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The inherent safety alignment of Large Language Models (LLMs) is prone to erosion during fine-tuning, even when using seemingly innocuous datasets. While existing defenses attempt to mitigate this via data selection, they typically rely on…

Machine Learning · Computer Science 2026-01-13 Haozhong Wang , Zhuo Li , Yibo Yang , He Zhao , Hongyuan Zha , Dandan Guo

LiDAR-based SLAM is recognized as one effective method to offer localization guidance in rough environments. However, off-the-shelf LiDAR-based SLAM methods suffer from significant pose estimation drifts, particularly components relevant to…

Robotics · Computer Science 2025-01-07 Yinchuan Wang , Bin Ren , Xiang Zhang , Pengyu Wang , Chaoqun Wang , Rui Song , Yibin Li , Max Q. -H. Meng

Recent work has shown impressive localization performance using only images of ground textures taken with a downward facing monocular camera. This provides a reliable navigation method that is robust to feature sparse environments and…

Robotics · Computer Science 2023-03-13 Kyle M. Hart , Brendan Englot , Ryan P. O'Shea , John D. Kelly , David Martinez

This paper demonstrates that spatial information can be used to learn interpretable representations in medical images using Self-Supervised Learning (SSL). Our proposed method, ISImed, is based on the observation that medical images exhibit…

Computer Vision and Pattern Recognition · Computer Science 2024-10-23 Nabil Jabareen , Dongsheng Yuan , Sören Lukassen

Purpose: While spiral sampling offers SNR advantages for diffusion MRI, its acceleration with simultaneous multislice remains relatively unexplored. This study introduces Laterally Oscillating Trajectory for Undersampling Slices (LOTUS),…

Medical Physics · Physics 2026-02-06 Mayuri Sothynathan , Paul I. Dubovan , Corey. A. Baron

The newly developed deep-sequencing technologies make it possible to acquire both quantitative and qualitative information regarding transcript biology. By measuring messenger RNA levels for all genes in a sample, RNA-seq provides an…

Genomics · Quantitative Biology 2014-12-05 Lerong Li , Momiao Xiong

The rapid development of digital pathology and modern deep learning has facilitated the emergence of pathology foundation models that are expected to solve general pathology problems under various disease conditions in one unified model,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-10 Yutong Sun , Sichen Zhu , Peng Qiu

Optimal transport provides a robust framework for comparing probability distributions. Its effectiveness is significantly influenced by the choice of the underlying ground metric. Traditionally, the ground metric has either been (i)…

Machine Learning · Computer Science 2025-06-19 Damin Kühn , Michael T. Schaub

Single-snapshot direction-of-arrival (DOA) estimation using sparse linear arrays (SLAs) has gained significant attention in the field of automotive MIMO radars. This is due to the dynamic nature of automotive settings, where multiple…

Signal Processing · Electrical Eng. & Systems 2023-09-18 Yunqiao Hu , Shunqiao Sun

Logistic regression remains one of the most widely used tools in applied statistics, machine learning and data science. However, in moderately high-dimensional problems, where the number of features $d$ is a non-negligible fraction of the…

Machine Learning · Statistics 2021-05-26 Steve Yadlowsky , Taedong Yun , Cory McLean , Alexander D'Amour

Image-based sequencing of mRNA makes it possible to see where in a tissue sample a given gene is active, and thus discern large numbers of different cell types in parallel. This is crucial for gaining a better understanding of tissue…

Quantitative Methods · Quantitative Biology 2018-02-27 Gabriele Partel , Giorgia Milli , Carolina Wählby

Spatial transcriptomics (ST) technologies have revolutionized the study of gene expression patterns in tissues by providing multimodality data in transcriptomic, spatial, and morphological, offering opportunities for understanding tissue…

Computational Engineering, Finance, and Science · Computer Science 2024-01-17 Zelin Zang , Liangyu Li , Yongjie Xu , Chenrui Duan , Kai Wang , Yang You , Yi Sun , Stan Z. Li

Advances in spatial transcriptomics (ST) technologies enable systematic molecular characterization of tumor microenvironment, tumor gradients and gene regulatory networks. Cancer progression is known to vary along pathological gradients,…

Developmental transcriptional networks in plants and animals operate in both space and time. To understand these transcriptional networks it is essential to obtain whole-genome expression data at high spatiotemporal resolution. Substantial…

Genomics · Quantitative Biology 2009-03-25 Dustin A. Cartwright , Siobhan M. Brady , David A. Orlando , Bernd Sturmfels , Philip N. Benfey

Advances in high-throughput sequencing technology have led to significant progress in measuring gene expressions at the single-cell level. The amount of publicly available single-cell RNA-seq (scRNA-seq) data is already surpassing 50M…

Machine Learning · Computer Science 2024-02-27 Jing Gong , Minsheng Hao , Xingyi Cheng , Xin Zeng , Chiming Liu , Jianzhu Ma , Xuegong Zhang , Taifeng Wang , Le Song

Understanding cellular trajectories via time-resolved single-cell transcriptomics is vital for studying development, regeneration, and disease. A key challenge is inferring continuous trajectories from discrete snapshots. Biological…

Optimal Transport, a theory for optimal allocation of resources, is widely used in various fields such as astrophysics, machine learning, and imaging science. However, many applications impose elementwise constraints on the transport plan…

Optimization and Control · Mathematics 2022-06-28 Zixuan Cang , Qing Nie , Yanxiang Zhao

Sequential matching using hand-crafted heuristics has been standard practice in route-based place recognition for enhancing pairwise similarity results for nearly a decade. However, precision-recall performance of these algorithms…

Computer Vision and Pattern Recognition · Computer Science 2021-03-04 Marvin Chancán , Michael Milford

Shuffled linear regression (SLR) seeks to estimate latent features through a linear transformation, complicated by unknown permutations in the measurement dimensions. This problem extends traditional least-squares (LS) and Least Absolute…

Statistics Theory · Mathematics 2025-04-17 Hang Liu , Anna Scaglione

Entropy-based inference methods have gained traction for improving the reliability of Large Language Models (LLMs). However, many existing approaches, such as entropy minimization techniques, suffer from high computational overhead and fail…

Machine Learning · Computer Science 2026-01-27 Jin Li , Zhebo Wang , Tianliang Lu , Mohan Li , Wenpeng Xing , Meng Han