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We study self-regulating processes modeling biological transportation networks. Firstly, we write the formal $L^2$-gradient flow for the symmetric tensor valued diffusivity $D$ of a broad class of entropy dissipations associated with a…

Analysis of PDEs · Mathematics 2024-03-14 Jan Haskovec , Peter Markowich , Simone Portaro

We study self-regulating processes modeling biological transportation networks as presented in \cite{portaro2023}. In particular, we focus on the 1D setting for Dirichlet and Neumann boundary conditions. We prove an existence and uniqueness…

Analysis of PDEs · Mathematics 2023-08-17 Clarissa Astuto , Jan Haskovec , Peter Markowich , Simone Portaro

Biological transport networks are highly optimized structures that ensure power-efficient distribution of fluids across various domains, including animal vasculature and plant venation. Theoretically, these networks can be described as…

Biological Physics · Physics 2025-08-01 Albert Alonso , Lars Erik J. Skjegstad , Julius B. Kirkegaard

We present new analytical and numerical results for the elliptic-parabolic system of partial differential equations proposed by Hu and Cai, which models the formation of biological transport networks. The model describes the pressure field…

Analysis of PDEs · Mathematics 2015-10-14 Jan Haskovec , Peter Markowich , Benoit Perthame , Matthias Schlottbom

We develop robust and scalable fully implicit nonlinear finite element solvers for the simulations of biological transportation networks driven by the gradient flow minimization of a non-convex energy cost functional. Our approach employs a…

Computational Engineering, Finance, and Science · Computer Science 2025-04-08 Jan Haskovec , Peter Markowich , Simone Portaro , Stefano Zampini

In this paper we present a network model to study the impact of spatial distribution of constituents, coupling between them and diffusive processes in the context of biological situations. The model is in terms of network of mobile elements…

Molecular Networks · Quantitative Biology 2007-05-23 Kanchan Thadani , Ashutosh

We study an elliptic-parabolic system of partial differential equations describing formation of biological network structures. The model takes into consideration the evolution of the permeability tensor under the influence of a diffusion…

Analysis of PDEs · Mathematics 2021-11-09 Jan Haskovec , Peter Markowich , Giulia Pilli

We prove the well-posedness of entropy solutions for a wide class of nonlocal transport equations with nonlinear mobility in one spatial dimension. The solution is obtained as the limit of approximations constructed via a deterministic…

Analysis of PDEs · Mathematics 2025-09-25 Simone Fagioli , Oliver Tse

Self-regulation of living tissue as an example of self-organization phenomena in active fractal systems of biological, ecological, and social nature is under consideration. The characteristic feature of these systems is the absence of any…

Tissues and Organs · Quantitative Biology 2008-12-02 Wassily Lubashevsky , Ihor Lubashevsky , Reinhard Mahnke

Adaptive transport networks in biological and physical systems exhibit hierarchical organization, characteristic channel spacing, and robust scaling relations. Existing adaptive network models, formulated on a lattice, successfully…

Adaptation and Self-Organizing Systems · Physics 2026-05-18 Sidney Holden , Mia C. Morrell , Geoffrey Vasil , Eleni Katifori

Biological transport networks adapt through dynamic interactions between material transport and structural modification during growth and development. In this work, we present a model of transport network growth driven by local material…

Biological Physics · Physics 2025-03-27 Chanoknun Sintavanuruk , Yoichiro Mori , Reza Farhadifar , Eleni Katifori

A finite element discretization is developed for the Cai-Hu model, describing the formation of biological networks. The model consists of a non linear elliptic equation for the pressure $p$ and a non linear reaction-diffusion equation for…

Numerical Analysis · Mathematics 2025-03-28 Clarissa Astuto , Daniele Boffi , Fabio Credali

Highly-optimized complex transport networks serve crucial functions in many man-made and natural systems such as power grids and plant or animal vasculature. Often, the relevant optimization functional is non-convex and characterized by…

Biological Physics · Physics 2016-09-23 Henrik Ronellenfitsch , Eleni Katifori

Superdiffusion is an anomalous transport behavior. Recently, a new mechanism, termed the ``nodal mechanism," has been proposed to induce superdiffusion in quantum models. However, existing realizations of the nodal mechanism have so far…

Mesoscale and Nanoscale Physics · Physics 2025-11-14 Shaofeng Huang , Yu-Peng Wang , Jie Ren , Chen Fang

Motivated by recent physics papers describing rules for natural network formation, we study an elliptic-parabolic system of partial differential equations proposed by Hu and Cai. The model describes the pressure field thanks to Darcy's type…

Analysis of PDEs · Mathematics 2014-05-09 Jan Haskovec , Peter Markowich , Benoit Perthame

We propose a mesoscopic modeling framework for optimal transportation networks with biological applications. The network is described in terms of a joint probability measure on the phase space of tensor-valued conductivity and position in…

Analysis of PDEs · Mathematics 2024-01-23 Jan Haskovec , Peter Markowich , Simone Portaro

We introduce a mesoscopic model for natural network formation processes, acting as a bridge between the discrete and continuous network approach proposed by Hu and Cai. The models are based on a common approach where the dynamics of the…

Analysis of PDEs · Mathematics 2018-06-07 Martin Burger , Jan Haskovec , Peter Markowich , Helene Ranetbauer

We study general linear transport-reaction systems on an arbitrary dimensional hypercube with periodic boundary conditions. Transport-reaction systems are often used to model the finite speed movement and interaction of particles, bacteria…

Analysis of PDEs · Mathematics 2022-10-04 Benedikt Geiger

Describing particle transport at the macroscopic or mesoscopic level in non-ideal environments poses fundamental theoretical challenges in domains ranging from inter and intra-cellular transport in biology to diffusion in porous media. Yet,…

Statistical Mechanics · Physics 2013-09-11 Marta Galanti , Duccio Fanelli , Francesco Piazza

We present a stochastic optimal control problem for a tree network. The dynamics of the network are governed by transport equations with a special emphasis on the non-linear damping function. Demand profiles at the network sinks are…

Optimization and Control · Mathematics 2022-02-11 Simone Göttlich , Thomas Schillinger
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