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Scientific applications that involve simulation ensembles can be accelerated greatly by using experiment design methods to select the best simulations to perform. Methods that use machine learning (ML) to create proxy models of simulations…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-03-16 Logan Ward , Ganesh Sivaraman , J. Gregory Pauloski , Yadu Babuji , Ryan Chard , Naveen Dandu , Paul C. Redfern , Rajeev S. Assary , Kyle Chard , Larry A. Curtiss , Rajeev Thakur , Ian Foster

As AI agents take on increasingly long-running tasks involving sophisticated planning and execution, there is a corresponding need for novel interaction designs that enable deeper human-agent collaboration. However, most prior works…

Human-Computer Interaction · Computer Science 2026-02-19 K. J. Kevin Feng , Kevin Pu , Matt Latzke , Tal August , Pao Siangliulue , Jonathan Bragg , Daniel S. Weld , Amy X. Zhang , Joseph Chee Chang

Exascale computing holds great opportunities for molecular dynamics (MD) simulations. However, to take full advantage of the new possibilities, we must learn how to focus computational power on the discovery of complex molecular mechanisms,…

Chemical Physics · Physics 2019-01-16 Hendrik Jung , Roberto Covino , Gerhard Hummer

Over the last two decades, the field of computational science has seen a dramatic shift towards incorporating high-throughput computation and big-data analysis as fundamental pillars of the scientific discovery process. This has…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-11-18 Martin Uhrin , Sebastiaan P. Huber , Jusong Yu , Nicola Marzari , Giovanni Pizzi

Modern scientific discovery increasingly requires coordinating distributed facilities and heterogeneous resources, forcing researchers to act as manual workflow coordinators rather than scientists. Advances in AI leading to AI agents show…

Artificial Intelligence · Computer Science 2025-09-15 Woong Shin , Renan Souza , Daniel Rosendo , Frédéric Suter , Feiyi Wang , Prasanna Balaprakash , Rafael Ferreira da Silva

LLMs' remarkable ability to tackle a wide range of language tasks opened new opportunities for collaborative human-AI problem solving. LLMs can amplify human capabilities by applying their intuitions and reasoning strategies at scale. We…

Computation and Language · Computer Science 2025-09-23 Abhishek Sharma , Dan Goldwasser

Artificial intelligence is transforming molecular and materials science, but its growing computational and data demands raise critical sustainability challenges. In this Perspective, we examine resource considerations across the AI-driven…

Increasingly, scientific discovery requires sophisticated and scalable workflows. Workflows have become the ``new applications,'' wherein multi-scale computing campaigns comprise multiple and heterogeneous executable tasks. In particular,…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-08-26 Shantenu Jha , Vincent R. Pascuzzi , Matteo Turilli

Exascale computers will offer transformative capabilities to combine data-driven and learning-based approaches with traditional simulation applications to accelerate scientific discovery and insight. These software combinations and…

Over the past decade, machine learning model complexity has grown at an extraordinary rate, as has the scale of the systems training such large models. However there is an alarmingly low hardware utilization (5-20%) in large scale AI…

Hardware Architecture · Computer Science 2022-11-14 Newsha Ardalani , Saptadeep Pal , Puneet Gupta

Agentic systems, in which diverse agents cooperate to tackle challenging problems, are exploding in popularity in the AI community. However, existing agentic frameworks take a relatively narrow view of agents, apply a centralized model, and…

Multiagent Systems · Computer Science 2026-01-30 Alok Kamatar , J. Gregory Pauloski , Yadu Babuji , Ryan Chard , Mansi Sakarvadia , Daniel Babnigg , Kyle Chard , Ian Foster

Recent improvements in large language models have opened new opportunities for accelerating and automating scientific workflows. In parallel, modern collider analyses are becoming increasingly complex and demand substantial programming and…

High Energy Physics - Phenomenology · Physics 2026-02-09 W. Esmail , A. Hammad , M. Nojiri

Progress in science is deeply bound to the effective use of high-performance computing infrastructures and to the efficient extraction of knowledge from vast amounts of data. Such data comes from different sources that follow a cycle…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-06-15 Rosa M Badia , Jorge Ejarque , Francesc Lordan , Daniele Lezzi , Javier Conejero , Javier Álvarez Cid-Fuentes , Yolanda Becerra , Anna Queralt

A computational workflow, also known as workflow, consists of tasks that are executed in a certain order to attain a specific computational campaign. Computational workflows are commonly employed in science domains, such as physics,…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-05-13 Krishnan Raghavan , George Papadimitriou , Hongwei Jin , Anirban Mandal , Mariam Kiran , Prasanna Balaprakash , Ewa Deelman

As Large Language Models increasingly automate complex, long-horizon tasks such as \emph{vibe coding}, a supervision gap has emerged. While models excel at execution, users often struggle to guide them effectively due to insufficient domain…

Artificial Intelligence · Computer Science 2026-02-09 Enyu Zhou , Zhiheng Xi , Long Ma , Zhihao Zhang , Shihan Dou , Zhikai Lei , Guoteng Wang , Rui Zheng , Hang Yan , Tao Gui , Qi Zhang , Xuanjing Huang

The collaborative efforts of large communities in science experiments, often comprising thousands of global members, reflect a monumental commitment to exploration and discovery. Recently, advanced and complex data processing has gained…

AI agents are emerging as a practical way to run multi-step scientific workflows that interleave reasoning with tool use and verification, pointing to a shift from isolated AI-assisted steps toward \emph{agentic science at scale}. This…

Heterogeneous hardware and dynamic workloads worsen long-standing OS bottlenecks in scalability, adaptability, and manageability. At the same time, advances in machine learning (ML), large language models (LLMs), and agent-based methods…

Operating Systems · Computer Science 2025-11-12 Yifan Zhang , Xinkui Zhao , Ziying Li , Guanjie Cheng , Jianwei Yin , Lufei Zhang , Zuoning Chen

Applications that fuse machine learning and simulation can benefit from the use of multiple computing resources, with, for example, simulation codes running on highly parallel supercomputers and AI training and inference tasks on…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-12-04 Logan Ward , J. Gregory Pauloski , Valerie Hayot-Sasson , Ryan Chard , Yadu Babuji , Ganesh Sivaraman , Sutanay Choudhury , Kyle Chard , Rajeev Thakur , Ian Foster

Artificial intelligence (AI) is reshaping how research is conceived, conducted, and communicated across fields from chemistry to biomedicine. This commentary examines how AI is transforming the research workflow. AI systems now help…

Artificial Intelligence · Computer Science 2025-11-14 Maksim E. Eren , Dorianis M. Perez
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