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Bayesian spatial modeling provides a flexible framework for whole-brain fMRI analysis by explicitly incorporating spatial dependencies, overcoming the limitations of traditional massive univariate approaches that lead to information waste.…

Methodology · Statistics 2025-11-18 Yuan Zhong , Gang Chen , Paul A. Taylor , Jian Kang

By combining related objects, unsupervised machine learning techniques aim to reveal the underlying patterns in a data set. Non-negative Matrix Factorization (NMF) is a data mining technique that splits data matrices by imposing…

Artificial Intelligence · Computer Science 2023-08-10 Yasser Khalafaoui , Nistor Grozavu , Basarab Matei , Laurent-Walter Goix

We introduce a unified framework for evaluating dimensionality reduction techniques in spatial transcriptomics beyond standard PCA approaches. We benchmark six methods PCA, NMF, autoencoder, VAE, and two hybrid embeddings on a…

Motivated by problems in data clustering, we establish general conditions under which families of nonparametric mixture models are identifiable, by introducing a novel framework involving clustering overfitted \emph{parametric} (i.e.…

Statistics Theory · Mathematics 2020-02-19 Bryon Aragam , Chen Dan , Eric P. Xing , Pradeep Ravikumar

It is more and more common to explore the genome at diverse levels and not only at a single omic level. Through integrative statistical methods, omics data have the power to reveal new biological processes, potential biomarkers, and…

Methodology · Statistics 2021-03-05 Morgane Pierre-Jean , Florence Mauger , Jean-François Deleuze , Edith Le Floch

Determining the appropriate number of clusters in unsupervised learning is a central problem in statistics and data science. Traditional validity indices such as Calinski-Harabasz, Silhouette, and Davies-Bouldin-depend on centroid-based…

Machine Learning · Statistics 2025-10-17 Mohammed Baragilly , Hend Gabr

Structural regularities in man-made environments reflect in the distribution of their surface normals. Describing these surface normal distributions is important in many computer vision applications, such as scene understanding, plane…

Computer Vision and Pattern Recognition · Computer Science 2016-11-15 Julian Straub , Trevor Campbell , Jonathan P. How , John W. Fisher

Identifying genes that display spatial patterns is critical to investigating expression interactions within a spatial context and further dissecting biological understanding of complex mechanistic functionality. Despite the increase in…

Methodology · Statistics 2025-10-06 Mingcong Wu , Yang Li , Shuangge Ma , Mengyun Wu

Recently, Mamba-based methods, with its advantage in long-range information modeling and linear complexity, have shown great potential in optimizing both computational cost and performance of light field image super-resolution (LFSR).…

Computer Vision and Pattern Recognition · Computer Science 2025-09-08 Haosong Liu , Xiancheng Zhu , Huanqiang Zeng , Jianqing Zhu , Jiuwen Cao , Junhui Hou

Modern spectroscopic databases provide a wealth of information about the physical processes and environments associated with astrophysical populations. Techniques such as blind source separation (BSS), in which sets of spectra are…

Astrophysics · Physics 2009-11-13 James T. Allen , Paul C. Hewett , Vasily Belokurov , Vivienne Wild

Bayesian model-based clustering is a widely applied procedure for discovering groups of related observations in a dataset. These approaches use Bayesian mixture models, estimated with MCMC, which provide posterior samples of the model…

Methodology · Statistics 2018-09-24 Ketong Wang , Michael D. Porter

Bayesian nonparametrics are a class of probabilistic models in which the model size is inferred from data. A recently developed methodology in this field is small-variance asymptotic analysis, a mathematical technique for deriving learning…

Machine Learning · Statistics 2017-07-27 Trevor Campbell , Brian Kulis , Jonathan How

Unsupervised integrative analysis of multiple data sources has become common place and scalable algorithms are necessary to accommodate ever increasing availability of data. Only few currently methods have estimation speed as their focus,…

Methodology · Statistics 2024-05-17 Felix Held

Understanding the association between dietary patterns and health outcomes, such as the cancer risk, is crucial to inform public health guidelines and shaping future dietary interventions. However, dietary intake data present several…

Methodology · Statistics 2025-10-10 Blake Hansen , Dafne Zorzetto , Valeria Edefonti , Roberta De Vito

Identifying high-dimensional data patterns without a priori knowledge is an important task of data science. This paper proposes a simple and efficient noparametric algorithm: Data Convert to Sequence Analysis, DCSA, which dynamically…

Machine Learning · Computer Science 2022-12-05 Shi Guobin

Clustering algorithms became an essential part of the neurophysiological data analysis toolbox in the last twenty five years. Many problems, from the definition of cell types/groups based on morphological, molecular and physiological data…

Applications · Statistics 2025-09-23 Louise Martineau , Christophe Pouzat , Ségolen Geffray

Analyzing multiple studies allows leveraging data from a range of sources and populations, but until recently, there have been limited methodologies to approach the joint unsupervised analysis of multiple high-dimensional studies. A recent…

Methodology · Statistics 2020-07-27 Isabella N. Grabski , Roberta De Vito , Lorenzo Trippa , Giovanni Parmigiani

Clustering on the data with multiple aspects, such as multi-view or multi-type relational data, has become popular in recent years due to their wide applicability. The approach using manifold learning with the Non-negative Matrix…

Machine Learning · Computer Science 2020-09-08 Khanh Luong , Richi Nayak

The advent of single-cell multi-omics technologies has enabled the simultaneous profiling of diverse omics layers within individual cells. Integrating such multimodal data provides unprecedented insights into cellular identity, regulatory…

Cell Behavior · Quantitative Biology 2025-06-27 Zhen Yuan , Shaoqing Jiao , Yihang Xiao , Jiajie Peng

Spatial transcriptomics (ST) provides essential spatial context by mapping gene expression within tissue, enabling detailed study of cellular heterogeneity and tissue organization. However, aligning ST data with histology images poses…