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Disease progression modeling (DPM) using longitudinal data is a challenging machine learning task. Existing DPM algorithms neglect temporal dependencies among measurements, make parametric assumptions about biomarker trajectories, do not…

Computer Vision and Pattern Recognition · Computer Science 2019-03-19 Mostafa Mehdipour Ghazi , Mads Nielsen , Akshay Pai , M. Jorge Cardoso , Marc Modat , Sebastien Ourselin , Lauge Sørensen

The Monte Carlo dropout method has proved to be a scalable and easy-to-use approach for estimating the uncertainty of deep neural network predictions. This approach was recently applied to Fault Detection and Di-agnosis (FDD) applications…

Machine Learning · Computer Science 2019-09-11 Baihong Jin , Yingshui Tan , Yuxin Chen , Alberto Sangiovanni-Vincentelli

Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative disorders in humans. Because a significant percentage of patients have clinical and pathological features of both diseases, it has been…

Quantitative Methods · Quantitative Biology 2019-06-10 Dhruv Agarwal , Abhishek Srivastava , Edward W Huang

Studies of Alzheimer's disease (AD) often collect multiple longitudinal clinical outcomes, which are correlated and predictive of AD progression. It is of great scientific interest to investigate the association between the outcomes and…

Methodology · Statistics 2021-05-18 Cai Li , Luo Xiao , Sheng Luo

Alzheimers disease is a fatal progressive brain disorder that worsens with time. It is high time we have inexpensive and quick clinical diagnostic techniques for early detection and care. In previous studies, various Machine Learning…

Computation and Language · Computer Science 2021-09-27 Akshay Valsaraj , Ithihas Madala , Nikhil Garg , Veeky Baths

For decades, a variety of predictive approaches have been proposed and evaluated in terms of their prediction capability for Alzheimer's Disease (AD) and its precursor - mild cognitive impairment (MCI). Most of them focused on prediction or…

Neurons and Cognition · Quantitative Biology 2022-12-20 Lu Zhang , Li Wang , Tianming Liu , Dajiang Zhu

Machine Learning (ML) algorithms are vital for supporting clinical decision-making in biomedical informatics. However, their predictive performance can vary across demographic groups, often due to the underrepresentation of historically…

Machine Learning · Computer Science 2025-03-04 Ioannis Bilionis , Ricardo C. Berrios , Luis Fernandez-Luque , Carlos Castillo

Humans possess a finely tuned sense of uncertainty that helps anticipate potential errors, vital for adaptive behavior and survival. However, the underlying neural mechanisms remain unclear. This study applies moment neural networks (MNNs)…

Biological Physics · Physics 2024-11-22 Hengyuan Ma , Wenlian Lu , Jianfeng Feng

Alongside neuroimaging such as MRI scans and PET, Alzheimer's disease (AD) datasets contain valuable tabular data including AD biomarkers and clinical assessments. Existing computer vision approaches struggle to utilize this additional…

Computer Vision and Pattern Recognition · Computer Science 2023-08-30 Weichen Huang

Building on the success of the ADReSS Challenge at Interspeech 2020, which attracted the participation of 34 teams from across the world, the ADReSSo Challenge targets three difficult automatic prediction problems of societal and medical…

Audio and Speech Processing · Electrical Eng. & Systems 2021-04-20 Saturnino Luz , Fasih Haider , Sofia de la Fuente , Davida Fromm , Brian MacWhinney

Alzheimer's Dementia (AD) is a progressive neurodegenerative disease marked by irreversible decline, making reliable modeling of its progression essential for effective patient care. Progression-aware methods such as survival analysis are…

Alzheimer's Disease (AD) is a progressive neurodegenerative disease. Amnestic mild cognitive impairment (MCI) is a common first symptom before the conversion to clinical impairment where the individual becomes unable to perform activities…

Computer Vision and Pattern Recognition · Computer Science 2017-10-16 Donghuan Lu , Karteek Popuri , Weiguang Ding , Rakesh Balachandar , Mirza Faisal Beg

One of the most catastrophic neurological disorders worldwide is Parkinson's Disease. Along with it, the treatment is complicated and abundantly expensive. The only effective action to control the progression is diagnosing it in the early…

Machine Learning · Computer Science 2023-10-23 Md. Taufiqul Haque Khan Tusar , Md. Touhidul Islam , Abul Hasnat Sakil

Alzheimer's detection efforts aim to develop accurate models for early disease diagnosis. Significant advances have been achieved with convolutional neural networks and vision transformer based approaches. However, medical datasets suffer…

Computer Vision and Pattern Recognition · Computer Science 2025-05-29 Zobia Batool , Huseyin Ozkan , Erchan Aptoula

Supporting model interpretability for complex phenomena where annotators can legitimately disagree, such as emotion recognition, is a challenging machine learning task. In this work, we show that explicitly quantifying the uncertainty in…

Machine Learning · Computer Science 2019-10-08 Asma Ghandeharioun , Brian Eoff , Brendan Jou , Rosalind W. Picard

Accurate brain tumor segmentation from MRI is vital for diagnosis and treatment planning. Although Monte Carlo (MC) Dropout is widely used to estimate model uncertainty, the effectiveness of variance-based uncertainty - computed as…

Machine Learning · Computer Science 2026-05-28 Saumya B

Alzheimer's disease is a debilitating disorder marked by a decline in cognitive function. Timely identification of the disease is essential for the development of personalized treatment strategies that aim to mitigate its progression. The…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Xin Hong , Kaifeng Huang

We propose MC-CIM, a compute-in-memory (CIM) framework for robust, yet low power, Bayesian edge intelligence. Deep neural networks (DNN) with deterministic weights cannot express their prediction uncertainties, thereby pose critical risks…

Machine Learning · Computer Science 2021-11-16 Priyesh Shukla , Shamma Nasrin , Nastaran Darabi , Wilfred Gomes , Amit Ranjan Trivedi

This paper presents the EACare project, an ambitious multi-disciplinary collaboration with the aim to develop an embodied system, capable of carrying out neuropsychological tests to detect early signs of dementia, e.g., due to Alzheimer's…

Pattern recognition methods using neuroimaging data for the diagnosis of Alzheimer's disease have been the subject of extensive research in recent years. In this paper, we use deep learning methods, and in particular sparse autoencoders and…

Computer Vision and Pattern Recognition · Computer Science 2015-02-10 Adrien Payan , Giovanni Montana
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