computer Vision and Pattern Recognition · Computer Science 2020-04-28 Hao Chen , Kunyang Sun , Zhi Tian , Chunhua Shen , Yongming Huang , Youliang Yan