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Related papers: Aligning XAI with EU Regulations for Smart Biomedi…

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Explainable AI (XAI) has evolved in response to expectations and regulations, such as the EU AI Act, which introduces regulatory requirements on AI-powered systems. However, a persistent gap remains between existing XAI methods and…

Computers and Society · Computer Science 2026-04-21 Francesco Sovrano , Giulia Vilone , Michael Lognoul

The lack of explainability of Artificial Intelligence (AI) is one of the first obstacles that the industry and regulators must overcome to mitigate the risks associated with the technology. The need for eXplainable AI (XAI) is evident in…

Computers and Society · Computer Science 2025-02-24 Georgios Pavlidis

The growing adoption of artificial intelligence in healthcare has raised concerns about the transparency and trustworthiness of AI-driven medical diagnosis systems. Many existing models operate as black boxes, limiting clinicians' ability…

Human-Computer Interaction · Computer Science 2026-04-21 Altynbek Seitenov , Ainur Nurzhanova , Azhar Bekbussinova , Yerassyl Bolatkan

Artificial Intelligence in Medicine has made significant progress with emerging applications in medical imaging, patient care, and other areas. While these applications have proven successful in retrospective studies, very few of them were…

Artificial Intelligence · Computer Science 2023-08-11 Nicoletta Prentzas , Antonis Kakas , Constantinos S. Pattichis

Last years have been characterized by an upsurge of opaque automatic decision support systems, such as Deep Neural Networks (DNNs). Although they have great generalization and prediction skills, their functioning does not allow obtaining…

The integration of artificial intelligence (AI) into medicine is remarkable, offering advanced diagnostic and therapeutic possibilities. However, the inherent opacity of complex AI models presents significant challenges to their clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Binbin Wen , Yihang Wu , Tareef Daqqaq , Ahmad Chaddad

Artificial intelligence (AI), particularly machine learning and deep learning models, has significantly impacted bioinformatics research by offering powerful tools for analyzing complex biological data. However, the lack of interpretability…

Artificial Intelligence · Computer Science 2023-12-12 Zhongliang Zhou , Mengxuan Hu , Mariah Salcedo , Nathan Gravel , Wayland Yeung , Aarya Venkat , Dongliang Guo , Jielu Zhang , Natarajan Kannan , Sheng Li

Artificial intelligence models encounter significant challenges due to their black-box nature, particularly in safety-critical domains such as healthcare, finance, and autonomous vehicles. Explainable Artificial Intelligence (XAI) addresses…

Artificial Intelligence · Computer Science 2025-03-14 Melkamu Mersha , Khang Lam , Joseph Wood , Ali AlShami , Jugal Kalita

XAI refers to the techniques and methods for building AI applications which assist end users to interpret output and predictions of AI models. Black box AI applications in high-stakes decision-making situations, such as medical domain have…

This paper investigates the relationship between law and eXplainable Artificial Intelligence (XAI). While there is much discussion about the AI Act, for which the trilogue of the European Parliament, Council and Commission recently…

Artificial Intelligence · Computer Science 2024-11-27 Benjamin Fresz , Elena Dubovitskaya , Danilo Brajovic , Marco Huber , Christian Horz

As the manufacturing industry advances with sensor integration and automation, the opaque nature of deep learning models in machine learning poses a significant challenge for fault detection and diagnosis. And despite the related predictive…

Artificial Intelligence · Computer Science 2024-06-11 Ahmed Maged , Salah Haridy , Herman Shen

Explainable artificial intelligence (XAI) is essential for enabling clinical users to get informed decision support from AI and comply with evidence-based medical practice. Applying XAI in clinical settings requires proper evaluation…

Machine Learning · Computer Science 2022-12-09 Weina Jin , Xiaoxiao Li , Mostafa Fatehi , Ghassan Hamarneh

Explainable Artificial Intelligence (XAI) is an emerging research topic of machine learning aimed at unboxing how AI systems' black-box choices are made. This research field inspects the measures and models involved in decision-making and…

Artificial Intelligence · Computer Science 2021-02-04 Guang Yang , Qinghao Ye , Jun Xia

Explainable artificial intelligence (XAI) plays an indispensable role in demystifying the decision-making processes of AI, especially within the healthcare industry. Clinicians rely heavily on detailed reasoning when making a diagnosis,…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Anna Stubbin , Thompson Chyrikov , Jim Zhao , Christina Chajo

Artificial intelligence (AI) systems utilizing deep neural networks (DNNs) and machine learning (ML) algorithms are widely used for solving important problems in bioinformatics, biomedical informatics, and precision medicine. However,…

Quantitative Methods · Quantitative Biology 2023-02-24 Md. Rezaul Karim , Tanhim Islam , Oya Beyan , Christoph Lange , Michael Cochez , Dietrich Rebholz-Schuhmann , Stefan Decker

The adoption of intelligent systems creates opportunities as well as challenges for medical work. On the positive side, intelligent systems have the potential to compute complex data from patients and generate automated diagnosis…

Human-Computer Interaction · Computer Science 2019-02-19 Yao Xie , Ge Gao , Xiang 'Anthony' Chen

The EU AI Act makes explainability urgent for high-risk AI systems, yet most XAI research focuses on technical metrics rather than regulatory compliance. Understanding how legal requirements reshape XAI method design is challenging: the AI…

Computers and Society · Computer Science 2026-03-17 Anton Hummel , Håkan Burden , Susanne Stenberg , Jan-Philipp Steghöfer , Niklas Kühl

Explainable Artificial Intelligence (XAI) is a rising field in AI. It aims to produce a demonstrative factor of trust, which for human subjects is achieved through communicative means, which Machine Learning (ML) algorithms cannot solely…

Machine Learning · Computer Science 2021-03-09 Jamie Andrew Duell

Smart home systems are gaining popularity as homeowners strive to enhance their living and working environments while minimizing energy consumption. However, the adoption of artificial intelligence (AI)-enabled decision-making models in…

Human-Computer Interaction · Computer Science 2024-07-30 Md Shajalal , Alexander Boden , Gunnar Stevens , Delong Du , Dean-Robin Kern

While artificial intelligence (AI) has made many successful applications in various domains, its adoption in healthcare lags a little bit behind other high-stakes settings. Several factors contribute to this slower uptake, including…

Artificial Intelligence · Computer Science 2023-08-10 Soheyla Amirian , Luke A. Carlson , Matthew F. Gong , Ines Lohse , Kurt R. Weiss , Johannes F. Plate , Ahmad P. Tafti
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