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Topological deep learning has emerged as a powerful paradigm for modeling higher-order relational structures beyond pairwise interactions that standard graph neural networks fail to capture. While combinatorial complexes (CCs) offer a…

Machine Learning · Computer Science 2026-03-16 Jiawen Chen , Qi Shao , Mingtong Zhou , Duxin Chen , Wenwu Yu

The visual examination of tissue biopsy sections is fundamental for cancer diagnosis, with pathologists analyzing sections at multiple magnifications to discern tumor cells and their subtypes. However, existing attention-based multiple…

Computer Vision and Pattern Recognition · Computer Science 2024-10-11 Olga Fourkioti , Matt De Vries , Chen Jin , Daniel C. Alexander , Chris Bakal

Acquiring high-quality annotated data for medical image segmentation is tedious and costly. Semi-supervised segmentation techniques alleviate this burden by leveraging unlabeled data to generate pseudo labels. Recently, advanced state space…

Computer Vision and Pattern Recognition · Computer Science 2025-08-20 Shumeng Li , Jian Zhang , Lei Qi , Luping Zhou , Yinghuan Shi , Yang Gao

Cancer diagnosis has greatly benefited from the integration of whole-slide images (WSIs) with multiple instance learning (MIL), enabling high-resolution analysis of tissue morphology. Graph-based MIL (GNN-MIL) approaches have emerged as…

Computer Vision and Pattern Recognition · Computer Science 2025-08-27 Jongwoo Kim , Bryan Wong , Huazhu Fu , Willmer Rafell Quiñones , Youngsin Ko , Mun Yong Yi

Multiple Instance Learning (MIL) has become the predominant approach for classification tasks on gigapixel histopathology whole slide images (WSIs). Within the MIL framework, single WSIs (bags) are decomposed into patches (instances), with…

Computer Vision and Pattern Recognition · Computer Science 2023-03-03 Daniel Sens , Ario Sadafi , Francesco Paolo Casale , Nassir Navab , Carsten Marr

We address the challenging problem of whole slide image (WSI) classification. WSIs have very high resolutions and usually lack localized annotations. WSI classification can be cast as a multiple instance learning (MIL) problem when only…

Computer Vision and Pattern Recognition · Computer Science 2021-04-05 Bin Li , Yin Li , Kevin W. Eliceiri

Point cloud segmentation is an important topic in 3D understanding that has traditionally has been tackled using either the CNN or Transformer. Recently, Mamba has emerged as a promising alternative, offering efficient long-range contextual…

Computer Vision and Pattern Recognition · Computer Science 2024-10-29 Yong Xien Chng , Xuchong Qiu , Yizeng Han , Yifan Pu , Jiewei Cao , Gao Huang

This paper attacks an emerging challenge of multi-modal retinal disease recognition. Given a multi-modal case consisting of a color fundus photo (CFP) and an array of OCT B-scan images acquired during an eye examination, we aim to build a…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 Xirong Li , Yang Zhou , Jie Wang , Hailan Lin , Jianchun Zhao , Dayong Ding , Weihong Yu , Youxin Chen

Medical image segmentation plays an important role in various clinical applications; however, existing deep learning models face trade-offs between efficiency and accuracy. Convolutional Neural Networks (CNNs) capture local details well but…

Image and Video Processing · Electrical Eng. & Systems 2025-10-20 Saqib Qamar , Mohd Fazil , Parvez Ahmad , Shakir Khan , Abu Taha Zamani

Histopathology image analysis is the golden standard of clinical diagnosis for Cancers. In doctors daily routine and computer-aided diagnosis, the Whole Slide Image (WSI) of histopathology tissue is used for analysis. Because of the…

Computer Vision and Pattern Recognition · Computer Science 2023-11-23 Honglin Li , Yunlong Zhang , Chenglu Zhu , Jiatong Cai , Sunyi Zheng , Lin Yang

Accurate medical image segmentation demands the integration of multi-scale information, spanning from local features to global dependencies. However, it is challenging for existing methods to model long-range global information, where…

Image and Video Processing · Electrical Eng. & Systems 2024-03-07 Jiarun Liu , Hao Yang , Hong-Yu Zhou , Yan Xi , Lequan Yu , Yizhou Yu , Yong Liang , Guangming Shi , Shaoting Zhang , Hairong Zheng , Shanshan Wang

Multi-Instance Learning (MIL) is pivotal for analyzing complex, weakly labeled datasets, such as whole-slide images (WSIs) in computational pathology, where bags comprise unordered collections of instances with sparse diagnostic relevance.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Yuedi Zhang , Zhixiang Xia , Guosheng Yin , Bin Liu

This paper introduces Bio-Inspired Mamba (BIM), a novel online learning framework for selective state space models that integrates biological learning principles with the Mamba architecture. BIM combines Real-Time Recurrent Learning (RTRL)…

Neural and Evolutionary Computing · Computer Science 2024-09-18 Jiahao Qin

Medical image segmentation plays an important role in computer-aided diagnosis. Traditional convolution-based U-shape segmentation architectures are usually limited by the local receptive field. Existing vision transformers have been widely…

Computer Vision and Pattern Recognition · Computer Science 2025-07-29 Qing Xu , Yanming Chen , Yue Li , Ziyu Liu , Zhenye Lou , Yixuan Zhang , Xiangjian He

As one of the most effective methods for cardiovascular disease (CVD) diagnosis, multi-lead Electrocardiogram (ECG) signals present a characteristic multi-sensor information fusion challenge that has been continuously researched in deep…

Signal Processing · Electrical Eng. & Systems 2025-09-04 Huaicheng Zhang , Ruoxin Wang , Chenlian Zhou , Jiguang Shi , Yue Ge , Zhoutong Li , Sheng Chang , Hao Wang , Jin He , Qijun Huang

State-space models (SSMs), particularly Mamba, emerge as an efficient Transformer alternative with linear complexity for long-sequence modeling. Recent empirical works demonstrate Mamba's in-context learning (ICL) capabilities competitive…

Machine Learning · Computer Science 2025-09-30 Jiarui Jiang , Wei Huang , Miao Zhang , Taiji Suzuki , Liqiang Nie

Multi-Instance Learning(MIL) aims to learn the mapping between a bag of instances and the bag-level label. Therefore, the relationships among instances are very important for learning the mapping. In this paper, we propose an MIL algorithm…

Machine Learning · Computer Science 2021-02-04 Yangling Ma , Zhouwang Yang

Accurate prediction of RNA-associated interactions is essential for understanding cellular regulation and advancing drug discovery. While Biological Large Language Models (BioLLMs) such as ESM-2 and RiNALMo provide powerful sequence…

Genomics · Quantitative Biology 2026-02-27 Rabeya Tus Sadia , Qiang Ye , Qiang Cheng

The advent of single-cell multi-omics technologies has enabled the simultaneous profiling of diverse omics layers within individual cells. Integrating such multimodal data provides unprecedented insights into cellular identity, regulatory…

Cell Behavior · Quantitative Biology 2025-06-27 Zhen Yuan , Shaoqing Jiao , Yihang Xiao , Jiajie Peng

The whole slide image (WSI) classification is often formulated as a multiple instance learning (MIL) problem. Since the positive tissue is only a small fraction of the gigapixel WSI, existing MIL methods intuitively focus on identifying…

Computer Vision and Pattern Recognition · Computer Science 2023-12-22 Wenhao Tang , Sheng Huang , Xiaoxian Zhang , Fengtao Zhou , Yi Zhang , Bo Liu